Anti-inflammatory activity of Butea monosperma flowers

Shahavi, Vinayaka; Desai, Sandhya K.

doi:10.1016/j.fitote.2007.06.014

Cited by 43 publications

(24 citation statements)

References 8 publications

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“…The methanolic extract of flowers of Butea monosperma inhibited the carrageenan induced paw edema and cotton pellet induced granuloma formation suggesting potent anti inflammatory activity 13 . Butein isolated from BM flowers significantly inhibited COX-2 expression and phosphomitogen activated protein kinase followed by inhibition in total activity of PKC suggesting the anti-inflammatory and anti-cancer activity 30 .…”

Section: Discussionmentioning

confidence: 96%

“…Butea monosperma flowers contain butin and butrin, isobutrin, palasitrin, coreipsin and isocoreipsin, chalcones, and aurones 12 . Methanolic extract of the Butea monosperma exhibited anti-inflammatory and analgesic activity in carrageenin induced paw edema and acetic acid induced writhing test cotton pellet induced granuloma formation 13 . However no compelling evidences are available for its usefulness in treatment of bronchial asthma.…”

Section: Introductionmentioning

confidence: 94%

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Mechanistic Evaluation of Butea Monosperma Using in Vitro and in Vivo Murine Models of Bronchial Asthma

Shirole¹,

Sutariya²,

Saraf³

2013

Int. J. Res. Ayurveda Pharm.

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The present investigation aimed to elucidate the probable mechanism of antiasthmatic action of Butea monosperma. Bioactive fractionations of methanolic extract of B. monosperma (MBM) were carried out to get, ethyl acetate fraction (EBM) and butanolic fraction (BBM) of Butea monosperma. All fractions were evaluated mechanistically for its antiasthmatic actions in vitro using lipoxygenase assay. The lipoxygenase inhibitory effect of the extract followed the order BBM > MBM > EBM. Based on in vitro lipoxygenase assay BBM was selected for in vitro compound 48/80 induced mast cell degranulation assay and in vivo lipopolysaccharide induced inflammation in rats. BBM 50, 100 and 200μg/ml inhibited compound 48/80 induced mast cell degranulation. BBM exhibited dose dependent (50, 100 and 200mg/kg i.p.) inhibition of lipopolysaccharide-induced increased in total cell count, differential leukocyte count, nitrate-nitrite, total protein and albumin levels in bronchoalveolar fluid (BALF) and myeloperoxidase (MPO) levels in lungs homogenate.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 94%

Mechanistic Evaluation of Butea Monosperma Using in Vitro and in Vivo Murine Models of Bronchial Asthma

Shirole¹,

Sutariya²,

Saraf³

2013

Int. J. Res. Ayurveda Pharm.

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“…Traditionally, most of the plant parts are used for the treatment of various inflammatory, metabolic, and infectious diseases. The plant constituents have been reported to possess hepatoprotective (Wagner et al, 1986), anti-inflammatory (Shahavi and Desai, 2008), antidiabetic (Somani et al, 2006), antihelmintic (Iqbal et al, 2006), antidiarrheal (Gunakkunru et al, 2005), antifungal (Yadava and Tiwari, 2007), and antimicrobial (Gurav et al, 2008) activities. In short, approximately 45 medicinal uses are associated with this plant, and half of the number of claims have been scientifically studied and reported in the literature (Burli and Khade, 2007).…”

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confidence: 99%

Butrin, Isobutrin, and Butein from Medicinal PlantButea monospermaSelectively Inhibit Nuclear Factor-κB in Activated Human Mast Cells: Suppression of Tumor Necrosis Factor-α, Interleukin (IL)-6, and IL-8

Rasheed¹,

Akhtar²,

Khan³

et al. 2010

J Pharmacol Exp Ther

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Activation of mast cells in rheumatoid synovial tissue has often been associated with tumor necrosis factor (TNF)-␣, interleukin (IL)-6, and IL-8 production and disease pathogenesis by adjacent cell types. Butea monosperma (BM) is a well known medicinal plant in India and the tropics. The aim of this study was to examine whether a standardized extract of BM flower (BME) could inhibit inflammatory reactions in human mast cells (HMC) using activated HMC-1 cells as a model. Four previously characterized polyphenols-butrin, isobutrin, isocoreopsin, and butein-were isolated from BME by preparative thin layer chromatography, and their purity and molecular weights were determined by liquid chromatography/mass spectrometry analysis. Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-␣, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-B. In addition, isobutrin was most potent in suppressing the NF-B p65 activation by inhibiting IB␣ degradation, whereas butrin and butein were relatively less effective. In vitro kinase activity assay revealed that isobutrin was a potent inhibitor of IB kinase complex activity. This is the first report identifying the molecular basis of the reported anti-inflammatory effects of BME and its constituents butrin, isobutrin, and butein. The novel pharmacological actions of these polyphenolic compounds indicate potential therapeutic value for the treatment of inflammatory and other diseases in which activated mast cells play a role.

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“…7 Moreover, it is used for ethnoveterinary medicine and as a traditional medicine for many ailments in the various parts of India and South Asia [8][9][10][11] . Traditionally it has been found that flowers have anti-microbial 12 , wound healing 13 , anti-fungal 14 , anti-diarrhoeal 15 , hypoglycaemic 16 , hepatoprotective 17 , anti-convulsive 18 , anti-stress 19 , antidiabetic, antioxidant and anti-inflammatory activity 20 . Moreover, they also have the property of "Kapha" and "Vata" (Ayurveda) 21 .…”

Section: Quickmentioning

confidence: 99%

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2015

IJPSR

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Butea monosperma var. lutea, a native of India, is commonly known as "Palash" and popularly known as "Flame of Forest." Traditionally it has been found that flowers have antimicrobial, wound healing, antifungal, antidiarrhoeal, hypoglycemic, hepatoprotective, antioxidant, anthelmintic, anticonvulsive, antistress, antidiabetic, anti-inflammatory activity. In the present study, crude hydroalcoholic flower extract was examined for anticancer activity. To determine in-vitro anticancer activity, different concentrations of crude extract were tested on MCF-7 breast cancer cell line by 3-(4,5-dimethyl thiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The extract showed significant antiproliferative activity and a dose-dependent effect. Minimum inhibition 16.8% was shown by extract at concentration 62.5 µg/ml and maximum inhibition (46.89%) observed at 500 µg/ml. The flower extract showed activity in the potential range for further investigation of cancer cells.

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Anti-inflammatory activity of Butea monosperma flowers

Cited by 43 publications

References 8 publications

Mechanistic Evaluation of Butea Monosperma Using in Vitro and in Vivo Murine Models of Bronchial Asthma

Mechanistic Evaluation of Butea Monosperma Using in Vitro and in Vivo Murine Models of Bronchial Asthma

Butrin, Isobutrin, and Butein from Medicinal PlantButea monospermaSelectively Inhibit Nuclear Factor-κB in Activated Human Mast Cells: Suppression of Tumor Necrosis Factor-α, Interleukin (IL)-6, and IL-8

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