Anti-hyperglycemic effect of aqueous extract of Juglans regia L. leaf (walnut leaf) on type 2 diabetic patients: A randomized controlled trial

Abdoli, Mahsima; Dabaghian, Fataneh Hashem; Goushegir, Ashrafeddin; Shirazi, Maryam Taghavi; Nakhjavani, M; Shojaii, Asie; Rezvani, Shirin; Mahlooji, Kamran

doi:10.1016/j.aimed.2017.10.001

Cited by 12 publications

(13 citation statements)

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“…(2015) evaluated the anti-hyperuricemia potential of J. regia leaves by determining the xanthine oxidase inhibitory activity. Moreover, the extensive evidences on the anti-diabetic activity of walnut leaves encouraged Abdoli et al (2017) to carry out a human trial using walnut leaves-based preparations in Type II diabetic patients, obtaining positive results for the reduction of the glycemic index and HbA1c (glycated hemoglobin) values.…”

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confidence: 99%

Phenolic profile, antioxidant and antibacterial properties of Juglans regia L. (walnut) leaves from the Northeast of Portugal

Vieira

Pereira

Pires

et al. 2019

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Juglans regia L. (walnut tree) is a recognized source of bioactive compounds with potential health benefits. In this work, hydroethanolic extracts of J. regia leaves were obtained by heat assisted extraction from different Portuguese samples in two phenological stages (green and yellow leaves) aiming to assess the impact of seasonal variations. The samples were compared regarding their phenolic composition and bioactivity. Seventeen phenolic compounds were identified by liquid chromatography combined with a diode array detector and electrospray ionization mass spectrometer (LC-DAD-ESI/MS n ): six phenolic acids, ten flavonoids and one tetralone derivative. The green leaves extracts presented a higher amount of total phenolic compounds (29.70 ± 0.03 mg/g extract) compared with the yellow leaves (23.26 ± 0.06 mg/g extract). In particular, yellow samples were richer in flavonoids (17.4 ± 0.2 mg/g extract; mainly quercetin-3-O-glucoside: 3.64 ± 0.01 mg/g extract), while the green ones presented higher phenolic acids content (16.7 ± 0.2 mg/g extract; mainly trans 3-p-coumaroylquinic acid: 6.9 ± 0.5 mg/g extract). Green leaves extract also presented higher antioxidant potential, achieving IC 50 values around 32 ± 2 μg/mL and 26.8 ± 0.2 μg/mL for the oxidative haemolysis inhibition and the thiobarbituric acid reactive substances assays, respectively. Furthermore, only green leaves samples showed anti-inflammatory potential. The cytotoxic evaluations revealed similar antiproliferative action of both extracts against the tumor cell lines tested. Also, an analogous anti-bacterial potential of the extracts was observed, with preferential action against Gram-positive clinical isolated bacteria, with lower minimum inhibitory concentration (MIC) values for Enterococcus faecalis and Listeria monocytogenes (MIC = 2.5 mg/mL). Therefore, the present study suggests the use of walnut leaves as a source of active ingredients without hepatotoxic effects to be used in different applications in the food or pharmaceutical areas.

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confidence: 99%

Phenolic profile, antioxidant and antibacterial properties of Juglans regia L. (walnut) leaves from the Northeast of Portugal

Vieira

Pereira

Pires

et al. 2019

Industrial Crops and Products

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“…The review included 195 individuals from 4 studies. All 4 RCTs were conducted in Iran, on T2DM patients, and both genders [ 13 22 23 24 ]. Sample sizes varied from 37 to 61, the duration of intervention in the studies was 8 and 12 weeks, whilst the dosage of JRLE varied from 200 to 750 mg/day; where in one study, the intervention was defined as 100 mg/day for one week, then continued with 200 mg/day for 7 weeks [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, current evidence from trial studies investigating the effectiveness of JRLE on blood glucose and lipid parameters of T2DM patients in humans is controversial [ 13 22 23 24 ]. Rabiei et al [ 13 ] didn’t observe any significant effects of 200 mg/d JRLE on blood glucose and homeostasis model assessment of insulin resistance (HOMA-IR) levels whilst Hosseini et al [ 23 ] reported that consumption of 100 mg JRLE 2 times a day improves glycemic control and lipid profile.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Walnut (Juglans regia) Leaf Extract on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

