Anti-human immunodeficiency virus phenolics from licorice.

Herbal Drugs in Traditional Japanese Medicine

“…Licochalcone A (13), isolicoflavonol (14), glycycoumarin (15), glycyrrhisoflavone (16), and licopyranocoumarin (17) inhibited at a 1:25 concentration (20 μg/ml) relative to that of glychyrrhiziin showed an analogous effect (500 μg/ml) ( Fig. 8) [30]. Further investigation revealed that the HIV promoter activity induced by 12-O-tetradecanoylphorbol-13-O-acetate is suppressed by licorice phenolics.…”

Herbal Medicine and False-Positive Results on Lymphocyte Transformation Test

“…21) Tannin-containing compounds have been reported to exert various biological activities such as antibacterial 22) and antiviral eŠects. [23][24][25] Ohtsu 26) reported that the mitogenic substance in Bupleurum chinence is a polyphenol. Tannin is attached to the polyphenol group as indicated by its structure with the``hydroxyl group''.…”

Licorice as a Resource for Pharmacologically Active Phenolic Substances: Antioxidant and Antimicrobial Effects

“…Thus, centrifugal partition chromatography (CPC) and droplet countercurrent chromatography (DCCC), which were devised as efective methods for CCD, in addition to simple CCD using separatory funnels, were applied to purify the licorice phenolics in our studies. The solvent system chloroform-methanol-water (7:13:8, by volume) was primarily used for the separation of licorice phenolics derived from Glycyrrhiza inlata [9,10] and those derived from G. uralensis [11][12][13][14][15][16] in these CCD processes. Combinations of column chromatography on a silica gel, ODS-gel, and/or polystyrene gel (MCI-gel CHP-20P) with CCD also aforded satisfactory separation [17,18].…”

“…HIV causes a "giant cell" in the infected cells OKM-3T (= OKM-1) due to the cytopathic efects of the virus. The aforementioned compounds had inhibitory efects on giant cell formation of a cell line infected with HIV [11,30]. The mechanisms underlying these antiviral efects may be diferent from those observed for tannins [31].…”