Anti-hyperglycaemic Activity of &lt;i&gt;Tribulus terrestris&lt;/i&gt; L Aerial Part Extract in Glucose-loaded Normal Rabbits

El-Shaibany, Amina; AL-Habori, Molham; Al-Tahami, Belqes Abdullah Mohammad; Massarani, Shaza Al

doi:10.4314/tjpr.v14i12.16

Cited by 28 publications

(28 citation statements)

References 16 publications

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“…The efficacy of Tribulus terrestris extract in normalizing blood glucose, both basal and postprandial, has already been reported in diabetic rabbits. An improvement in insulinemia was also observed in these studies [ 12 ]. The effect of Tribulus terrestris on glucose level may be the result of increased alpha-glucosidase and aldose-reductase activity, suggesting that the action is antihyperglycemic and not hypoglycemic.…”

Section: Discussionsupporting

confidence: 69%

Tribulus terrestris Efficacy and Safety Concerns in Diabetes and Erectile Dysfunction, Assessed in an Experimental Model

Ștefănescu

Farczádi

Huţanu

et al. 2021

Plants

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The present project aims to evaluate Tribulus terrestris (TT) extracts by addressing various possible mechanisms of action in order to see whether the use of TT supplements in diabetes and diabetes complications is justified. Diabetic rats were divided into three groups: diabetic control group, TT extract with low protodioscin content group (TT-LPC) and TT extract with high protodioscin content group (TT-HPC). After twelve weeks of treatment, fasting blood glucose, insulin, LH, FSH and testosterone levels were measured. Both TT preparations reduced elevated blood glucose level. Insulin and luteinizing hormone levels were not significantly different compared with the control group; however, the FSH and testosterone levels were significantly higher in the TT-HPC group compared with the diabetic control group. The testosterone level is correlated in part with the protodioscin concentration in extracts and is probably mediated through an FSH-linked pathway.

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Section: Discussionsupporting

confidence: 69%

Tribulus terrestris Efficacy and Safety Concerns in Diabetes and Erectile Dysfunction, Assessed in an Experimental Model

Ștefănescu

Farczádi

Huţanu

et al. 2021

Plants

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“…The methanol extracts mainly consisted of flavonoids, anthraquinones, phenols/tannins, and steroids/triterpenes. As a result, there were no toxic symptoms or mortality observed in any animals and no obvious differences between the treated and control animals regarding behavioural changes and toxicological signs (general behaviour, motor activities, aggressiveness, reaction to noise, reaction to pinch, state of the tail and state of excrement) [ 110 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

133

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Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.

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“…Many therapeutic actions have reports for the plant extracts since dry fruits extract of Tribulus terrestris showed free radical scavenging activity (Vangalapati et al, 2014). In addition, it has anti-inflammatory, immunomodulatory, diuretic, anti-urolithic, anti-diabetic, absorption enhancing, hypolipidemic, cardiotonic, hepatoprotective, analgesic, antispasmodic, antibacterial, anthelmintic, larvicidal and anticarcinogenic activities (Chhatre et al, 2014;El-Shaibany et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Tribulus terrestris Against Gentamicin Mediated Nephrotoxicity, Oxidative Damage and Apoptosis in Male Rats

Kilany

Abdou

El-Beltagy

et al. 2020

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Gentamicin (GNT) is an aminoglycoside antibiotic that is that's employed in the treatment of diverse forms of bacterial infections. However, gentamicin evoked renal toxicity. Therefore, the present experiment investigated the protecting impact of Tribulus terrestris and vitamin C against GNT-induced renal toxicity in albino rats. Six groups with eight rats each were used for this purpose; they included the normal control group that received physiological saline, the second group received Tribulus terrestris (200 mg kg orally), the third group received Vit. C (200 mg kg, orally). The fourth group injected gentamicin sulfate (100mg/kg I/P). The fifth group received Tribulus terrestris (200 mg kg orally) then injected with gentamicin sulfate, the sixth group received Vit. C (200 mg kg orally) then injected with gentamicin sulfate. The results showed that GNT significantly decreases serum levels of total protein and albumin. On the other hand, there were significant increases in levels of BUN, creatinine, and uric acid. Significant decreases were recorded in the levels of catalase (CAT) and superoxide dismutase (SOD). In addition, there was a substantial increase in the kidney contents of malondialdehyde (MDA). Serum levels of beta 2 microglobulin (β2M), nitric oxide (NO), and kidney injury molecule-1 (KIM-1) were substantially magnified but glutathione S transferase (GST) was significantly declined. Also, GNT caused histopathological changes and increased the expression of caspase-3 in the kidney tissues. However, administration of Tribulus terrestris as well as vitamin C, ameliorated the GNT-induced nephrotoxicity, perhaps via their antioxidant properties.

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Anti-hyperglycaemic Activity of <i>Tribulus terrestris</i> L Aerial Part Extract in Glucose-loaded Normal Rabbits

Cited by 28 publications

References 16 publications

Tribulus terrestris Efficacy and Safety Concerns in Diabetes and Erectile Dysfunction, Assessed in an Experimental Model

Tribulus terrestris Efficacy and Safety Concerns in Diabetes and Erectile Dysfunction, Assessed in an Experimental Model

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Protective Effects of Tribulus terrestris Against Gentamicin Mediated Nephrotoxicity, Oxidative Damage and Apoptosis in Male Rats

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