Anti-hyperuricemic and nephroprotective effects of Smilax china L.

Chen, Lvyi; Yin, Huafeng; Lan, Zhou; Ma, Shouxiang; Zhang, Chunfeng; Yang, Zhonglin; Li, Ping; Lin, Baoqin

doi:10.1016/j.jep.2011.03.033

Cited by 91 publications

(74 citation statements)

References 29 publications

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“…Another active ingredient Resveratrol, exhibits low OB value (19.07%). However, as the homolog of Oxyresveratrol, it is rather effective for anti-inflammation (Chen et al, 2011) and especially benefit for lowering UA by reducing the expression of UA synthetase XOD or transporters such as OAT1, GLUT9 . Therefore, it was added as potential ingredients for further analysis.…”

Section: Sgmentioning

confidence: 99%

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

Zhao

Yang³

et al. 2015

Journal of Ethnopharmacology

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Section: Sgmentioning

confidence: 99%

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

Zhao

Yang³

et al. 2015

Journal of Ethnopharmacology

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“…In vitro antioxidant properties of leaf extracts were shown in one study on Smilax china [37] after our research [23] . Nephroptotective activity of extracts obtained from S. china rhizomes in hyperuricemic animals was demonstrated in a recent study without histopathological observation [38] . Despite the many beneficial biological properties of Smilax excelsa, its protective effect against CCl 4 nephrotoxicity has not so far been explored.…”

Section: Discussionmentioning

confidence: 95%

“…Rhizomes of several Smilax species from this genus possess a variety of bioactivities including anticancer [2,3] , anticonvulsant [4] , antiinflammatory and antinociceptive [5][6][7] , hepatoprotective [8][9][10] , antihyperuricemic and nephroprotective [11] actions. A survey of the literature showed that several Smilax species contain phenylpropanoid glycosides [12] , anthocyanins [13] , flavonoid glucosides [2,14] and steroid saponins [15,16] .…”

Section: Introductionmentioning

confidence: 99%

Deneysel Olarak Oluşturulmuş Böbrek Hasarı Üzerine Smilax excelsa L. Kullanımının Değerlendirilmesi

Özsoy¹,

Okyar²,

Arda-Pirincci³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryThe protective effect of an aqueous extract of the shoots and leaves of Smilax excelsa L. against acute carbon tetrachloride (CCl 4 )-induced toxicity and the changes in antioxidative defense activities in kidney of rats were investigated. Female Wistar rats were supplied with S. excelsa shoots and leaves aqueous extract once a day for 9 days (orally at a dose of 100, 200 and 400 mg/kg of body weight) prior to renal injury induction through intraperitoneal injection with a single dose of CCl 4 (1 ml/kg body wt, in a 20 % v/v olive oil solution) on the 10th day. 24 h after CCl 4 intoxication serum and tissue biochemical and hispathological analyses were undertaken after sacrification under anesthesia. Administration of the extract reversed the antioxidant parameters which were impaired in CCl 4 group, in a dose dependent manner and at a dose of 400 mg/kg of body weight the levels of almost all the parameters were almost back to normal Control group. Nevertheless, the extract did not completely improve the CCl 4 -induced degenerative changes observed microscopically in kidney tissue. The results of this study suggest that S. excelsa could protect the kidney tissue against CCl 4 -induced nephrotoxicity in rats, probably by increasing antioxidative defense activities. Keywords: Smilax excelsa, Renal damage, Carbon tetrachloride, Antioxidant effect, Nephrotoxicity Deneysel Olarak Oluşturulmuş Böbrek Hasarı ÜzerineSmilax excelsa L. Kullanımının Değerlendirilmesi ÖzetBu çalışmada Smilax excelsa L. 'nın genç sürgün ve yapraklarının sulu ekstresinin sıçanlarda karbon tetraklorür (CCl 4 ) ile deneysel olarak oluşturulmuş böbrek hasarına olan etkisi ve antioksidan savunma sistemindeki değişiklikleri incelendi. Wistar albino dişi sıçanlara, 9 gün süre ile, S. excelsa extresinin 100, 200 ve 400 mg/kg dozunda oral olarak uygulanmasının ardından, 10. gününde CCl 4 'ün %20'lik zeytin yağındaki solüsyonunun 1ml/kg intraperitoneal verilmesiyle böbrek harabiyeti oluşturuldu. CCl 4 uygulanmasından 24 saat sonra, sıçanlar anestezi altında öldürüldü, ardından serum ve böbrek dokusunda biyokimyasal ve histopatolojik analizler yapıldı. CCl 4 grubunda bozulan tüm değerlerin, ekstrenin verilmesiyle doza bağlı olarak düzeldiği ve 400 mg/kg dozunda aşağı yukarı normal Kontrol grubu değerlerine ulaştığı gözlemlendi. Buna karşın, ekstre CCl 4 ile oluşturulan, böbrek dokusunda mikroskobik olarak gözlenen dejeneratif değişiklikleri tam olarak iyileştirmedi. Bu çalışmanın sonucunda, S. excelsa'nın sıçanlarda böbrek dokusunu CCl 4 ile oluşturulan hasardan koruduğu ve bu etkisini organizmanın antioksidan savunma sistemlerini arttırarak gösterdiği ileri sürülebilir.

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“…In this way, compounds with anti-inflammatory as well as antioxidant and antiarthritic activities were isolated from this genus, among them Smilaxchinoside A–D, Sieboldogenin, and Astilbin [9–11]. Phytochemical studies revealed the presence of saponins, flavonoids, phenolic compounds, tannins, alkaloids, and phenylpropanoids glucosides [2, 6, 7, 12]. …”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Antinociceptive, Anti‐Inflammatory, and Antioxidant Studies of Smilax larvata (Smilacaceae)

Hirota

Paula

Oliveira

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The tea of aerial parts of Smilax larvata Griseb. (Smilacaceae) has been ethnopharmacologically used in Southern Brazil due to its anti-inflammatory action. In this study, ethanolic and organic extracts from aerial parts of S. larvata were phytochemically and pharmacologically characterized. The phytochemical analysis of EtOAc extract of S. larvata revealed the presence of three flavonoids, drabanemoroside, kaempferol 3-O-α-L-rhamnopyranosyl(1→2)-α-L-rhamnopyranoside, and kaempferol, the first two being isolated for the first time in this genus, two phenolic compounds p-hydroxybenzoic acid and p-coumaric acid, and alkaloids. In vitro assays demonstrated a potential antioxidant property of SLG. The treatment with SLG induced a significant reduction of the formalin-evoked flinches in rats, an effect reversed by opioid antagonist naloxone. Treatment with SLG also induced a significant increase in the hot plate latency and a decrease of intestinal motility by 45%. No effect was observed over nociceptive responses induced by a TRPA1 agonist mustard oil or over acetic acid-induced writhing in mice. Together, our data suggested that SLG has an in vivo antinociceptive effect, which seems to be associated with the opioid system activation. These findings support previous claims of medical use of Smilax larvata in the treatment of pain conditions.

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Anti-hyperuricemic and nephroprotective effects of Smilax china L.

Cited by 91 publications

References 29 publications

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

Deneysel Olarak Oluşturulmuş Böbrek Hasarı Üzerine Smilax excelsa L. Kullanımının Değerlendirilmesi

Phytochemical and Antinociceptive, Anti‐Inflammatory, and Antioxidant Studies of Smilax larvata (Smilacaceae)

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