Anti-hyperuricemic and nephroprotective effects of Modified Simiao Decoction in hyperuricemic mice

Hua, Jian; Huang, Ping; Zhu, Changlian; Yuan, Xiao; Yu, Chunjing

doi:10.1016/j.jep.2012.04.052

Cited by 37 publications

(27 citation statements)

References 23 publications

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“…To be specific, EM is a classical formula used for clearing heat and eliminating dampness to treat gouty diseases through stimulating most core targets such as XOD, URAT1, IL-6, TNF-α, which are consistent with those collected from published literatures (Kong et al, 2004;Kao and Dong, 2013). As a classic formula derived from EM, SM is commonly used to treat gout and hyperuricemia in clinical (Hu et al, 2010;Hua et al, 2012), eliminating dampness, clearing heat and promoting blood circulation in terms of TCM through targeting UA synthetase, transporters and inflammatory cytokines. Literatures also suggest that SM could suppress inflammation and inhibit the release of IL-1β, TNF-α Liu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Basic prescription (SM), which is described in a famous TCM monograph Danxi Xinfa (comprehensive medical book), has been used for hundreds of years in Chinese medicine for treating gouty arthritis with eliminating dampness, clearing heat and promoting blood circulation (Hua et al, 2012;Shi et al, 2013). Therefore, the network (Fig.…”

Section: Explore the Rationality Of Herb Combinations Of Mswmentioning

confidence: 99%

“…Simiao (SM), a classical formula, which is derived from EM with additions AB and CS. According to Cheng-Fang-Bian-Du (a Chinese medicine book named Conventional Prescriptions for Easily Reading), SM is commonly used to treat gout through clearing heat, eliminating dampness and strengthening the liver and kidney in terms of TCM (Hu et al, 2010;Hua et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

Zhao

Yang³

et al. 2015

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Explore the Rationality Of Herb Combinations Of Mswmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

Zhao

Yang³

et al. 2015

Journal of Ethnopharmacology

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“…Therefore, the searches for more effective and less toxic agents against hyperuricemia are highly warranted. Natural products devoid of such disadvantages offer a great opportunity [32-37]. …”

Section: Introductionmentioning

confidence: 99%

Hypouricemic and Nephroprotective Effects of an Active Fraction from <b><i>Polyrhachis Vicina Roger</i></b> On Potassium Oxonate-Induced Hyperuricemia in Rats

Nong

et al. 2018

Kidney Blood Press Res

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Background/Aims: The objective of this study is to evaluate the hypouricemic and nephroprotective effects of an active fraction from Polyrhachis vicina Roger (AFPR) in potassium oxonate-induced hyperuricemic rats. Methods: Hyperuricemia was induced by potassium oxonate in male rats. AFPR was orally administered to hyperuricemic rats for 12 consecutive weeks. Serum, liver and kidney samples were collected for effects and mechanism analysis. The levels of serum uric acid (SUA) were measured by the phosphotungstic acid method, xanthine oxidase (XOD) activity in the hepatic and serum samples were measured by ultraviolet spectrophotometry, serum levels of interleukin-1 (IL-1β), interleukin-1 (IL-6) and tumor necrosis factor-α (TNF-α) were measured by ELISA, the levels of serum creatinine (SCr), blood urea nitrogen (BUN), super oxide dismutase (SOD) and malondialdehyde (MDA) in serum were determined by colorimetric method. Protein expression of renal URAT1, GLUT9, and OAT1 were analyzed by Western blot. Results: AFPR significantly decreased the levels of SUA, serum and hepatic XOD, SCr, BUN, and MDA as well as increased SOD. In addition, AFPR treatment significantly reduced the levels of proinflammatory cytokines in serum, including IL-1β, IL-6 and TNF-α. Moreover, we found the significant decrease in protein expression of URAT1 and GLUT9, and the significant increase in protein expression of OAT1 in the kidney in AFPR treated groups compared to the model groups of hyperuricemia. Conclusion: These findings suggest that AFPR has anti-hyperuricemic activity attributed to the inhibition of uric acid generation in the liver and probably to the enhancement of urate excretion in the kidney, and possess nephroprotective effect in hyperuricemic rats due to its anti-inflammatory and antioxidant activities.

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“…Despite advances in the use of antihyperuricemic agents for hyperuricemia and gout treatment, however, adverse effects such as severe hypersensitivity reactions associated with allopurinol and severe hepatotoxicity risk of benzbromarone limit their therapy usage [8].…”

Section: Introductionmentioning

confidence: 99%

Constituent and Antihyperuricemic Activity of Stelechocarpus Burahol Leaves Subfractions

Sunarni

Fidrianny²,

Iwo³

et al. 2017

Asian J Pharm Clin Res

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Objective: The goal of this research was to evaluate antihyperuricemic activity of Stelechocarpus burahol leaves subfractions and isolate its chemical constituent of active subfraction.Methods: Ethyl acetate fraction from S. burahol extract was subfractionated by vacuum liquid chromatography, and the active subfractions were further subfractionated by classic column chromatography using isocratic eluent, followed by isolated chemical constituent from active subfraction. Hyperuricemic rat model was induced by given potassium oxonate intraperitoneally. The inhibitory effect of subfractions on the xanthine oxidase (XO) activity was determined using ultraviolet-visible spectrophotometry method.Results: Subfractions E.3, E.4, and E.5 significantly (p<0.05) reduced the serum uric acid (UA) level 43%, 46%, and 33%, respectively. The E.3, E.4, and E.5 have showed very weak XO inhibitory activity. Subfraction E.3.2 and E.4.3 significantly (p<0.05) reduced the serum UA level 29% and 38%, respectively, however still very weak effect on XO activity. Chemical constituent which was isolated from subfraction E.4.3 was kaempferol-3-O-rhamnoside. Conclusion:The subfractions of ethyl acetate fraction had antihyperuricemic activity in vivo but less effect on XO activity in vitro. Isolated compound in active antihyperuricemic of subfraction E.4.3 was kaempferol-3-O-rhamnoside.

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Anti-hyperuricemic and nephroprotective effects of Modified Simiao Decoction in hyperuricemic mice

Cited by 37 publications

References 23 publications

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

Hypouricemic and Nephroprotective Effects of an Active Fraction from <b><i>Polyrhachis Vicina Roger</i></b> On Potassium Oxonate-Induced Hyperuricemia in Rats

Constituent and Antihyperuricemic Activity of Stelechocarpus Burahol Leaves Subfractions

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