Constituent and Antihyperuricemic Activity of Stelechocarpus Burahol Leaves Subfractions

Sunarni, Titik; Fidrianny, Irda; Iwo, Maria Immaculata; Wirasutisna, Komar Ruslan

doi:10.22159/ajpcr.2017.v10i4.17021

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…cumini leaves have two active flavonoid compounds that lower uric acid levels are quercetin and kaempferol [11]. The mechanism of action of the kaempferol inhibits xanthine oxidase by the inhibitory effects of them on xanthine oxidase activity [12]. Quercetin regulates renal organic ion transporters and uromodulin which play the important roles in renal urate excretion so that only a few uric acid is reabsorbed [13].…”

Section: Discussionmentioning

confidence: 99%

Antihyperuricemic Activity of Ethanol Extract of Syzygium Cumini Leaves on Potassium Oxonated-Induced Rats

Asiah

Rosidah

Yuandani

2018

Asian J Pharm Clin Res

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Objective: This study was conducted to investigate the effect of extract of Syzygium cumini on serum uric acid levels of rats induced by potassium oxonate.Methods: A total of 30 male Wistar rats were randomly divided into six groups, consist of one normal group (without treatment) and five groups that were induced by potassium oxonate 250 mg/kg bw intraperitoneally for 7 days. The ethanol extract of S. cumini leaves dose (100, 200, and 400 mg/kg bw) was administered orally 1 h after the potassium oxonate exposure during 7 days. On day 8, blood samples were collected for serum uric acid determination.Result: Ethanol extract of S. cumini leaves at doses of 100 mg/kg bw, 200 mg/kg bw, and 400 mg/kg bw significantly reduced serum uric acid as compared to negative control group of carboxymethylcellulose 0.5%.Conclusion: Ethanol extract of S. cumini leaves can be used as antihyperuricemic agent.

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Section: Discussionmentioning

confidence: 99%

Antihyperuricemic Activity of Ethanol Extract of Syzygium Cumini Leaves on Potassium Oxonated-Induced Rats

Asiah

Rosidah

Yuandani

2018

Asian J Pharm Clin Res

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“…The xanthine oxidase (XO) inhibitory effect of watermelon seed powder was spectrophotometrically assessed at 290 nm as per Yumita et al [30] and Sunarni et al [31], with minor modifications. Formation of uric acid was measured at 295 nm using the UV spectrometer; then, the activity of Xanthine oxidase was determined.…”

Section: Determination Of Xanthine Oxidase Inhibitory Activitymentioning

confidence: 99%

Remedial Action of Yoghurt Enriched with Watermelon Seed Milk on Renal Injured Hyperuricemic Rats

et al. 2022

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The consumption of plant-based dairy alternatives has increased rapidly around the world as a result of numerous positive health effects. Little information is available about the potential use of watermelon seed milk in the manufacture of yoghurt. The present study was undertaken to investigate the remedial action of yoghurt enriched with watermelon seed milk in renal injured hyperuricemic rats. A new yoghurt, substituting cow’s milk with different proportions of watermelon seed milk was prepared, followed by evaluation of its acceptability and functionality. Four different types of yoghurt were prepared from cow’s milk containing 3% fat, with different proportions of blended watermelon seed milk (0.0, 25, 50 and 75%). Sensorial traits, i.e., appearance, flavor, body and texture, and overall acceptability demonstrated that the blended treatment (50% cow’s milk and 50% watermelon seed milk.) was the most acceptable. This blend was then tested as an anti-hyperuricemia agent in rats. In this respect, twenty-four male albino rats were assigned into four groups (n = 6). The first group was solely administered a standard diet, and served as the negative control. The other rats (n = 18) received a basal diet including 20 g/kg dietary potassium oxonate in order to induce hyperuricemia. The hyperuricemic rats were then divided into three groups; the first group did not receive any treatment and served as the positive control, while the second and third groups were administered 10% cow’s milk yoghurt and 10% watermelon seed milk yoghurt, respectively. Interestingly, the results showed that the hyperuricemic group receiving a diet supplemented with 10% watermelon seed milk yoghurt was not significantly different from the negative control in the measured biological parameters, and saw a significant improvement in renal function compared to the positive control. The biologically favorable action of watermelon seed milk yoghurt could be attributed to its potential promotion of antioxidant status via enhancement of the activities of superoxide dismutase, catalase, and glutathione transferase. Collectively, this study concluded that watermelon seed milk can be used in yoghurt manufacturing in proportions of up to 50%, and may improve kidney function as an anti-hyperuricemic agent.

