Anti-Inflammation Effects of Low Intensity Laser Therapy on Monosodium Iodoacetate-induced Osteoarthritis in Rats

Abstract

Abstract.[Purpose] The purpose of this study was to investigate the effects of low intensity laser therapy (LILT) on inflammatory osteoarthritis in the knee joint of rats.[Subjects] Thirty Sprague-Dawley rats were randomly divided into 3 groups with 10 rats each: the normal, control, and LILT groups. The arthritis group was treated with LILT using a gallium-aluminum-arsenide diode laser over during 3 weeks. All treatments were applied once a day, 5 days per week for 21 days. The inflammation cytokine and the articular index were used to assess the arthritic symptoms. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the serum were used as outcome measures.[Results] The arthritis index points of rats in the LILT group were lower than that of the control group. Similarly, TNF-α, IL-1β, and IL-6 concentrations in serum were significantly decreased in the LILT group compared to the control group, which coincided with behavioral studies.[Conclusion] This study shows that LILT is capable of reducing inflammatory cytokine concentrations induced by monosodium iodoacetate osteoarthritis in rats.

The Effects of Laser Moxibustion on Knee Osteoarthritis Pain in Rats

“…37 Kim and Kim conducted a 3-week treatment using an 850 nm galliumaluminum-arsenide laser, resulting in the weight-bearing difference, PWMT, and PWL significantly reversed, and the serum levels of TNF-a, IL-1b, and IL-6 also decreased in a MIA-induced KOA model. 29 These results indicated that different parameters of laser intervention have differ-ent effects on MIA-induced KOA pain. Future studies should compare the parameters of laser, determining the optimal treatment parameters, producing long-lasting analgesic effects, and more importantly, reducing or replacing the use of drugs.…”

“…found that a low-intensity laser can inhibit inflammatory cell infiltration, reduce the expression of proinflammatory cytokines and produce antinociceptive effects. 29 Histopathology showed that a low-intensity laser could alleviate synovitis, cartilage injury, and subchondral bone destruction, which may have a certain cartilage protection effect. 30 However, most of the currently used low-intensity lasers are semiconductor lasers, and more importantly, they only have the effect of a ''light needle'' due to their limited thermal effects.…”

The Short-term Effect of PRP on Chronic Pain in Knee Osteoarthritis

“…In literature, different results are reported about the K-L grade and response to PRP treatment in knee osteoarthritis. [3,[23][24][25] However, today the prominent opinion is that PRP responses are better in low K-L grade patients with little joint and cartilage degeneration. [1,3,5] Factors such as the reduction of living cells and the anabolic response to growth factors, the loss of chondrocytes, the thinning of the cartilage plate, deficient muscular functions and joint instability due to increased ligament laxity could reduce the effectiveness of PRP as joint degeneration increases.…”

“…[3,[23][24][25] However, today the prominent opinion is that PRP responses are better in low K-L grade patients with little joint and cartilage degeneration. [1,3,5] Factors such as the reduction of living cells and the anabolic response to growth factors, the loss of chondrocytes, the thinning of the cartilage plate, deficient muscular functions and joint instability due to increased ligament laxity could reduce the effectiveness of PRP as joint degeneration increases. [1,12] It is believed that PRP might not have any direct effect on the anabolic process in chondrocytes in the advanced stages of OA but that it may have an anti-inflammatory effect through the regulation of common homeostasis and cytokine levels.…”

“…[1] On the histopathology of OA, the joint becomes degraded as a result of the shift in the balance between injury and repair mechanisms in favor of inflammatory cytokines (IL-1, TNF-alpha) and the deficiency of the synthesis of anti-inflammatory cyto-kines (IL-4, IL-10). [2,3] Knee osteoarthritis is a significant health issue common in old age that runs with pain and functional limitations. It has been reported that conservative treatments (physical therapy practices, topical or oral non-steroidal anti-inflammatory drugs (NSAIDs), and intraarticular (IA) injections) increase the life quality of patients, particularly at early stages PAIN A RI of knee osteoarthritis.…”