Anti-inflammatory activities of aqueous/ethanol and methanol extracts of Perna viridis Linn. in mice

Sreejamole, K. L.; Radhakrishnan, C. K.; Padikkala, José

doi:10.1007/s10787-010-0075-z

Cited by 14 publications

(5 citation statements)

References 16 publications

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“…During the initial phase (also called neurogenic phase) substance P and bradykinin are released, while in the second phase histamine, serotonin, prostaglandins, and bradykinin are involved ( 35 ). Anti-inflammatory effect of HESP on the formalin test, particularly in the neurogenic phase, led us to evaluate the effect of extract in another neurogenic inflammatory test (xylene-induced ear edema).…”

Section: Discussionmentioning

confidence: 99%

Anti-inﬂammatory Activity of Stachys Pilifera Benth

Sadeghi¹,

Zarezade²,

Sadeghi³

et al. 2014

Iran Red Crescent Med J

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Background:Stachys piliferaBenth has long been used to treat infectious diseases as well as respiratory and rheumatoid disorders in Iranian folk medicine. Antioxidants, antitumor, and antimicrobial properties of the plant have been reported.Objectives:This experimental study was designed to evaluate systemic and topical anti-inflammatory effects of the hydro-alcoholic extract from aerial parts of Stachys pilifera (HESP).Materials and Methods:Anti-inflammatory effects of HESP was studied in four well-known animal models of inflammation, including carrageenan- or formalin-induced paw edema in rat (thirteen groups, 6 rats per each group), and 12-O-tetradecanoylphorbol-13-acetate (TPA)- or xylene-induced ear edema in mouse (ten groups, 6 mice per each group). The rats received HESP (50-400 mg/ kg) orally 45 minutes before the subplantar injection of carrageenan or formalin. In TPA or xylene tests, HESP (1, 2.5, and 5 mg/ear) was applied topically simultaneous with these phlogistic agents on the ear mice. Finally, pathological examination of the inflamed tissues (paw and ear) was carried out.Results:Acute toxicity study of the extract showed that no rats were killed at 5000 mg/kg (LD50 > 5000 mg/kg). The extract (100 and 200 mg/ kg) significantly suppressed carrageenan-induced paw edema 1, 2, 3, and 4 hours after carrageenan challenge in comparison with the control group (P < 0.001). The HESP (100 and 200 mg/kg) also produced a considerable antiedematogenic effect in the formalin test over a period of 24 hours (P < 0.01). Furthermore, topical administration of the HESP (1, 2.5, and 5 mg/ear) inhibited TPA- and xylene-induced ear edema in comparison with the control group (P < 0.001). The pathological analysis of the paws and ears revealed that HESP was capable of reducing tissue destruction, cellular inﬁltration, and subcutaneous edema induced by the indicated phlogistic agents.Conclusions:The present data confirmed systemic and topical anti-inflammatory effects of Stachys pilifera which is comparable to indomethacin.

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Section: Discussionmentioning

confidence: 99%

Anti-inﬂammatory Activity of Stachys Pilifera Benth

Sadeghi¹,

Zarezade²,

Sadeghi³

et al. 2014

Iran Red Crescent Med J

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“…Ink extract of S. officinalis displayed anti-inflammatory potentials ( Soliman et al, 2015 ). Anti-inflammatory activity of mussel, Coelatura aegyptiaca was evaluated by Fahmy and Soliman (2013) , whereas the methanol, ethanol, and aqueous extracts of P. viridis exhibited anti-inflammatory properties in different in vivo models ( Sreejamole, Radhakrishnan, & Padikkala, 2011 ). Earlier studies of freeze-dried extract of New Zealand green-lipped mussel P. canaliculus exhibited the capacity to prevent the induced inflammation.…”

Section: Pharmacodynamic Studies and Therapeutic Applications Of Marimentioning

confidence: 99%

High-value compounds from the molluscs of marine and estuarine ecosystems as prospective functional food ingredients: An overview

Chakraborty

Joy

2020

Food Research International

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“…30 The occurrence of polyphenols and saponins in the extract of P. viridis using methanol as solvent have been studied and published. 4,31 Gallic acid is a possible identifier of the polyphenol compound because they are commonly isolated from mytilids as part of their endogenous defense system. 32 Meanwhile, further identification of the saponin compound present in this study is needed as there are no published reports of the occurrence of novel saponins from P. viridis.…”

Section: Discussionmentioning

confidence: 99%

Zoochemical Analyses and In vitro Antimicrobial Activity of Crude Methanolic Extract of Perna viridis

2021

Acta Med Philipp

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Introduction. The rise of antibiotic resistance and superbugs drives the search for new antibiotics today. Meanwhile, the green mussel Perna viridis is a cultivated and marketed staple bivalve in the Philippines due to its fast reproduction, high protein content, and tolerance to environmental variables. Although some studies have analyzed the antimicrobial activity of P. viridis, zoochemical analyses and further evaluation of its antimicrobial activity, such as determining the minimum inhibitory concentration (MIC), remains unexplored.Objectives. The study evaluated the zoochemicals present in crude methanolic extract of P. viridis by qualitative screening and thin-layer chromatography analysis. It further evaluated the crude extract for its antimicrobial activity against common pathogenic bacteria and plant pathogenic fungi. Materials and Methods.The zoochemicals in crude methanolic extract of P. viridis were screened using qualitative spotting methods and thin-layer chromatography (TLC). The antimicrobial activity of the extract was evaluated against the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis, and the fungi Colletotrichum capsici, Lasiodiplodia theobromae, and Rhizopus sp. using disk diffusion assay and two-fold microdilution.Results. Qualitative screening and thin-layer chromatography analysis of the crude extract revealed detectable amounts of alkaloids, saponins, terpenoids, sterols, and polyphenols. All of the tested bacteria were susceptible to the extract with P. aeruginosa (19.00±0.82 mm) and S. aureus (19.33±0.47 mm) as the most inhibited with MICs of 2.60±0.63 and 3.65±1.69 mg/mL, respectively. However, for the three fungi tested, only the growth of the fungus L. theobromae (7.33±0.94 mm) was inhibited with a MIC of 33.33±11.79 mg/mL. Conclusion.It can be inferred that the zoochemicals detected in the crude extract of P. viridis contributed to its antimicrobial activity.

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Anti-inflammatory activities of aqueous/ethanol and methanol extracts of Perna viridis Linn. in mice

Cited by 14 publications

References 16 publications

Anti-inﬂammatory Activity of Stachys Pilifera Benth

Anti-inﬂammatory Activity of Stachys Pilifera Benth

High-value compounds from the molluscs of marine and estuarine ecosystems as prospective functional food ingredients: An overview

Zoochemical Analyses and In vitro Antimicrobial Activity of Crude Methanolic Extract of Perna viridis

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