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“…Terapi alopurinol yang terutama digunakan untuk mengobati hiperurisemia dan komplikasinya memiliki efek samping hematologis, termasuk supresi sumsum tulang, anemia berat, trombositopenia, dan leukopenia, hal ini telah dilaporkan pada 0,2-0,6% pasien yang diobati, serta laporan kasus agranulositosis berat juga digambarkan akibat terapi (Mari et al, 2011 (Sunarni et.al., 2015). Sunarni et al, 2017 Sirsak (annona muricata L.)…”

Section: Pendahuluanunclassified

Review: Aktivitas Antihiperurisemia Dari Famili Annonaceae

Aditya

Nuari

Hasyul

2020

JPS

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Hiperurisemia adalah suatu kondisi dimana kadar asam urat dalam darah meningkat melebihi batas normal. Kondisi hiperurisemia atau gangguan metabolisme pada asam urat yang terjadi secara terus-menerus akan mendasari terjadinya Gout Arthritis. Di Indonesia, prevalensi penyakit sendi berdasarkan diagnosis dokter pada penduduk umur ≥ 15 tahun sebesar 7,3%, persentase penyakit sendi juga menempati posisi kedua terbesar setelah stroke pada prevalensi penyakit tidak menular di Indonesia berdasarkan diagnosis dokter pada penduduk umur ≥ 15 tahun dilihat dari hasil Riskesdas 2018. Selama satu dekade terakhir, beberapa spesies tanaman dari famili annonaceae seperti sirsak (Annona muricata L.), kepel (Stelechocarpus burahol (Bl.) Hook. F. & Th.), srikaya (Annona squamosa L.) dan nona (Annona reticulate L.) telah dilakukan penelitian mengenai aktivitas antihiperurisemia baik in vitro, in vivo, maupun uji klinik fase nol. Oleh karena itu, review ini akan membahas aktivitas antihiperurisemia dari beberapa spesies tanaman yang termasuk ke dalam famili annonaceae. Review ini bertujuan untuk memberikan informasi terkait aktivitas antihiperurisemia dari famili annonaceae berdasarkan studi literatur dari artikel-artikel penelitian sebelumnya. Pada review artikel ini digunakan literatur online dan offline. Literatur online didapat dari jurnal publikasi nasional maupun internasional yang diperoleh dari penyedia jurnal di internet. Literatur offline yang digunakan yaitu buku dan e-book. Hasil yang didapatkan yaitu beberapa spesies tanaman dari famili annonaceae seperti sirsak (Annona muricata L.), kepel (Stelechocarpus burahol (Bl.) Hook. F. & Th.), srikaya (Annona squamosa L.) dan nona (Annona reticulata L.) memiliki aktivitas antihiperurisemia melalui beberapa pengujian baik in vitro dengan uji daya hambat xantin oksidase, in vivo dengan menurunkan kadar asam urat pada hewan uji, serta uji klinik fase nol dengan eksperimental historis (pre-post design) pada responden. Oleh karna itu, diharapkan dapat menjadi alternatif pengobatan untuk hiperurisemia dan dikembangkan sebagai obat antihiperurisemia.Hyperuricemia is a condition wherein the level of uric acid in the blood increases beyond the normal limit. Condition of hyperuricemia or metabolic disorders in uric acid that occurs continuously the occurrence of Gout Arthritis. In Indonesia the prevalence of joint diseases based on the diagnosis of doctors in population age ≥ 15 years 7.3%, the percentage of joint disease also occupy the second largest after stroke in the prevalence of diseases not transmitted in Indonesia based on the diagnosis of doctors in the age population ≥ 15 years seen from the results Riskesdas 2018. Over the last decade, several species of plants from the annonaceae family such as soursop (Annona muricata L.), kepel (Stelechocarpus burahol (Bl.) Hook. F. & Th.), sweetsop (Annona squamosa L.) and custard apple (Annona reticulate L.) have been carried out research on the activity of antihyperuricemia in either in vitro, in vivo, or zero-phase clinical trials. Therefore, this review will discuss the activity of antihyperuricemia from several species of plants that belong to the annonaceae family. This Review aims to provide information regarding the activity of antihyperuricemia from the annonaceae family based on literary studies of previous research articles. In this article review used the online and offline literature. Online literature is obtained from national and international publications obtained journals from journal providers on the internet. The offline literature used is books and e-books. The results obtained are several species of plants from the annonaceae family such as soursop (Annona muricata L.), kepel (Stelechocarpus burahol (Bl.) Hook. F. & Th), sweetsop (Annona squamosa L.) and custard apple (Annona reticulata L.) have antihyperuricemia activities through several in vitro testing with xanthine oxidase inhibition tests, in vivo by lowering uric acid levels in animal tests, as well as a zero-phase clinical test with historical experimental (pre-post design) respondents. Therefore, it is hoped that it can be an alternative treatment for hyperuricemia and developed as an antihyperuricemia drug. Keywords: antihyperuricemia, uric acid, in vitro, in vivo, zero phase clinical trials

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Constituent and Antihyperuricemic Activity of Stelechocarpus Burahol Leaves Subfractions

Cited by 6 publications

References 17 publications

Antihyperuricemic Activity of Ethanol Extract of Syzygium Cumini Leaves on Potassium Oxonated-Induced Rats

Antihyperuricemic Activity of Ethanol Extract of Syzygium Cumini Leaves on Potassium Oxonated-Induced Rats

Remedial Action of Yoghurt Enriched with Watermelon Seed Milk on Renal Injured Hyperuricemic Rats

Review: Aktivitas Antihiperurisemia Dari Famili Annonaceae

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