et al. 2022

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Numerous clinical trials have examined the beneficial effects of Juglans regia leaf extract (JRLE) in patients with type 2 diabetes mellitus (T2DM); however, the results of these studies are inconsistent. Therefore, we conducted the current systematic review and meta-analysis to evaluate the effect of JRLE on glycemic control and lipid profile in T2DM patients. We searched online databases including PubMed, Scopus, EMBASE, and Web of Science for randomized controlled clinical trials that examined the effect of JRLE on glycemic and lipid indices in T2DM patients. Data were pooled using both fixed and random-effect models and weighted mean difference (WMD) was considered as the overall effect size. Of the total records, 4 eligible studies, with a total sample size of 195 subjects, were included. The meta-analysis revealed that JRLE supplementation significantly reduces fasting blood glucose (WMD, −18.04; 95% confidence interval [CI], −32.88 mg/dL, −3.21 mg/dL; p = 0.017) and significantly increases fasting insulin level (WMD, 1.93; 95% CI, 0.40 U/L, 3.45 U/L; p = 0.014). Although the overall effect of JRLE supplementation on hemoglobin A1c was not significant, a significant reduction was seen in studies with an intervention duration of > 8 weeks (WMD, −0.64; 95% CI, −1.16%, −0.11%; p = 0.018). Moreover, we also found no significant change in lipid parameters. Our findings revealed a beneficial effect of JRLE supplementation on glycemic indices in T2DM patients, but no significant improvement was found for lipid profile parameters.

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“…4 Currently, the State Pharmacopoeia of the Russian Federation there is no pharmacopoeial article on medicinal plant raw materials -bark of walnut. 5,6 Thus, the study of indicators of quality of medicinal plants bark of walnut is relevant.…”

Section: Introductionmentioning

confidence: 99%

Study of Quality Medicinal Plants Bark Walnuts and Extract from it

Av¹,

Di²,

Луферов³

et al. 2020

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Objective: The bark of walnut is currently poorly understood and is not represented in the Russian State Pharmacopeia. The purpose was to study the quality indicators medicinal plants walnut crust and extracts therefrom were studied: moisture content, total ash, ash insoluble in 10% hydrochloric acid feedstock walnut crust; content of tannins and juglone in walnut crust; GC-mass spectrometric study of the composition petroleum extract from the bark of a walnut. Materials and Methods: Microscopy was prepared by the pharmacopoeial method. The chemical composition of the petroleum extract was investigated by chromatomass spectrometry. Results: The content of glycosides amount in terms of gidroyuglone glucoside and absolutely dry RL was 5.30 ± 0.15. Humidity was 9,41% ± 0,21. total ash content was 10,18% ± 0,1. The ash content insoluble in 10% hydrochloric acid was 4.8 ± 0.16. Gas chromatography-mass spectrometry method in petroleum extraction from the bark of walnut were identified following compounds: oktadetsilgeksanoat (28%) of 4-isopropenyl-1-methyl-2-cyclohexenol-1 (38%), cineole (1,6%), thujone (0.7%), camphor (16.6%), 2benzamidoantrahinone (0.45%), 4,5-dihydroxy-3,4-dihydro-1 (2H)-naftalenon (6.4%) ethyl ester of palmitic acid (8.25%) Toxic effects petroleum extract was TD 50 = 2,5. Chronic absent. All mice in the experimental group had diarrhea. It was established that the extraction has petroleum anthelmintic properties at askaridioze. Conclusions: The analysis of petroleum extraction from walnut partitions was carried out, the content of basic biologically active substances was revealed. The main anatomical and diagnostic signs of walnut bark walls were studied.

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Anti-hyperglycemic effect of aqueous extract of Juglans regia L. leaf (walnut leaf) on type 2 diabetic patients: A randomized controlled trial

Cited by 12 publications

References 29 publications

Phenolic profile, antioxidant and antibacterial properties of Juglans regia L. (walnut) leaves from the Northeast of Portugal

Phenolic profile, antioxidant and antibacterial properties of Juglans regia L. (walnut) leaves from the Northeast of Portugal

The Effect of Walnut (Juglans regia) Leaf Extract on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Study of Quality Medicinal Plants Bark Walnuts and Extract from it

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