Anti-inflammatory activity of Aloe vera against a spectrum of irritants

Rm, Davis; Leitner, MG; Russo, JM; Byrne, Mary

doi:10.7547/87507315-79-6-263

Cited by 65 publications

(32 citation statements)

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“…It has been shown that in experimental animals Aloe vera reduces inflammation detected as reduced neutrophil migration and edema formation (Davis et al, 1989). In Helicobacter pylori-infected rats Aloe vera significantly reduced leukocyte adhesion and TNF␣ levels (Prabjone et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Budai

Varga

Milesz³

et al. 2013

Molecular Immunology

154

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a b s t r a c tAloe vera has been used in traditional herbal medicine as an immunomodulatory agent inducing antiinflammatory effects. However, its role on the IL-1␤ inflammatory cytokine production has not been studied. IL-1␤ production is strictly regulated both at transcriptional and posttranslational levels through the activity of Nlrp3 inflammasome. In this study we aimed to determine the effect of Aloe vera on the molecular mechanisms of Nlrp3 inflammasome-mediated IL-1␤ production in LPS-activated human THP-1 cells and monocyte-derived macrophages. Our results show that Aloe vera significantly reduced IL-8, TNF␣, IL-6 and IL-1␤ cytokine production in a dose dependent manner. The inhibitory effect was substantially more pronounced in the primary cells. We found that Aloe vera inhibited the expression of pro-IL-1␤, Nlrp3, caspase-1 as well as that of the P2X7 receptor in the LPS-induced primary macrophages. Furthermore, LPS-induced activation of signaling pathways like NF-B, p38, JNK and ERK were inhibited by Aloe vera in these cells.Altogether, we show for the first time that Aloe vera-mediated strong reduction of IL-1␤ appears to be the consequence of the reduced expression of both pro-IL-1␤ as well as Nlrp3 inflammasome components via suppressing specific signal transduction pathways. Furthermore, we show that the expression of the ATP sensor P2X7 receptor is also downregulated by Aloe vera that could also contribute to the attenuated IL-1␤ cytokine secretion. These results may provide a new therapeutic approach to regulate inflammasome-mediated responses.

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Section: Introductionmentioning

confidence: 99%

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Budai

Varga

Milesz³

et al. 2013

Molecular Immunology

154

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“…It improved healing by increasing the blood supply, which increased oxygenation as a result [13]. Davis et al, in his study examined the possibility of aloe gel being an active growth substance as mannose-6-phosphate was the major sugar in aloe gel [14].…”

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confidence: 99%

Aloe Vera in Dentistry

Sujatha

Gs²,

Muruganandan

et al. 2014

JCDR

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“…Moreover, the healing powers of AV through high-molecular-weight polypeptide constituent from the gel demonstrated a healing effect on excisional wounds in rats. [15] Yagi et al [16] reported that AV gel contains a glycoprotein with cell proliferating-promoting activity, while Davis et al [17] noted that AV increasing blood supply, which increased oxygenation as result. [18] As regarded to erythema score among study groups at different times, decreased in both types of AV.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Aloe vera Gel in Treatment of Oral Lichen Planus

Ahmed¹,

Gadalla²,

Elmeadawy³

et al. 2018

IDJAR

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Background: Aloe vera (AV) gels with different concentrations are available in the market. In this study, we evaluate the efficacy of AV gel with two different concentrations in the treatment of oral lichen planus (OLP) compared with placebo. Materials and Methods: A total of 21 females suffering from the clinical signs and symptoms of OLP were grouped into Group (I) patients receiving AV gel divided into two subgroups, subgroup (A) received AV 70% concentration (7 patients) and subgroup)B) received AV 90% concentration (7 patients) and Group (II) control group received placebo (7 patients).Results: There was no statistically significant difference between ulcer sizes at all points of follow-up in Egyptian and Australian AV compared to placebo. The degree of change was higher in Egyptian than Australian AV regarding size, erythema, reticulation, and total area of lesion. However, there was no statistically significant difference between two types of treatment as regards all measured parameters (P > 0.05). Conclusions: AV gel whether Egyptian or Australian is statistically significantly more effective than placebo in inducing marked improvement clinically of OLP. Therefore, AV gel can be considered a safe alternative treatment for patients with OLP. Clinical Significance: AV gel can be considered a safe alternative treatment for patients with OLP.

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Anti-inflammatory activity of Aloe vera against a spectrum of irritants

Cited by 65 publications

References 0 publications

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Aloe Vera in Dentistry

The Efficacy of Aloe vera Gel in Treatment of Oral Lichen Planus

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