Anti-inflammatory action of an alkaloid, fraction and extract from Alchornea glandulosa in mice

Formagio-Neto, Frederico; Volobuff, Carla Roberta Ferreira; Pederiva, Milena Menezes Corrêa; Pereira, Zefa Valdevina; Sarragiotto, María Helena; Cardoso, Cláudia Andréa Lima; Kassuya, Cândida Aparecida Leite; Formagio, Anelise Samara Nazari

doi:10.1016/j.jep.2018.11.001

Cited by 9 publications

(3 citation statements)

References 34 publications

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“… 2019 ; Formagio-Neto et al. 2019 ). Dexamethasone, a synthetic glucocorticoid, induces anti-inflammatory effects through inhibition of the NF-κΒ signalling pathway (Chen et al.…”

Section: Discussionmentioning

confidence: 99%

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice

Jeong

Choi

Kwon

et al. 2022

Pharmaceutical Biology

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Context Pinus densiflora Siebold & Zucc. (Pinaceae) needle extracts ameliorate oxidative stress, but research into their anti-inflammatory effects is limited. Objective To investigate antioxidant and anti-inflammatory effects of a Pinus densiflora needles (PINE) ethanol extract in vitro and in vivo . Materials and methods We measured levels of reactive oxygen species (ROS), superoxide dismutase (SOD) and inflammatory mediators in lipopolysaccharide (LPS)-stimulated RAW264.7 cells at various PINE concentrations (25, 50 and 100 μg/mL; but 6.25, 12.5 and 25 μg/mL for interleukin-1β and prostaglandin E 2 (PGE 2 )). Thirty ICR mice were randomized to six groups: vehicle, control, PINE pre-treatment (0.1, 0.3 and 1 mg/left ear for 10 min followed by arachidonic acid treatment for 30 min) and dexamethasone. The posttreatment ear thickness and myeloperoxidase (MPO) activity were measured. Results PINE 100 μg/mL significantly decreased ROS (IC 50 , 70.93 μg/mL, p < 0.01), SOD (IC 50 , 30.99 μg/mL, p < 0.05), malondialdehyde ( p < 0.01), nitric oxide (NO) (IC 50 , 27.44 μg/mL, p < 0.01) and tumour necrosis factor-alpha ( p < 0.05) levels. Interleukin-1β ( p < 0.05) and PGE 2 ( p < 0.01) release decreased significantly with 25 μg/mL PINE. PINE 1 mg/ear inhibited LPS-stimulated expression of cyclooxygenase-2 and inducible NO synthase in RAW264.7 macrophages and significantly inhibited ear oedema (36.73–15.04% compared to the control, p < 0.01) and MPO activity (167.94–105.59%, p < 0.05). Discussion and conclusions PINE exerts antioxidant and anti-inflammatory effects by inhibiting the production of inflammatory mediators. Identified flavonoids such as taxifolin and quercetin glucoside can be attributed to effect of PINE.

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“… 2019 ; Formagio-Neto et al. 2019 ). Dexamethasone, a synthetic glucocorticoid, induces anti-inflammatory effects through inhibition of the NF-κΒ signalling pathway (Chen et al.…”

Section: Discussionmentioning

confidence: 99%

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice

Jeong

Choi

Kwon

et al. 2022

Pharmaceutical Biology

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“…Machado et al also showed an in vivo analysis of the anti-inflammatory capacity of C. hololeuca extracts on carrageenan-induced paw edema in mice Balb/c, demonstrating the benefits in reducing the edema on these animals. The mechanism that explains this action is related to the capacity of the extracts in reducing pro-inflammatory mediators [57] mainly because of the presence of gallic and caffeic acid, as it was previously shown to be responsible for reducing edema inflammation [63,64].…”

Section: Daga Et Almentioning

confidence: 99%

A Review of the Anti-Inflammatory and Antimicrobial Activities of the Components of the Cecropia Genus

Daga

Ayala

Menolli

2020

Asian J Pharm Clin Res

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The genus Cecropia belongs to the Urticaceae family and has a wide diversity of species in several regions of South America. In folk medicine, they have many uses, such as hypoglycemic, antihypertensive, anti-inflammatory, and sedative. Species of the genus Cecropia, such as Cecropia pachystachya, Cecropia glaziovii, and Cecropia obtusifolia, have been the subject of several phytochemical studies, and the main isolated compounds were orientin, isoorientin, isovitexin, vitexin, as well as c-glycosylflavonoid compounds. These active compounds were characterized as responsible for the use of Cecropia plants in the treatment of inflammation and also as antimicrobial agents. This review aims to describe the main characteristics of the genus Cecropia, exploring the compounds responsible for the medicinal uses of these species and focusing on anti-inflammatory and antimicrobial uses.

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“…According to Luengas-Caicedo and colleagues ( 2007), the species Embaúba, Cecropia glaziovi Snethlage (Cecropiaceae), is used in Latin America for its anti-hypertensive, cardiotonic, diuretic and anti-asthma potential. For the species Tapiá (Alchornea glandulosa), reports of its potential used for immune-mediated inflammatory diseases (Formagio-Neto, et al, 2019). Whereas the species Erythrina crista-galli L. (Fabaceae), known in Brazil as suinã, is used in popular argentine medicine as anti-inflammatory, narcotic, disinfectant and for wound treatment (Weber, et al, 2005).…”

Section: Medical Potential Of Embu-verde Epamentioning

confidence: 99%

Review of the medicinal potential of the Flora of Embu-Verde Environmental Preservation Area

Sousa

Pezuk

Grecco³

2021

RSD

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The Atlantic Forest Biome is essential for 72% of the Brazilian population, but only a small part of the population has knowledge and values this environmental heritage. This biome is under constant threat; thus, strategies and actions are needed for its preservation and conservation. The Embu-Verde Environmental Preservation Area (EPA) concentrates a big part of the remaining biodiversity of the Atlantic Forest, and because it is close to the largest urban center in the country, it is increasingly threatened. The use of plants as a medicinal tool has been explored since the beginning of mankind. In fact, many of the compounds used in the health area derive from the flora. In this context, this study aimed to identify the medicinal potential of the EPA Embu-Verde flora, from the perspective that it is necessary to know to be able to preserve. Based on previous studies registering the biodiversity of EPA Embu-Verde, all the species of flora listed were investigated to identify its medicinal potential. We show here that of the 202 native species identified in the EPA Embu-Verde, there are 35 species of 23 botanical families that presented medicinal potential. The Myrtaceae family was the most cited, and its anti-inflammatory potential was the most prominent, moreover, several other uses were reported for the remaining flora. The medicinal potential of the flora of EPA Embu-Verde is still underestimated, therefore the recognition of medicinal species by the population is important. The preservation of the flora is essential to guarantee the possibility of future bioprospecting studies that will investigate the therapeutic potential of the still unknown medicinal species.

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Anti-inflammatory action of an alkaloid, fraction and extract from Alchornea glandulosa in mice

Cited by 9 publications

References 34 publications

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice

Extract of Pinus densiflora needles suppresses acute inflammation by regulating inflammatory mediators in RAW264.7 macrophages and mice

A Review of the Anti-Inflammatory and Antimicrobial Activities of the Components of the Cecropia Genus

Review of the medicinal potential of the Flora of Embu-Verde Environmental Preservation Area

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