Anti-Inflammatory Active Polyacetylenes from<i>Bidens campylotheca</i>

Redl, K.; Breu, W.; Davis, Bruce A.; Bauer, R.

doi:10.1055/s-2006-959409

Cited by 79 publications

(45 citation statements)

References 6 publications

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“…All parts of B. pilosa plant, the whole plant, the aerial parts (leaves, flowers, seeds, and stems), and/or the roots, fresh or dried, are used as ingredients in folk medicines. Dry powder, decoction, maceration, and tincture are usual formulations for its internal as well as external use [19]. B. pilosa can be used alone or together with other medicinal herbs.…”

Section: Botanical Propertiesmentioning

confidence: 99%

Botanical, Pharmacological, Phytochemical, and Toxicological Aspects of the Antidiabetic Plant Bidens pilosa L.

Yang

2014

Evidence-Based Complementary and Alternative Medicine

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Bidens pilosa L. is an easy-to-grow, widespread, and palatable perennial on earth. Hence, it has traditionally been used as foods and medicines without noticeable adverse effects. Despite significant advancement in chemical and biological studies of B. pilosa over the past few years, comprehensive and critical reviews on its anti-diabetic properties are missing. The present review is to summarize up-to-date information on the pharmacology, phytochemistry, and toxicology of B. pilosa, in regard to type 1 diabetes and type 2 diabetes from the literature. In addition to botanical studies and records of the traditional use of B. pilosa in diabetes, scientific studies investigating antidiabetic action of this species and its active phytochemicals are presented and discussed. The structure and biosynthesis of B. pilosa and its polyynes in relation to their anti-diabetic action and mechanism are emphasized. Although some progress has been made, rigorous efforts are further required to unlock the molecular basis and structure-activity relationship of the polyynes isolated from B. pilosa before their clinical applications. The present review provides preliminary information and gives guidance for further anti-diabetic research and development of this plant.

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Section: Botanical Propertiesmentioning

confidence: 99%

Botanical, Pharmacological, Phytochemical, and Toxicological Aspects of the Antidiabetic Plant Bidens pilosa L.

Yang

2014

Evidence-Based Complementary and Alternative Medicine

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“…Derivatives containing more than one acetylene group, such as heptadeca-2E,8E,10E,16-tetraene-4,6-diyne, heptadeca-2E,8Z,10E,16-tetraene-4,6-diyne, heptadeca-2E,8E,16-triene-4,6-diyne-10-ol, and safynol from Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) [194], or 11(S),16(R)-dihydroxy-octadeca-9Z,17-diene-12,14-diyn-1-yl acetate from Angelica pubescens f. biserrata [52] are more efficient. Potent derivatives are cis-hexadec-11-ene-7,9-diynoic acid 108 and cis-octadec-12-ene-7,9-diynoic acid 109 [195], falcarindol 110 and panaxynol 111 from Saposhnikoviae [52], [196] that block 5-LO product synthesis with IC 50 values of 2 ± 10 mM.…”

Section: Alkaloidsmentioning

confidence: 99%

Inhibition of 5-Lipoxygenase Product Synthesis by Natural Compounds of Plant Origin

Werz¹

2007

Planta Med

155

135

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The biosynthesis of leukotrienes (LTs) is initiated by the transformation of free arachidonic acid to LTA 4 by 5-lipoxygenase (5-LO). Subsequent enzymatic conversion of LTA 4 yields LTB 4 and the cysteinyl-LTs C 4 , D 4 and E 4 . LTs have prominent functions in pathophysiology and are connected to numerous disorders including bronchial asthma, allergic rhinitis, inflammatory bowel and skin diseases, rheumatoid arthritis, cancer, osteoporosis and cardiovascular diseases. Pharmacological and genetic interruption of the 5-LO pathway or blockade of LT receptors, serving as means for intervention with LTs, may be of therapeutic value for certain related disorders. Natural or plant-derived substances were among the first 5-LO inhibitors identified in the early 1980 s. To date, a huge number of diverse plant-derived compounds have been reported to interfere with 5-LO product synthesis. However, many investigations have addressed the efficacy of a given compound solely in cellular test systems and analysis of direct interference with 5-LO has been neglected. In the first part of this review, the biology and molecular pharmacology of the 5-LO pathway is summarized in order to understand its overall regulation and complexity as well as to comprehend the possible points of attack of compounds that eventually lead to inhibition of 5-LO product formation in intact cells. In the second part, natural compounds that interfere with 5-LO product formation are compiled and grouped into structural classes, and the underlying molecular mechanisms and structureactivity relationships are discussed.

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“…The interest in the phytochemical study of the species belonging to the genus Bidens (Astereaceae) derives from the fact that several of them, particularly those widely used in popular medicine, have been reported to have significant pharmacological and therapeutics properties [1][2][3][4]. Bidens subalternans D.C., popularly known as "amor seco" is an annual herb widely distributed in the northern and central parts of Argentina.…”

Section: Introductionmentioning

confidence: 99%

Chemical Components and Biological Activity of Bidens Subalternans, B. Aurea (Astereaceae) and Zuccagnia Puntacta (Fabaceae)

2000

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Anti-Inflammatory Active Polyacetylenes fromBidens campylotheca

Cited by 79 publications

References 6 publications

Botanical, Pharmacological, Phytochemical, and Toxicological Aspects of the Antidiabetic Plant Bidens pilosa L.

Botanical, Pharmacological, Phytochemical, and Toxicological Aspects of the Antidiabetic Plant Bidens pilosa L.

Inhibition of 5-Lipoxygenase Product Synthesis by Natural Compounds of Plant Origin

Chemical Components and Biological Activity of Bidens Subalternans, B. Aurea (Astereaceae) and Zuccagnia Puntacta (Fabaceae)

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