Anti-hyperlipidaemic activity of fresh and old Guggulu (Commiphora wightii (Arn.) Bhandari) in experimental animals

Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats

“…Significant (P < 0.05) reductions in liver TC of H groups like H-EG and H-NEG were attributed to the respective effects of encapsulated and nonencapsulated guggul and constituents of the oil phase. The result was supported by the findings of Vyas et al (2014), Kumar et al (1999) and Bhaskaragoud et al (2016) who have reported effect of guggulsterone, cow ghee and rice bran oil on TC, respectively. Further, comparable (P > 0.05) results of liver TC in H-EG and H-NEG revealed no significant effect of encapsulating guggul in double emulsion matrix.…”

“…The result was supported by the findings of Vyas et al . (), Kumar et al . () and Bhaskaragoud et al .…”

“…Accordingly, Vyas et al . () showed ability of guggulsterones to enhance binding of LDL to its receptor in the liver membrane and catabolism of LDL through receptors. Wang et al .…”

“…In similar studies, guggulsterone regulated cholesterol level by either inhibiting cholesterol formation in liver or increasing the rate of cholesterol degradation (Pratap et al, 2015). It also showed inhibition of bile acid receptors activity and increases activity of LCAT (enzyme for lipoprotein metabolism) leading to positive regulation of plasma HDL-Ch levels (Ramesh & Saralakumari, 2012;Vyas et al, 2014). The only difference in the diets of H-EG and H-N-EG was the encapsulation of guggul extract in the double emulsion matrix.…”

“…The significantly different values of H-EG and N-EG could be because of enhanced effect of encapsulated guggul under H condition. Accordingly, Vyas et al (2014) showed ability of guggulsterones to enhance binding of LDL to its receptor in the liver membrane and catabolism of LDL through receptors. Wang et al (2004) further added that higher degradation of LDL by liver membrane was attributed to increased number of functional LDL receptor upon administration of guggulsterone (25 mg kg À1 day À1 ), rather than increased affinity of present receptors on liver membrane.…”