Anti-inflammatory activity and toxicity of the water extract of Terminalia chebula rezt in rats

Sireeratawong, Seewaboon; Jaijoy, Kanjana; Panunto, Watcharin; Soonthornchareonnon, Noppamas

doi:10.1055/s-0032-1320799

Cited by 5 publications

(4 citation statements)

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“…In our study, Altan Arur 5 showed no toxic effects in mice and rats. Several studies on T. chebula have reported no toxic effects in rats and mice at doses of ≥ 5,000 kg; however, those studies could not determine the LD50 because the animals did not die even after oral administration of Altan Arur 5 at > 5,000 mg/kg body weight [20][21][22][23][24][25]. These findings indicate that T. chebula has no toxic effects on animals such as mice and rats.…”

Section: Discussionmentioning

confidence: 83%

The Chronic and Acute Toxicity of Traditional Medicines Containing Terminalia chebula

ARONGQIQIGE

Enebish

Song³

et al. 2023

J Pharmacopuncture

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Objectives: Terminalia chebula, the main ingredient of Altan Arur 5, has been used for many years in traditional medicine. This medicine is more effective than other drugs and is used to treat chronic gastritis and gastrointestinal disorders such as peptic ulcers and esophageal reflux. Other ingredients of Altan Arur 5 are Punica granatum (pomegranate), tulip seeds, black balm, and excreta of Trogopterus xanthipes. The main ingredients of T. chebula are antibacterial and analgesic in traditional medicine. Despite having been used for many years and although many studies have been conducted on the beneficial effects of this medicine and its ingredients, the toxicity of Altan Arur 5 has not yet been elucidated. Therefore, we aimed to study the toxicity of Altan Arur 5 to ensure that it is safe to use. Methods: Acute and chronic toxicity of Altan Arur 5 were assessed in 10 Kunming mice and 8 Sprague-Dawley rats, respectively, in different doses. In the acute toxicity study, Altan Arur 5 was orally administered to Kunming mice in doses of 12 g/kg, 24 g/kg, and 48 g/kg for 14 days. In the chronic toxicity study, it was orally administered to Sprague-Dawley rats in doses of 1.25 g/kg, 2.5 g/kg, and 5 g/kg for 12 weeks. Results: No significant differences were observed in the relative organ weights for mice treated with Altan Arur 5 compared with those in the control group. Furthermore, no macro-or microstructural changes were noted in the organs of any group. Conclusion: Our toxicity testing revealed that the traditional medicine Altan Arur 5 has no toxic effects in vivo.

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Section: Discussionmentioning

confidence: 83%

The Chronic and Acute Toxicity of Traditional Medicines Containing Terminalia chebula

ARONGQIQIGE

Enebish

Song³

et al. 2023

J Pharmacopuncture

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“…The fruits of TC have been widely used in many Asian countries as a traditional folk medicine for treating cough or diarrhea. The TC bioactive constituents include the polyphenols chebulagic acid, chebulinic acid, chebulanin and gallic acid [ 17 ], which have anti-oxidant [ 12 ], anti-inflammatory [ 13 , 14 ], anti-bacterial [ 15 ] and anti-arthritic properties [ 16 ]. Previously, we demonstrated the in vitro anti-oxidative and anti-inflammatory properties of the chebulanin polyphenol.…”

Section: Discussionmentioning

confidence: 99%

“…Terminalia chebula retzius (TC) is a traditional folk medicine that has been widely used in Asian countries for its anti-oxidant [ 12 ], anti-inflammatory [ 13 , 14 ], anti-bacterial [ 15 ] and anti-arthritic [ 16 , 17 ] properties. Three polyphenolic compounds have been isolated from the fruits of TC : chebulagic acid, chebulanin, and chebulinic acid [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Arthritic Effect of Chebulanin on Collagen-Induced Arthritis in Mice

Zhao

Liu

et al. 2015

PLoS ONE

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Rheumatoid arthritis is a chronic degenerative autoimmune disease characterized by persistent inflammation of synovial membranes, which leads to cartilage destruction and bone erosion. To date, there are no effective therapies to slow the progress of this degenerative condition. Here, we evaluate the anti-arthritic effect of chebulanin, an abundant anti-inflammatory agent isolated from Terminalia chebula, in collagen induced arthritis in DBA/1 mice by intragastric administration. Arthritic severity was scored by performing histopathological evaluation of the joints and measuring the expression of inflammatory cytokines and relative enzymes by immunohistochemical staining. In parallel, bone destruction and erosion were confirmed by micro-CT. Our data revealed that chebulanin significantly improved the severity of arthritis. Specifically, the histopathological characteristics of the tissues were improved and expression of TNF-α, IL-6, MMP-3 and COX-2 in the paws and joints of the treated mice decreased in a dose-dependent manner compared with control mice. Furthermore, micro-CT analysis revealed that chebulanin induced a dose-dependent reduction in cartilage destruction and bone erosion. Taken together, our findings suggest that chebulanin suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice. Therefore, chebulanin is a strong therapeutic alternative for the treatment of RA.

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“…[11] Oral administrations of TFWE at 5,000 mg/kg body weight single dose or 1,200 mg/kg body weight continuously dose for 270 days did not produce signs of toxicity in rats. [12,13] These experimental evidence suggest that TFWE could be a potential antidiabetic agent. However, the essentially clinical data of TFWE to prevent T2D progression has not been established.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Assessment of Glycemic Control and Body Fat Reduction Effects of Terminalia chebula Retz. Extract on Pre-diabetic Subjects

Sombattera¹,

Sungthong²,

Rinthong³

2021

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Background: Terminalia chebula Retz. (Combretaceae) is a medicinal herb using in traditional medicine worldwide and has hypoglycemic effects in animal models. Objectives: The present study was a double-blind, placebo-controlled trial designed to study the effect of T. chebula fruit water extract (TFWE) in pre-diabetic subjects. The efficacy of TFWE and placebo were compared in terms of reducing fasting blood sugar (FBS) levels, body mass indexes (BMI), body circumferences and skinfold thicknesses. Adverse events of TFWE intervention were also investigated. Materials and Methods: TFWE was phytochemically quantitated by HPLC analysis and its inhibitory action on alpha-glucosidase. In a clinical study, 80 pre-diabetic healthy subjects were classified according to BMI as normal weight and overweight and each group was further divided into 2 groups. The treatment group received 2 capsules of TFWE 500 mg, 2 times per day, before meals for 8 weeks and the control group received 2 placebo capsules, taken orally as the treatment group. Data was collected at week 0, 4 and 8 of the study. Results: For overweight participants receiving TFWE, the mean FBS levels were significantly lower than that of the placebo group (p = 0.026) at week 8. Visceral fat levels also showed a significant reduction (p = 0.039) compared to the placebo group. TFWE dispensation did not show serious adverse events. Conclusion: The administration of 2,000 mg TFWE per day was considered safe for the pre-diabetic healthy subjects with benefits in obesity management.

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Anti-inflammatory activity and toxicity of the water extract of Terminalia chebula rezt in rats

Cited by 5 publications

References 0 publications

The Chronic and Acute Toxicity of Traditional Medicines Containing Terminalia chebula

The Chronic and Acute Toxicity of Traditional Medicines Containing Terminalia chebula

Anti-Arthritic Effect of Chebulanin on Collagen-Induced Arthritis in Mice

Preliminary Assessment of Glycemic Control and Body Fat Reduction Effects of Terminalia chebula Retz. Extract on Pre-diabetic Subjects

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