Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats

Abstract

Introduction Kaempferia galanga L. ( K. galanga ; local name kencur , Zingiberaceae) is a plant commonly used as a kitchen spice, and empirically it is often used for medicinal purposes. This plant has been shown to have an anti-inflammatory role, but no research has been found on its effect on oral mucosal ulcer. This study aimed to investigate anti-inflammatory activity and wound healing effect of the ethanol extract of K. galanga L. rhizome (EEKG) on the chemical-induced oral mucosal ulcer in Wistar rats. Methods In this study, 35 rats were divided into 7 groups (normal, negative, triamcinolone acetonide, and 4 EEKG groups). Acetic acid 70% was used as the oral mucosal ulcer inducer. Parameters observed were macroscopic and microscopic histopathological examinations. Results The results revealed that dose of 0.5% of the EEKG was effective in increasing the percent recovery of ulcer area and inflammation sign scores. Meanwhile, doses of 0.5–2% of EEKG were effective in reducing the histopathological score. Interestingly, topical EEKG in our study was more effective compared with triamcinolone acetonide (the conventional therapy for oral mucosal ulceration). Discussion The EEKG has been confirmed its anti-inflammatory activity by accelerating the healing process on the chemical-induced oral mucosal ulcer in Wistar rats, based on the percent recovery of the ulcer area, the percent recovery of the inflammation sign score, and the histopathology score. Conclusion Taken together, K. galanga L. is very potential to be developed as a prospective phytopharmaceutical for the treatment of oral mucosal ulceration in human after clinical trials.

Analysis of antidiabetic, antiulcer and analgesic potential of traditional ethnomedicinal plant Emex spinosa (L.) Campd. from Azad Jammu and Kashmir

“…The aim of this portion of the experiment was to determine the weight of the mucosa layer that prevents lesions from developing. In this protocol procedure of Wahyuni et al, (2022) was followed [ 43 ]. During the stomach dissection, the contents were taken and placed in centrifuge tubes, which were centrifuged for 10 minutes at 1000 rpm.…”

The industrially important genus Kaempferia: An ethnopharmacological review

“…Furthermore, KG has the potential to evolve into a phytopharmaceutical against oral mucosal ulcers in people as revealed in an investigation after receiving clinical approval. It is mandatory to run clinical investigations prior to certifying the usage of any such medical formulation (Wahyuni et al, 2022).…”

Acute Toxicity of Ethyl Acetate Fraction of Kaempferia galanga L. Rhizome

“…By lowering the formation of Leukotriene B, an inflammatory mediator, KG has numerous anti-inflammatory actions [2]. Compared to triamcinolone acetonide, a traditional therapeutic therapy for oral mucosal ulcers, it accelerates the wound healing 1242 (2023) 012007 IOP Publishing doi:10.1088/1755-1315/1242/1/012007 2 process of ulcers on the oral mucosa of rats caused by 70% acetic acid, producing a more successful wound healing process [3]. According to Ranjan Dash et al [4], KG shows antibacterial action against gram-positive and gram-negative bacteria [4].…”