Anti-inflammatory activity of (−)-aptosimon isolated from Daphne genkwa in RAW264.7 cells

Efficacy of Daphne oleoides subsp. kurdica used for wound healing: Identification of active compounds through bioassay guided isolation technique

“…oleoides, Daphne genkwa, Daphne pontica, Daphne retusa, Daphne gnidium and Daphne odora have anti-inflammatory activities (Craker and Simon, 1987;Sakuma et al, 1998;Yesilada et al, 2001;Kupeli et al, 2007;Lee et al, 2009). Daphnetin (1) was previously isolated from the roots of Daphne oleoides subsp.…”

“…Various biological activities were also reported for Daphne species including analgesic, anti-inflammatory, antioxidant, anticancerogenic, antimicrobial, anti-ulcerogenic, abortive, hypocholesterolemic and hemostatic (Murakami et al, 1992;Cottiglia et al, 2001;Hong et al, 2002;Deiana et al, 2003;Kupeli et al, 2007;Zhang et al, 2007;Zheng et al, 2007;Lee et al, 2009).…”

Evaluation of subchronic (13week) toxicity and genotoxicity potential of vinegar-processed Genkwa Flos

“…The flavonoids isolated from GF are known to have remarkable biological activities, such as anti-inflammatory (Lee et al, 2009), analgesic (Wang et al, 2005) and immunoregulatory action . In addition, daphnane diterpenoids isolated from GF possess antitumor (Badawi et al, 1983;Jo et al, 2012), antifertility (Hu et al, 1985), antihyperglycemic (Carney et al, 1999), and antiviral (Allard et al, 2012) properties.…”

Assessment of the embryotoxicity of four Chinese herbal extracts using the embryonic stem cell test

“…It is commonly used as an abortifacient (10), with purgative, diuretic and anti-inflammatory actions (11). Since the enactment of China's one-child family planning policy, studies of Flos Genkwa have focused on its abortion efficacy and mechanisms (12).…”