Anti-inflammatory activity and lipid peroxidation inhibition of iridoid lamiide isolated from Bouchea fluminensis (Vell.) Mold. (Verbenaceae)

Delaporte, Rosemeres Horwat; Sánchez, Gregorio Martı́nez; Cuéllar, Armando Cuéllar; Giuliani, Attilia; Mello, João Carlos Palazzo de

doi:10.1016/s0378-8741(02)00181-2

Cited by 60 publications

(52 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mold., popularly known as gervão-falso ("false verbena") or gervão-de-folha-grande ("large-leaf verbena"), is a herbaceous plants found in Brazil and Bolivia (Troncoso 1974;Pupo et al 2008a). The plant is used in traditional medicine for its properties of stimulating and regulating the digestive system (Delaporte et al 2002), as well as for its anti-inflammatory, antifungal and analgesic effects (Delaporte et al 2001(Delaporte et al , 2002Costa et al 2003;Falcão et al 2005;Fenner et al 2006;Pupo et al 2008aPupo et al , 2008b. Chemical studies of B. fluminensis have isolated the organic compounds responsible for the pharmacological effects of the species (von Poser et al 1997;Schuquel et al 1998;Delaporte et al 2002).…”

Section: Introductionmentioning

confidence: 99%

An efficient system for in vitro propagation of Bouchea fluminensis (Vell.) Mold. (Verbenaceae)

et al. 2014

View full text Add to dashboard Cite

This study aimed to establish and propagate in vitro plants of Bouchea fluminensis, a medicinal species known in Brazil as gervão-falso ("false verbena"), evaluating the influences of different growth regulators on in vitro multiplication and rooting stages, as well as examining ex vitro acclimatization of rooted plants. Explants were established on Murashige and Skoog medium at half strength of salts and vitamins without growth regulators. For multiplication, the explants were subjected to combinations of 6-benzyladenine (BA; 0, 2.5, 5.0 and 7.5 μM) and α-naphthalene-acetic acid (NAA; 0, 0.2, 0.4 and 0.6 μM). The medium found to induce the greatest number of shoot was that containing 5 μM of BA (NAA-free). For rooting, we evaluated three auxins (NAA, indole-3-acetic acid and indole-3-butyric acid; 0.1, 0.2, 0.3 and 0.4 μM), as well as a control. No differences were observed between the control and the other treatments. The auxin-free medium was deemed the most suitable, because it ensures the lowest cost in the micropropagation procedures. We obtained 100% survival of the acclimatized seedlings, and the plants showed normal vegetative and reproductive development, suggesting that the micropropagation did not alter the biological cycle of this species. The results show the importance and potential of micropropagation for biodiversity conservation of Bouchea fluminensis.

show abstract

Section: Introductionmentioning

confidence: 99%

An efficient system for in vitro propagation of Bouchea fluminensis (Vell.) Mold. (Verbenaceae)

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Free radicals propagate inflammation by causing release of inflammatory cytokines, such as interleukin-1, tumor necrosis factor-α, and interferon-γ, that stimulate recruitment of additional neutrophils and macrophages. Neutralization of free radicals by antioxidant agents can attenuate inflammation (Delaporte et al 2002). Thus, as eriodictyol exhibited a highly anti-oxidant potential, we believe that it may be responsible at least partly for its anti-inflammatory and immunomodulatory potentials.…”

Section: Discussionmentioning

confidence: 87%

Investigation of immunomodulatory and anti-inflammatory effects of eriodictyol through its cellular anti-oxidant activity

Mokdad-Bzéouich

Mustapha

Sassi

et al. 2016

Cell Stress and Chaperones

View full text Add to dashboard Cite

Many studies have been performed to assess the potential utility of natural products as immunomodulatory agents to enhance host responses against infection or to ameliorate immune-based pathologies. To determine whether eriodictyol has immunomodulatory effects and clarify which types of immune effector cells are stimulated in vitro, we investigated the stimulatory effect of eriodictyol on spleen cells isolated from BALB/c mice. Eriodictyol significantly stimulated splenocyte proliferation. However, only B lymphocytes (not T lymphocytes) could be stimulated by eriodictyol in a dose-related manner. Studies assessing potential effect of eriodictyol on innate immunity reported that eriodictyol enhanced significantly the killing activity of natural killer (NK) cells, T lymphocytes, and macrophages. We also demonstrated that eriodictyol inhibited nitric oxide (NO) production and lysosomal enzyme activity in murine peritoneal macrophages cultured ex-vivo, suggesting a potential anti-inflammatory effect in situ. Eriodictyol revealed also a cellular anti-oxidant activity in splenocytes and macrophages. Furthermore, eriodictyol increased catalase activity in spleen cells. From this data, it can be concluded that eriodictyol exhibited an immunomodulatory effect that could be ascribed in part to a cytoprotective effect related to its anti-oxidant activity.

show abstract

“…However, free radicals are the main mediators promoting the inflammatory process. By neutralizing free radicals, antioxidants can reduce inflammation (Delaporte et al, 2002;Geronikaki and Gavalas, 2006). Therefore, we urge biologists to focus on the mechanisms of action of bioactive compounds from early tracheophytes (pteridophytes) in medicinal applications.…”

Section: Mechanisms Of Action Of Phytochemicalsmentioning

confidence: 99%

A review of the use of pteridophytes for treating human ailments

Xavier-ravi

Vigila

Zhang

et al. 2018

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:The aim of this review was to explore the pharmacological activity of early tracheophytes (pteridophytes) as an alternative medicine for treating human ailments. As the first vascular plants, pteridophytes (aka, ferns and fern allies) are an ancient lineage, and human beings have been exploring and using taxa from this lineage for over 2000 years because of their beneficial properties. We have documented the medicinal uses of pteridophytes belonging to thirty different families. The lycophyte Selaginella sp. was shown in earlier studies to have multiple pharmacological activity, such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, antiviral, antimicrobial, and anti-Alzheimer properties. Among all the pteridophytes examined, taxa from the Pteridaceae, Polypodiaceae, and Adiantaceae exhibited significant medicinal activity. Based on our review, many pteridophytes have properties that could be used in alternative medicine for treatment of various human illnesses. Biotechnological tools can be used to preserve and even improve their bioactive molecules for the preparation of medicines against illness. Even though several studies have reported medicinal uses of ferns, the possible bioactive compounds of several pteridophytes have not been identified. Furthermore, their optimal dosage level and treatment strategies still need to be determined. Finally, the future direction of pteridophyte research is discussed.

show abstract

Anti-inflammatory activity and lipid peroxidation inhibition of iridoid lamiide isolated from Bouchea fluminensis (Vell.) Mold. (Verbenaceae)

Cited by 60 publications

References 15 publications

An efficient system for in vitro propagation of Bouchea fluminensis (Vell.) Mold. (Verbenaceae)

An efficient system for in vitro propagation of Bouchea fluminensis (Vell.) Mold. (Verbenaceae)

Investigation of immunomodulatory and anti-inflammatory effects of eriodictyol through its cellular anti-oxidant activity

A review of the use of pteridophytes for treating human ailments

Contact Info

Product

Resources

About