Anti-inflammatory activities of ethanol leaves extract and solvent fractions of Zehneria scabra (Cucurbitaceae) in rodents

Belay, Rediet; Makonnen, Eyasu

doi:10.13057/biofar/f180105

Cited by 6 publications

(15 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Haregresa is a popular folk medicine in Ethiopia for the management of febrile illnesses, inflammation, headache, and malaise [46][47][48][49]. Hence, further biomedical screening of its properties against COVID-19 may be considered.…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants and functional foods sold by market vendors and used by their clients for COVID-19 in Gondar City, Ethiopia

Tebaber Chanie Workneh,

Helmut Kloos,

Abyot Endale Gurmu

et al. 2024

World J. Adv. Pharm. Med. Res.

View full text Add to dashboard Cite

Background: Many Ethiopians use traditional medicines. However, little is known about the role of open markets as sources of alternative medicines in preventing and treating COVID-19. Objectives. The objectives of this study are to identify medicinal plants and plant products sold by vendors in the markets of Gondar City and used by their clients to treat the COVID-19-related symptoms of fever, cough, and headache. Methods and Materials: Questionnaires were used to interview vendors and clients. Results: The research identified 38 vendors who sold traditional medicines and 37 clients who reported using medicines for fever, cough, and headache. Of the 14 medicinal, food, and spice plants and plant products sold, the most common were garlic (Allium sativum) followed by black cumin (Nigella sativa) seeds, haregresa (Zehneria scabra) leaves, and basil (Ocimum trifolium) leaves. The plant materials most commonly used were haregresa leaves, garlic, and flax seeds. Four of the plants have active anti-coronavirus, immune-modulatory, and anti-inflammatory compounds. The sale and use of medicinal plants and functional foods reflects traditional cultural practices in Ethiopia. Conclusion: Open-air markets are a major source of indigenous foods and medicines that may be valuable in the management of COVID-19. Medicinal plant products sold for fever, headache, and cough in Gondar City may have mostly palliative and immuno-modulatory benefits. Several areas needing further study are identified.

show abstract

Section: Discussionmentioning

confidence: 99%

Medicinal plants and functional foods sold by market vendors and used by their clients for COVID-19 in Gondar City, Ethiopia

Tebaber Chanie Workneh,

Helmut Kloos,

Abyot Endale Gurmu

et al. 2024

World J. Adv. Pharm. Med. Res.

View full text Add to dashboard Cite

show abstract

“…The method mentioned by Mengie et al and Belay [ 42 , 58 ] was used with a minor change to evaluate the effect of fractions of fruits of A . mexicana on acute inflammation.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. The solvent fractions of the fruits of Argemone mexicana L. (Papaveraceae) have not yet been explored scientifically for in vivo wound healing and anti-inflammatory activities. The objective of this study was, therefore, to evaluate in vivo wound healing and anti-inflammatory activities of the solvent fractions of the fruit of Argemone mexicana L. (Papaveraceae) in rats. Method. The crude extract of Argemone mexicana was fractionated with n-hexane, ethyl acetate, and distilled water. Wound healing activity was evaluated using excision and incision wound models while anti-inflammatory activity was evaluated using carrageenan-induced rat paw and cotton pellet-induced granuloma models. The fractions were evaluated at 5 and 10% ointments using moist-exposed burn ointment as the standard drug, and 100, 200, and 400 mg/kg test doses using aspirin, and dexamethasone as standard drugs for wound healing and anti-inflammatory activities, respectively. All treatment administrations were made orally for anti-inflammatory activity and applied topically for wound healing activity. Result. The 10% w/w ethyl acetate fraction ointment showed a significant percentage of wound contraction, reduced period of epithelialization, increased amount of fibrosis, neovascularization, and collagen tissue formation ( p < 0.01 ). The ethyl acetate fraction also showed a significant increase in tensile strength (55%; p < 0.01 ) and (81.10%; p < 0.01 ) at the tested doses of 5 and 10% w/w ointments, which was comparable to moist-exposed burn ointment. The ethyl acetate fraction also revealed a significant percent edema inhibition (61.41%; p < 0.01 ), suppression of the exudate (38.09% p < 0.01 ), and granuloma mass formations (53.47% p < 0.01 ) at the tested dose of 400 mg/kg. Conclusion. The results of this study showed that the Ethyl acetate fraction of Argemone mexicana fruit has significant wound healing and anti-inflammatory activities which support the traditional claims of the experimental plant.

show abstract

“…Rats were sacrificed via cervical dislocation at the end of the experiment. 12,23 Acute Oral Toxicity Test Based on the limit test requirements of OECD/OCDE Guideline 425, an acute oral toxicity test was conducted. 21 Prior to giving a dose of the extract containing 2000 mg/kg to single, nulliparous, and non-gestational female rats, they were fasted for four hours.…”

Section: Grouping and Dosing Of Animalsmentioning

confidence: 99%

“…To ensure it could always be immersed to the same depth in the measuring chamber of the plethysmometer. 23 The extracts were administered to each study group one hour before formalin injection on the 1st and 3rd days and administered for 7 consecutive days once daily. Carrageenan in 0.1 mL of 1% sodium chloride solution was injected into the right hind paw's plantar side.…”

Section: Carrageenan-induced Paw Edemamentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Anti-Inflammatory Activity of the Methanol Extracts of Premna schimperi Engl (Lamiaceae) Leaves in Rats

Arega,

Nardos,

Debella

et al. 2023

JEP

View full text Add to dashboard Cite

Background: Even though it is a protective reaction, inflammation continues to be one of the most challenging medical disorders. The current conventional anti-inflammatory drugs have many undesirable health effects and are in need of newer drugs. The purpose of this study was to evaluate the anti-inflammatory effects of an aqueous methanol crude extract of Premna schimperi leaves. Methods: Premna schimperi leaf was extracted with 80% methanol and concentrated; the concentrated extract was used to evaluate the acute toxicity and anti-inflammatory effects. For the acute toxicity study, a single dose of Premna schimperi extract at a dose of 2000 mg/kg was administered and observed for 14 days. Acute, sub-acute, and chronic anti-inflammatory models were employed to evaluate the anti-inflammatory effect of the extract compared to the standard drug. Data were analyzed with SPSS V. 27, and the significance was established with a one-way ANOVA followed by a post hoc Tukey's test. Results: Acute oral toxicity testing at a dose of 2000 mg/kg did not show any sign of toxicity. According to the phytochemical study, the plants contained flavonoids, terpenoids, tannins, cardiac glycosides, steroids, phenolics, and anthraquinones. The extract doses of 200 mg/kg, 400 mg/kg, and 800 mg/kg of extracts effectively (p<0.001) reduced paw edema in the acute and sub-acute models of inflammation. When compared to the negative control group, all tested doses in the chronic model significantly (p<0.05) decreased the production of exudates and the amount of granuloma tissue. Conclusion: Premna schimperi displayed significant anti-inflammatory activity. The tested doses inhibit the formation of edema, granulomas, and exudates.

show abstract

Anti-inflammatory activities of ethanol leaves extract and solvent fractions of Zehneria scabra (Cucurbitaceae) in rodents

Cited by 6 publications

References 60 publications

Medicinal plants and functional foods sold by market vendors and used by their clients for COVID-19 in Gondar City, Ethiopia

Medicinal plants and functional foods sold by market vendors and used by their clients for COVID-19 in Gondar City, Ethiopia

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Evaluation of Anti-Inflammatory Activity of the Methanol Extracts of Premna schimperi Engl (Lamiaceae) Leaves in Rats

Contact Info

Product

Resources

About