Anti-Hypertensive Effect of Nigella Sativa Seeds in Patients with Hypertension

Abstract

Background: Hypertension (HTN) is an important public health problem. Antihypertensive drugs lead to side effects, possibly leading to non-compliance, thus uncontrolled hypertension as well as cardiovascular morbidity enhanced risk and death. Aim: To determine the effect of nigella sativa seeds in patients with hypertension at 0, 6 and 12 weeks; and to compare these effects with control patients on standard hypertension therapy. Study Design: Experimental study. Methodology: Present study enrolled 200 patients with hypertension (100 cases and 100 controls) visiting Services Hospital Lahore. Nigella sativa seeds were administered to 100 hypertensive patients who were on standard therapy in a dose of 1.5gms (once daily) orally for 12 weeks. Their blood pressure was recorded and compared to the 100 patients in control group taking standard therapy only at 0, 6, 12 weeks. Data was collected through questionnaire which was entered in computer using SPSS Results: Among cases, mean age was 45.16±10.544 years while in controls was 41.61±10.971 years. In case group, at 0 week, 6 weeks and 12 weeks, the mean systolic blood pressure (mmHg) was 139.49±6.337, 137.87±5.829 and 132.66±5.887 while mean diastolic blood pressure was 102.32±6.135, 100.58+6.081 and 95.26±6.594, respectively. In control group at 0 week, 6 weeks and 12 weeks, the mean systolic blood pressure (mmHg) was 139.07±6.307, 138.93±6.961 and 133.37±5.836 while mean diastolic blood pressure was 102.85±5.844, 102.75±5.518 and 95.64±6.850, respectively. Conclusion: We concluded that Nigella Sativa seeds have anti-hypertensive effect and significantly reduce the blood pressure among patients with hypertension. Keywords: Nigella Sativa, Seed, Effect, Patients and Hypertension

Antihypertensive effects of Nigella sativa supplementation: An updated systematic review and meta‐analysis of randomized controlled trials

“…Totally, 1527 subjects were included, and the dates of publications were between 2008 and 2022. Among the 22 studies, 19 were parallel studies (Amin et al, 2015; Bin Sayeed et al, 2013; Datau et al, 2010; Dehkordi & Kamkhah, 2008; Fallah Huseini et al, 2013; Hadi et al, 2021; Ibrahim et al, 2014; Mahdavi et al, 2015; Naeimi et al, 2020; Qidwai et al, 2009; Rachman & Darmawan, 2017; Rashidmayvan et al, 2019; Rashidmayvan et al, 2022; Rizka et al, 2018; Salem et al, 2021; Sayeed et al, 2014; Shoaei‐Hagh et al, 2021; Siddiqui et al, 2022; Tavakoli‐Rouzbehani et al, 2021), and three were crossover (Latiff et al, 2014; Mohtashami, 2019; Razmpoosh et al, 2021). The sample size ranged from 32 to 200 participants and the duration of the study ranged from 4 to 16 weeks.…”

“…The baseline BMI varied between 21.8 and 32.4 kg/m 2 . Studies were conducted in the following countries: Iran (Dehkordi & Kamkhah, 2008; Fallah Huseini et al, 2013; Hadi et al, 2021; Mahdavi et al, 2015; Mohtashami, 2019; Naeimi et al, 2020; Rashidmayvan et al, 2019; Rashidmayvan et al, 2022; Razmpoosh et al, 2021; Shoaei‐Hagh et al, 2021; Tavakoli‐Rouzbehani et al, 2021), Saudi Arabia (Badar et al, 2017; Salem et al, 2021), Indonesia (Datau et al, 2010; Rachman & Darmawan, 2017; Rizka et al, 2018), Pakistan (Amin et al, 2015; Qidwai et al, 2009; Siddiqui et al, 2022), Malaysia (Ibrahim et al, 2014; Latiff et al, 2014), and Bangladesh (Bin Sayeed et al, 2013; Sayeed et al, 2014). N. sativa in forms of powder (doses from 0.5 to 3 g/day) and oil (doses from 0.1 to 4.2 g/day) were used in the studies.…”