Anti-hyperglycemic Potential of Natural Products

Matsui, Takanori; Ogunwande, Isiaka A.; Abesundara, Kanthi J. M.; Matsumoto, K.

doi:10.2174/138955706776073484

Cited by 127 publications

(111 citation statements)

References 32 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…Another study showed that acarbose is a good inhibitor for α-glucosidase [26]; our experiment showed similar results and inhibition capacity for α-amylase. Type-I α-glucosidase, derived from yeast, is usually of higher purity, while α-glucosidase, derived from rat small intestine, Type-II, mimics mammals more [27]. Inhibition ability of acarbose for type-II α-glucosidase is superior to that of type-I [17]; similar results were found in our experiment.…”

Section: Discussionsupporting

confidence: 88%

Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Wang¹,

Huang²,

Hsu³

et al. 2017

AJPS

View full text Add to dashboard Cite

Glossogyne tenuifolia (GT) is the traditional herbal tea in Penghu Island, Taiwan. Recent research has shown that the active components in GT are potential inhibitors of α-glucosidase. The present study investigated that whether or not GT could improve the status of type 2 diabetes mellitus. Male Wistar rats aged eight weeks were induced to be hyperglycemic by subcutaneous injection of streptozotocin-nicotinamide (STZ-NA) and combination of high-fat diet (HFD). The animals were given GT extracts at the low dose or high dose, or the anti-diabetic drug (acarbose), in drinking water for 4 weeks. The results showed that hot water extracts from GT resulted in significantly decreases in fasting blood glucose at the 1 st and 2 nd weeks, fasting insulin levels at the 2 nd week, 1 hour postprandial blood glucose after the starch tolerance test on Day 23 and blood glucose levels after oral glucose tolerance test (OGTT) at the 60 th minute on Day 25. In addition, diabetic rats treated with GT extracts from hot water for 4 weeks displayed significantly decreased thiobarbituric acid reactive substances (TBARS) in the serum, liver and kidney, serum total cholesterol, fasting insulin levels and homeostasis model assessment for insulin resistance (HOMA-IR). Overall, these results demonstrate that the hot water extracts of GT might improve the progression of diabetes and decrease oxidative stress in STZ-NA-induced diabetic rats.

show abstract

Section: Discussionsupporting

confidence: 88%

Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Wang¹,

Huang²,

Hsu³

et al. 2017

AJPS

View full text Add to dashboard Cite

show abstract

“…We assayed the ␣-glucosidase by the free enzyme system while Matsui et al (8) used the immobilized enzyme system developed by Oki et al (14). The significance of these two assay methods was discussed in a review article by Matsui et al (15).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Inhibitors of Postprandial Hyperglycemia from the Leaves of Nerium indicum

Ishikawa

Yamashita

Hiemori

et al. 2007

J Nutr Sci Vitaminol

125

View full text Add to dashboard Cite

Summary Nerium indicum is an India-Pakistan-originated shrub belonging to the oleander family. The ingestion of leaves of N. indicum before a meal is known to effect the lowering of postprandial glucose levels in Type II diabetic patients and this plant is now used as a folk remedy for Type II diabetes in some regions of Pakistan. In the present study, the hot-water extract of N. indicum leaves was found to reduce the postprandial rise in the blood glucose when maltose or sucrose was loaded in rats. It was also found that the extract strongly inhibited ␣ -glucosidase, suggesting that the suppression of the postprandial rise in the blood glucose is due to the occurrence of some inhibitors of ␣ -glucosidase in the leaves. We, therefore, tried to isolate the active principles from the leaf extract, using ␣ -glucosidase-inhibitory activity as the index. Employing Sephadex G-15, silica gel and reversed-phase HPLC, we isolated two active compounds. The UV, mass and NMR spectrometric analyses established that the chemical structures of these compounds are 3-O -caffeoylquinic acid (chlorogenic acid) and its structural isomer, 5-O -caffeoylquinic acid. Both compounds were shown to inhibit ␣ -glucosidases in a non-competitive manner. The authentic chlorogenic acid was found to suppress the postprandial rise in the blood glucose in rats and also inhibited the absorption of the glucose moiety from maltose and glucose in the everted gut sac system prepared from rat intestine. These results demonstrate that chlorogenic acid is one of the major anti-hyperglycemic principles present in the leaves of N. indicum . Furthermore, among polyphenol compounds tested, quercetin and catechins were shown to have strong inhibitory activity against ␣ -glucosidase.

