Anti Hyperlipidemic Activity of Bisindole Substituted Coumarin Derivatives

Abstract

Some Bis indole substituted coumarin derivatives prepared in 3 steps. The final compound III is react with different substituted indole compounds and aceto nitrile at room temperature for 30 minutes the compounds S1-S6 is obtained. The present investigation deals with the synthesized compounds having anti hyperlipidemic activity. Table 1 and 2 show the levels of Cholesterol, Triglycerides, HDL, LDL and VLDL of control and experiment rats respectively. Serum of hyperlipidemic rats showed significantly increased levels of Cholesterol, Triglycerides, LDL -C and low HDL -C, when compared with normal rats. In rats treated with various synthetic drugs and Atorvastatin there was significant decrease in the content cholesterol, TGs, LDL -C, and VLDL and increases HDL -C, when compared with cholesterol control rats.