Anti-inflammatory activities of Dangyuja (Citrus grandis Osbeck) in concanavalin A stimulated murine splenocytes and 12-O-tetradecanoylphorbol-13-acetate-induced murine skin edema

Herath, Kalahe Hewage Iresha Nadeeka Madushani; Bing, So Jin; Cho, Jin-Hee; Kim, Areum; Shin, Sumin; Kim, Gi-Ok; Lee, Jong-chul; Jee, Youngheun

doi:10.1016/j.biopha.2016.08.042

Cited by 11 publications

(3 citation statements)

References 35 publications

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“…Recently, interests in potent pharmacological properties and clinical applications of natural products for replacing synthetic drugs are mounting. 33 In spite of major scientific and technological progress in combinatorial chemistry, drugs derived from natural products still make an enormous contribution to drug discovery today. 34 In this milieu, use of animal models in drug discovery and inflammation research is mainstay.…”

Section: Discussionmentioning

confidence: 99%

“…As the inflammatory basis of disease becomes clear, anti-inflammatory food and food products become of greater interest. [33][34] The research opportunities in nutrition to explore the relationship between a food and food components for an improved state of health and well-being or reduction of disease present the greatest challenge to scientists now and in the future. 35 A lot of researches have documented that extracts from medicinal plants, fruits and vegetables contain such type of phytoconstit-…”

Section: Discussionmentioning

confidence: 99%

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Peels of Citrus Fruits: A Potential Source of Anti-inflammatory and Anti-nociceptive Agents

Malleshappa¹,

Kumaran²,

Krishna³

et al. 2018

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Introduction: The present study was contemplated to evaluate the anti-inflammatory and analgesic potentials in peels of some commercially grown Citrus fruits of South India viz, Lime (Citrus aurantifolia), Orange (Citrus reticulata), Sour Orange (Citrus aurantium), Pomello (Citrus grandis) and Citron (Citrus medica). Methods: The peel of the fruits were separated and subjected to cold extraction using 70% alcohol. The extracts obtained were screened for the presence of phytoconstituents by qualitative phytochemical analysis; the anti-inflammatory activity of extracts at 250 and 500mg/Kg body weight concentrations were assessed by in vivo Carrageenan induced rat paw edema model and in vitro HRBC membrane stabilization assay whereas Tail immersion and Hot plate methods have been used to evaluate their analgesic property. Results: The results revealed that, all extracts treated animals have shown significant decrease in paw edema volume at 3 rd and 4 th hour of treatment and increase in reaction time in tail immersion and hot plate readings at 120 and 150 min and are comparable to the standards. From the results it was evident that Citron peel extract exhibited significant antiinflammatory and analgesic property in all models. Preliminary phytochemical investigation revealed that extracts were bestowed with presence of flavonoids, terpenoids, steroids, glycosides, alkaloids, carotenoids and phenolic compounds which might be responsible for the antinociceptive and anti-inflammatory activities. Conclusion: From the results it was evident that all citrus fruits have prominent activity in terms of parameters assessed in a dose dependent manner and are more effective in the later phase. The study thus documents that Citrus peels are good sources of anti-inflammatory and anti-nociceptive agents.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Peels of Citrus Fruits: A Potential Source of Anti-inflammatory and Anti-nociceptive Agents

Malleshappa¹,

Kumaran²,

Krishna³

et al. 2018

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show abstract

“…At day 15, single-cell suspensions of murine splenocytes were obtained in Roswell Park Memorial Institute (RPMI) media containing 10% foetal bovine serum (FBS) purchased from Gibco Life Technologies (NY, USA) and 1% antibiotics (Gibco Life Technologies, NY, USA), as previously described (Herath et al. 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

Herath

Cho

Kim

et al. 2021

Pharmaceutical Biology

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Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications: a review

et al. 2017

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Anti-inflammatory activities of Dangyuja (Citrus grandis Osbeck) in concanavalin A stimulated murine splenocytes and 12-O-tetradecanoylphorbol-13-acetate-induced murine skin edema

Cited by 11 publications

References 35 publications

Peels of Citrus Fruits: A Potential Source of Anti-inflammatory and Anti-nociceptive Agents

Peels of Citrus Fruits: A Potential Source of Anti-inflammatory and Anti-nociceptive Agents

Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization

Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications: a review

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