Anti-Inflammation Role for Mesenchymal Stem Cells Transplantation in Myocardial Infarction

Guo, Jun; Lin, Guosheng; Bao, Chunyan; Hu, Zhimin; Hu, Mingyan

doi:10.1007/s10753-007-9025-3

Cited by 143 publications

(102 citation statements)

References 29 publications

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“…Recent animal studies in a model of experimental autoimmune encephalomyelitis demonstrated that MSC treatment results in a significantly milder disease and fewer relapses compared with control mice, with a decreased number of inflammatory infiltrates and reduced demyelination and axonal loss (Gerdoni et al, 2007;Zappia et al, 2005). Additionally, Guo et al (2007) reported that MSC transplantation decreases protein production and gene expression of inflammation cytokines and increases functional recovery from myocardial infarcts. These studies suggest that the anti-inflammatory actions of MSCs may be one underlying mechanism of the tissue-protective effect.…”

Section: Discussionmentioning

confidence: 99%

“…Recent reports have shown that the neuroprotective effect of MSCs may be mediated not only by their differentiation into neuron-like cells, but also by their ability to produce various trophic factors that may contribute to functional recovery, neuronal cell survival, and stimulation of endogenous regeneration (Barry and Murphy, 2004). Of these, the anti-inflammatory role of MSCs in cell transplantation as a protective mechanism has been demonstrated in vitro and in animal models of ischemic heart disease and experimental autoimmune encephalomyelitis (Gerdoni et al, 2007;Guo et al, 2007;Zappia et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti‐inflammatory action

Kim

Park

Lee

et al. 2008

Glia

214

170

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Parkinson's disease (PD) is a common, progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (SN). Numerous studies have provided evidence suggesting that neuroinflammation plays an important role in the pathogenesis of PD. In this study, we used lipopolysaccharide (LPS)-induced in vitro and in vivo inflammation models to investigate whether human mesenchymal stem cells (hMSCs) have a protective effect on the dopaminergic system through anti-inflammatory mechanisms. The hMSC treatment significantly decreased LPS-induced microglial activation, tumor necrosis factor (TNF)-a, inducible nitric oxide synthase (iNOS) mRNA expression, and production of NO and TNF-a compared with the LPS-only treatment group. In co-cultures of microglia and mesencephalic dopaminergic neurons, hMSC treatment significantly decreased the loss of tyrosine hydroxylase-immunopositive (TH-ip) cells. The hMSC treatment in rats showed that TH-ip neuronal loss induced by LPS stimulation in the SN was considerably decreased and was clearly accompanied by a decrease in activation of microglia, as well as TNF-a and iNOS mRNA expression and production of TNF-a. These data suggest that hMSCs have a neuroprotective effect on dopaminergic neurons through anti-inflammatory actions mediated by the modulation of microglial activation. Along with various trophic effects and trans-differentiational potency, the anti-inflammatory properties of MSCs could have major therapeutic implications in the treatment of PD. V V C

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti‐inflammatory action

Kim

Park

Lee

et al. 2008

Glia

214

170

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“…Therefore, their therapeutic effect did not appear to result from their direct integration into or reconstitution of host tissues. Rather, it now appears that MSCs promote tissue repair by secreting soluble factors that block apoptosis, [20][21][22] inflammation, [23][24][25][26] other immune cell-mediated responses, 27 and also stimulate the growth of host cells. 28 Therefore, the cells appear to function in tissue repair in a manner similar to their well established role in regulating hematopoiesis in bone marrow.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Heterogeneity of Mesenchymal Stem Cell Populations: Clues to their Therapeutic Efficacy

2007

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Mesenchymal stem cells (MSCs) have demonstrated therapeutic efficacy in a variety of disease models and human clinical trials. The widespread benefits of MSCs have recently been attributed to their capacity to secrete soluble factors that promote tissue repair by stimulating angiogenesis and suppressing inflammation, apoptosis, and immune cell function. However, these functional attributes are inconsistent with the designation of MSCs as stem cells, which by definition lie at the apex of a hierarchy of lineage specification and cellular differentiation. Previously, we catalogued the MSC transcriptome via serial analysis of gene expression to gain better insight into their basic biology. This analysis revealed that MSCs express a diverse range of proteins regulating angiogenesis, cell motility and communication, hematopoiesis, neural activities, immunity and defense. Furthermore, we reported that different classes of expressed regulatory proteins are restricted to distinct subpopulations of MSCs. Based on these findings we proposed that the molecular heterogeneity of the MSC transcriptome reflects the functional complexity of marrow stroma as an organ system in vivo and this complexity accounts for the broad therapeutic effects of MSCs. Examples are provided to illustrate how unique traits of MSC subpopulations from marrow may be exploited to develop more potent cellular vectors for therapy.

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“…These cells have attracted significant attention as a potential therapeutic agent for tissue repair due to their ability to migrate to the damaged tissue. 6,7 Recent experimental studies have showed that MSC can efficiently attenuate inflammatory processes, for instance, myocardial infarction 8 and acute lung injury. 9 It was shown that MSC transplantation in a rat model of myocardial infarction decreased the expression of inflammatory cytokines such as TNF-α, IL-1β, and IL-6.…”

Section: Introductionmentioning

confidence: 99%

“…9 It was shown that MSC transplantation in a rat model of myocardial infarction decreased the expression of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. 8 In an acute lung injury model, it was observed that MSC therapy reduced the levels of pro-inflammatory cytokines, increased the level of antiinflammatory cytokines in the plasma and bronchoalveolar lavage. 9 We aimed to determine the effect of MSC transplantation on the peritoneal morphology and inflammation markers in rat models of PD.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Inflammation by Mesenchymal Stem Cell Transplantation in Peritoneal Dialysis in Rats

et al. 2012

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Aim: The purpose of this study was to determine the effect of mesenchymal stem cell (MSC) transplantation on the peritoneal morphology and inflammation markers in rat models of peritoneal dialysis (PD). Materials and methods: Wistar albino rats were divided into two groups: control (C) (n ¼ 8) and experimental groups (n ¼ 50). PD solution was given to the experimental group during 6 weeks. Then, experimental group was divided into three groups as PD, MSC, and placebo (P) groups. MSC group was treated with MSC (1.5 Â 10 6 cells/kg) and P group was treated with phosphate buffer solution via intraperitoneal injection. Evaluation was performed to C and PD groups at the end of 6 weeks and to MSC and P groups at second and third week of the treatment (MSC-2, P-2, MSC-3, and P-3 groups). Results: The submesothelial area was significantly thickened in PD and P groups compared to C and MSC groups. Peritoneal fibrosis was seen in P-3 group but not in MSC group. There were no significant differences between the MSC-3 and C groups according to morphological findings. Levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were significantly increased in MSC-2 group compared to the other groups (p-values ranged from 0.0001 to 0.04). TNF-α and IL-6 levels in MSC-3 and P-3 groups were lower than PD and C groups (p < 0.0001 for TNF-α and p ¼ 0.0001-0.002 for IL-6). Conclusion: Giving MSC may protect the peritoneal membrane from the deleterious effect of PD and extend the life of the peritoneal membrane. Our study is the first on this issue and more detailed studies are needed.

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Anti-Inflammation Role for Mesenchymal Stem Cells Transplantation in Myocardial Infarction

Cited by 143 publications

References 29 publications

Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti‐inflammatory action

Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti‐inflammatory action

Biochemical Heterogeneity of Mesenchymal Stem Cell Populations: Clues to their Therapeutic Efficacy

Modulation of Inflammation by Mesenchymal Stem Cell Transplantation in Peritoneal Dialysis in Rats

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