Anti-inflammatory Activity of Andong Leaf Extract (Cordyline Terminalis Kunth) Against Edema in the Soles of Wistar Rats

Abstract

The Balinese plant andong (Cordyline terminalis Kunth) has anti-inflammatory properties. The focus of this research was to determine whether andong leaf extract has anti-inflammatory properties and is effective against carrageenan-induced edema in rat soles. In this study, carrageenan was used to induce inflammation in the soles of Wistar rats. 25 rats were divided into five treatment groups. Group I was given aquadest as the control; group II was given diclofenac sodium at a dose of 4.5 mg/kgbw as a drug control; and groups III, IV and V were given ethanol extract of andong leaves at doses of 150 mg/kgbw, 300 mg/kgbw, and 600 mg/kgbw orally as test groups. For six hours, the inflammation volume was measured using a plethymometer. One-way ANOVA was used to test differences between the treatment groups. The results showed that the ethanol extract of andong leaves had the highest anti-inflammatory activity in the six-hour period when given at doses of 150 mg/kgbw (36.35% 0.02), 300 mg/kgbw (26.30% 0.20), and 600 mg/kgbw (20.67% 0.16) with a significant difference (p < 0.05) compared to the negative control (86.84% 0.092), but this was not significantly different from the positive control (22.21% 0.01). Based on these findings, it can be concluded that a dose of 600 mg/kgbw is the most effective in reducing inflammation.
 Keywords: Anti-inflammatory, Red andong leaf, Carrageenan, Wistar rat, Edema

Ethnobotany, Phytochemistry, and Biological Activities of the Genus Cordyline

“…The methanol extract of the rhizomes of C. fruticosa has been investigated for its hypolipidemic potential in Wistar rats. Intake of 30 mg/Kg and 70 mg/Kg was found to lower lipid plasma levels in mice [78]. This extract showed the potential to lower blood fatty acid, glucose, and triglyceride levels in obese Wistar rats [79].…”

“…Intake of 30 mg/Kg and 70 mg/Kg was found to lower lipid plasma levels in mice [78]. This extract showed the potential to lower blood fatty acid, glucose, and triglyceride levels in obese Wistar rats [79]. The n-butanolsoluble fraction of the methanol extract of senescent leaves of C. australis was assessed for its antiparasitic activity; it displayed a weak inhibition against Plasmodium falciparum, Tripanosoma brucei, and Tripanosoma cruzi, with an IC 50 of 12, 23 and 32 µM, respectively, relative to 0.018 µM of Chloroquine [10].…”