show abstract

“…Há necessidade premente de se explorar o campo da fitomedicina para fornecer terapias alternativas no tratamento da síndrome diabética (80). A comunidade científica tem grande interesse em avaliar o estado do produto natural isolado em estudos experimentais, sendo que alguns deles já foram testados em seres humanos (81)(82)(83)(84).…”

Section: Pesquisa Translacional Em Dmg E Hgl Para Estudos De Intervençãounclassified

Pesquisa translacional em diabetes melito gestacional e hiperglicemia gestacional leve: conhecimento atual e nossa experiência

Rudge

Pículo

Marini

et al. 2013

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

RESUMOO diabetes materno constitui um ambiente desfavorável para o desenvolvimento embrionário e feto--placentário. É uma repercussão de importância na obstetrícia moderna, visto que está associado a um risco aumentado de morbidade materna e neonatal e continua a ser um desafio médico significativo. O aumento mundial na incidência do diabetes, o aumento do diabetes tipo 2 em mulheres em idade reprodutiva e a geração cruzada da programação intrauterina do diabetes tipo 2 são as bases para o interesse crescente na utilização de modelos experimentais diabéticos, a fim de obter conhecimento sobre os mecanismos que induzem as alterações de desenvolvimento no diabetes gestacional. Vários estudos têm demonstrado os benefícios da prevenção do diabetes com intervenções no estilo de vida, melhora metabólica e controle de fator de risco cardiovascular para evitar substancialmente as complicações devastadores da doença. Apesar desses achados e a revolução recente no conhecimento científico e infinidade de novas terapias do diabetes, continua a haver uma grande lacuna entre o que foi aprendido por meio da pesquisa e o que é feito na prática da saúde pública, clínica e comunitária. O iminente impacto econômico negativo dessa complacência nos indivíduos, nas famílias e nas economias nacionais é alarmante. Espera-se que a pesquisa translacional no binômio diabetes-gravidez seja implementada em centros de excelência tanto de pesquisa básica como aplicada e complementada por estudos clínicos multicêntricos, conduzidos de forma pragmá-tica para aumentar o nível de evidência científica com recursos diagnósticos e propedêuticos mais confiáveis. Arq Bras Endocrinol Metab. 2013;57(7):497-508 Descritores Diabetes; gestação; modelos animais; pesquisa translacional; incontinência urinária ABSTRACT Maternal diabetes constitutes an unfavorable environment for fetal-placental and embryonic development. It is has important repercussion in modern obstetrics, since it is associated to an increased risk of neonatal and maternal morbidity, and it still is a significant medical challenge. The increased occurrence of diabetes worldwide, the increase in diabetes type 2 in women at reproductive age and the crossed generation of intrauterine programming for diabetes type 2 are the bases for the growing interest in utilization of diabetic experimental samples, with the aim to acquire knowledge about the mechanisms that induce development alterations in gestational diabetes. Several studies have shown the benefits of diabetes prevention, with interventions in lifestyle, metabolic improvement and control of cardiovascular risk factors to substantially prevent the complications of this devastating disease. Despite these findings, the recent revolution in the scientific knowledge, and the infinite number of new therapies for diabetes, there is still a large gap between what was learned through research and what is really done in public, clinical and community health. The negative economic impact of this complacency in people, families, and national econom...

show abstract

Anti-hyperglycemic Potential of Natural Products

Cited by 127 publications

References 32 publications

Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Characterization of Inhibitors of Postprandial Hyperglycemia from the Leaves of Nerium indicum

Pesquisa translacional em diabetes melito gestacional e hiperglicemia gestacional leve: conhecimento atual e nossa experiência

Contact Info

Product

Resources

About

Anti-hyperglycemic Potential of Natural Products

Cited by 127 publications

References 32 publications

Hypoglycemic and Antioxidative Effects of &lt;i&gt;Glossogyne tenuifolia&lt;/i&gt; on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Hypoglycemic and Antioxidative Effects of &lt;i&gt;Glossogyne tenuifolia&lt;/i&gt; on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Characterization of Inhibitors of Postprandial Hyperglycemia from the Leaves of Nerium indicum

Pesquisa translacional em diabetes melito gestacional e hiperglicemia gestacional leve: conhecimento atual e nossa experiência

Contact Info

Product

Resources

About

Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats

Hypoglycemic and Antioxidative Effects of <i>Glossogyne tenuifolia</i> on Streptozotocin-Nicotinamide-Induced Diabetic Rats