Anti-inflammatory activity of arctigenin from Forsythiae Fructus

Kang, Hyo Sook; Lee, Ji Yun; Kim, Chang Jong

doi:10.1016/j.jep.2007.11.030

Cited by 128 publications

(70 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A trimethoxylated dibenzylbutyrolactone lignan, arctigenin (4′-Omethylmatairesinol) is another antitumor lignan with selective toxicity against cancer cells under glucose starvation (Awale et al 2006;Kim et al 2010;Sun et al 2011). Arctigenin also has various other biological functions, such as antiproliferative (Matsumoto et al 2006;Ryu et al 1995), hepatoprotective (Kim et al 2003), anti-inflammatory, and analgesic activities (Fan et al 2006;Kang et al 2008). It also suppresses the heat shock response in mammalian cells (Ishihara et al 2006), inhibits mitogen-activated protein kinases (Cho et al 2004) and cyclic AMP phosphodiesterase (Nikaido et al 1981), and has a relaxation effect on histamine-induced contraction of tracheal muscles (Fujimoto et al 1992).…”

mentioning

confidence: 99%

A lignan O-methyltransferase catalyzing the regioselective methylation of matairesinol in Carthamus tinctorius

Umezawa

Ragamustari

Nakatsubo

et al. 2013

Plant Biotechnology

View full text Add to dashboard Cite

Lignans are a group of plant phenolic compounds with various biological activities, including antitumor and antioxidant properties. O-Methylation is a critical step in biosynthesis of these compounds. However, little is known about the O-methyltransferase (OMT) enzymes that catalyze lignan O-methylation. We discovered a highly regioselective OMT activity in safflower (Carthamus tinctorius) seeds that catalyzed the methylation of matairesinol, a dibenzylbutyrolactone lignan, into 4′-O-methylmatairesinol (arctigenin) but not 4-O-methylmatairesinol (isoarctigenin). By examining such OMT activity in correlation with OMT transcript abundances during seed development, we cloned a few putative OMT cDNAs and produced their recombinant proteins in Escherichia coli. Among them, one protein exhibited O-methylation activity for matairesinol with the regioselectivity identical to that of the plant protein, and was named C. tinctorius matairesinol OMT (CtMROMT). CtMROMT did not show any detectable OMT activities towards phenylpropanoid monomers under the reaction conditions tested, while it methylated flavonoid apigenin efficiently into 4′-O-methylapigenin (acacetin). However, quantitative real-time polymerase chain reaction analysis demonstrated that expression of the CtMROMT gene was synchronized with the CtMROMT activity profile and arctigenin accumulation in the plant. These results demonstrated that CtMROMT is a novel plant OMT for lignan methylation.

show abstract

mentioning

confidence: 99%

A lignan O-methyltransferase catalyzing the regioselective methylation of matairesinol in Carthamus tinctorius

Umezawa

Ragamustari

Nakatsubo

et al. 2013

Plant Biotechnology

View full text Add to dashboard Cite

show abstract

“…Edema formation results from the synergistic action of inflammatory mediators such as histamine, serotonin and bradykinin produced under the effect of cycloxygenase-2 (COX-2) at the site of a local inflammatory insult leading to increased vascular permeability and blood flow. 15,16 Edema formation due to egg albumin in the rat paw is a biphasic event; the early phase of edema, which begins immediately after the administration of the irritant and lasting up to 2 h, is probably due to the release of histamine and serotonin. While the latter phase, occurring from 3 to 5 h after the administration of the irritant is induced by bradykinin, protease, prostaglandins and lysosome.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

Akram¹,

Benkiki²,

Eddine³

et al. 2018

View full text Add to dashboard Cite

Objectives:This study was aimed to explore the antipyretic and anti-inflammatory effects of n-butanol etract of Atractylis flava Desf (A. flava) using experimentally induced inflammation and pyrexia models in rats. Methods: In the acute toxicity study, a single oral dose of 2000 mg/kg of n-butanol extract was given to rats. The antipyretic activity was evaluated using brewer's yeast induced pyrexia in rats. In addition, albumin induced rat paw edema was performed by the injection of 100 µL undiluted fresh egg albumin to assess the anti-inflammatory effects of the plant. Results: The results of the present study revealed that n-butanol extract of A. flava significantly (P<0.001) reduced fresh egg albumin-induced rat paw edema and also inhibited fever significantly in brewer's yeast induced pyrexia. Conclusion: The results of the present study indicated that A. flava possesses antipyretic and anti-inflammatory activity in the models studied.

show abstract

“…Apart from A. lappa, AC is found in various plants such as Bardanae fructus, Saussurea medusa, Torreya nucifera and lepomea cairica. AC prevents leukocytes from recruitment into the inflamed tissue [21]. AC blocks TNF-α production by impairments of AP-1 activation [9].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-6 and Cyclooxygenase-2 Downregulation by Fatty-Acid Fractions of Ranunculus Constantinopolitanus

Vemulpad¹,

Jamie²

2014

Recent Advances in Plant-Based, Traditional, and Natural Medicines

View full text Add to dashboard Cite

show abstract

Anti-inflammatory activity of arctigenin from Forsythiae Fructus

Cited by 128 publications

References 36 publications

A lignan O-methyltransferase catalyzing the regioselective methylation of matairesinol in Carthamus tinctorius

A lignan O-methyltransferase catalyzing the regioselective methylation of matairesinol in Carthamus tinctorius

Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

Interleukin-6 and Cyclooxygenase-2 Downregulation by Fatty-Acid Fractions of Ranunculus Constantinopolitanus

Contact Info

Product

Resources

About