Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: Experimental and computational studies

Khan, Inamullah; Nisar, Muhammad; Ebad, Farooq; Nadeem, Said; Saeed, Muhammad; Khan, Haroon; Samiullah, -; Khuda, Fazli; Karim, Nasiara; Ahmad, Zia

doi:10.1016/j.jep.2008.10.009

Cited by 126 publications

(99 citation statements)

References 16 publications

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“…Thus, the hypotonicity and heat-induced RBC membrane lysis potential exhibit upon treatment with plant extracts are considered as significant indicators to confirm the extracts as anti-inflammatory effects [41,42]. According to the previous studies (in vivo and in vitro), flavonoids were found to possess membrane stabilizing potential on lysosomal membrane [43]. In addition, tannins and saponins-rich plant extracts show the stabilizing activity over erythrocyte member due to the binding capability of those compounds to cations and other biomolecules of the membrane surface [44].…”

Section: Membrane Stabilizing Activitymentioning

confidence: 99%

Potentiality of Crataeva nurvala bark in the management of thrombosis and membrane stabilization in the rural area, Bangladesh.

Uddin¹,

Laboni²,

Karim³

et al. 2018

Appl Med Res

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Aim: Crataeva nurvala (C. nurvala) is a medicinally active plant, potentially used as traditional means of treating many health ailments such as prostatitis, prostate enlargement, inflammatory conditions, heart disease, thyroid and endocrine disorder, and urinary tract infection, respectively, in the rural region of Tangail, Jamalpur, Sherpur, and Barishal district since primitive era. In our concurrent research, the bark of this plant was undertaken in order to justify its folkloric history of thrombolytic, membrane stabilizing activity in vitro model, and for the quantification of total phenol content. Methods: The concentrated methanol extract partitioned into different fractions showed different amount of yield like 18.2 g of petroleum ether, 13 g of carbon tetrachloride, 11.1 g of chloroform, and 9.9 g of aqueous, respectively, then all of the fractioned extracts were employed to investigate folkloric uses of thrombolytic and membrane stabilizing potential in vitro models. Results: In the extrapolation of thrombolytic assay, petroleum ether fractioned exhibit the highest percent of clot lysis (27.36% ± 0.10%) activity compared with other fractioned and extract. Crude methanolic extract profoundly inhibited the breakdown of erythrocytes membrane (65.79% ± 0.40%)-induced by hypnotic solution and heat. On the other hand, acetylsalicylic acid (reference standard) resulted in 83.147% ± 0.39% inhibition of clot lysis. Alternatively, aqueous soluble fraction exposed slightly higher level of membrane stabilizing activity provoked by heat-induced hemolysis (75.3 ± 0.39). Conclusions:The present study was investigated to confirm the medicinal value of C. nurvala bark as a thrombolytic and membrane stabilizing agent. ARTICLE HISTORY

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Section: Membrane Stabilizing Activitymentioning

confidence: 99%

Potentiality of Crataeva nurvala bark in the management of thrombosis and membrane stabilization in the rural area, Bangladesh.

Uddin¹,

Laboni²,

Karim³

et al. 2018

Appl Med Res

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“…Subcutaneous injection of Brewer's yeast induces pyrexia by increasing the synthesis of prostaglandin. It is considered as a useful test for the screening of plants materials as well as synthetic drugs for their antipyretic effect [29,30]. Yeast induced pyrexia is called pathogenic fever and its etiology could be the production of prostaglandins [31].…”

Section: Groupmentioning

confidence: 99%

Anti-pyretic, Anti-inflammatory and Analgesic Activities of Aqueous Leaf Extract of Urtica Dioica (L.) in Albino Mice

Safari¹,

Ngugi²,

Orinda³

et al. 2016

Med Aromat Plants

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“…Shu et al 2006 has studied the anti inflammatory activity 18 . Sieboldogenin, isolated from ethyl acetate fraction of Smilax china has potent anti-inflammatory activity 19 . In Traditional Chinese Medicine, it is used in the management of chronic pelvic inflammatory disease 18 , syphilis, acute bacterial dysentery and chronic nephritis 20 .…”

Section: Smilax Chinamentioning

confidence: 99%

Therapeutic Potency of a Siddha Formulation Kandhaga Rasayanam: A Review

Meena¹,

Rs²

2015

Int.J. Res. Ayurveda Pharm.

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Siddha system of medicine is one of the oldest systems of medicine practised among Tamil speaking community. The medicines in this system are prepared from raw materials like herbs, minerals/metals and animal products. Kandhaga Rasayanam is a herbo mineral formulation with 16 ingredients. It is used for treating skin diseases, arthritis, leucorrhoea, urinary diseases etc. This review is aimed to bring out scientific evidence for the therapeutic usage of Kandhaga Rasayanam and focussed on the pharmacological activity responsible for the curative nature of the drug. Most of its drugs have antimicrobial, anti-inflammatory activity hence justifying its usage in above mentioned diseases.

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Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: Experimental and computational studies

Cited by 126 publications

References 16 publications

Potentiality of Crataeva nurvala bark in the management of thrombosis and membrane stabilization in the rural area, Bangladesh.

Potentiality of Crataeva nurvala bark in the management of thrombosis and membrane stabilization in the rural area, Bangladesh.

Anti-pyretic, Anti-inflammatory and Analgesic Activities of Aqueous Leaf Extract of Urtica Dioica (L.) in Albino Mice

Therapeutic Potency of a Siddha Formulation Kandhaga Rasayanam: A Review

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