Anti-HMGCR Specificity of HALIP: A Confirmatory Study

Baucells, Andres; Martínez, María Ángeles; Alvarado-Cárdenas, Marcelo; Mariscal, Anaís; Martínez-Martínez, Laura; Júarez, Cándido; Selva-O’Callaghan, Albert

doi:10.1155/2020/6292631

Cited by 2 publications

(1 citation statement)

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“…Immune mediated necrotizing myopathy (IMNM) is characterized by progressive and disabling proximal muscle weakness, high serum levels of creatine kinase (CK) and the presence of necrotic fibers with minimal inflammatory cell infiltrate on muscle biopsy. 1,2 The European Neuromuscular Centre has recognized three serologically different subtypes of IMNM: autoantibody negative, anti-signal recognition particle and anti-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy. Recently, several cases of anti-HMGCR myopathy associated with statins exposure were described, which raised the profile of this IMNM and the need to diagnose it as soon as possible.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies

et al. 2022

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Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. Although the diagnosis of myopathies relies on muscle biopsy, which is considered the gold-standard, the search for autoantibodies has proved to be an essential contribution to the diagnosis of immune-mediated myopathies. The detection of anti-HMGCR antibodies in the patient’s serum can be performed by enzyme immunoassays, and more recently, by imunofluorescence. As for the latter, the detection of anti-HMGCR antibodies is performed on tissue sections by indirect immunofluorescence and is characterized by a typical fluorescence pattern called “HMGCR Associated Liver IFL Pattern”. The authors present two case reports that show the importance of diagnosing statin-induced necrotizing myopathy as quickly as possible and the contribution of anti-HMGCR antibody detection for the diagnosis.

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Section: Introductionmentioning

confidence: 99%