Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation

Lee, Doyeon; Choi, Goya; Yoon, Taesook; Cheon, Myeong Sook; Choo, Byung-Kil; Kim, Ho Kyoung

doi:10.1016/j.jep.2009.02.009

Cited by 97 publications

(45 citation statements)

References 21 publications

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“…In the study reported here, the effects of pre-treatment with an extract of Acacia ferruginea were evaluated using these model systems. Unlike earlier studies in which the anti-inflammatory effect of this extract was established in models of already extant inflammation (Lee at al., 2009;Mahmood et al, 2010), this study wanted to ascertain if the extract could also impart protective effects against subsequent induction of inflammation in situ. This approach would be in keeping with several other studies that examined effects of text agents (many of them natural products) against inducible inflammation in various animal models (Chao et al, 2009;Golechha et al, 2014;Kaur et al, 2004;Lucetti et al, 2010;Okokon et al, 2012).…”

Section: Discussionmentioning

confidence: 65%

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Sakthivel

Guruvayoorappan

2015

Journal of Immunotoxicology

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Inflammation is a local defensive reaction of a host to cellular injury or infection. Prolonged inflammation can contribute to pathogenesis of many disorders. Identification of naturally occurring phytoconstituents that can suppress inflammatory mediators can lead to the discovery of anti-inflammatory therapeutics. Acacia ferruginea is used traditionally to treat numerous ailments including hemorrhage, irritable bowel syndrome and leprosy. The present study evaluated the anti-inflammatory activity of A. ferruginea extract against acute (carrageenan) and chronic (formaldehyde) inflammation in Balb/c mice. Pre-treatment with A. ferruginea extract (10 mg/kg BW) for 5 consecutive days via intraperitonial (IP) administration significantly inhibited subsequent induction of paw edema in both models; the effects were comparable to that of the standard drug indomethacin. The results also showed the A. ferruginea extract significantly inhibited nitric oxide (NO) synthesis and iNOS expression (as measured in serum), diminished inflammation in -and neutrophil infiltration to -the paw tissues and led to a reduction in the number of COX-2 + immunoreative cells (as evidenced by histologic and immunohistochemical analyses) in the paws relative to those in paws of mice that received the irritants only. Further, in vitro studies showed the extract could significantly scavenge free radicals generated as in DPPH and NO radical generating assays. Taken together, the results showed that A. ferruginea extract imparted potent anti-oxidant and -inflammatory effects, in part by maintaining oxidative homeostasis, inhibiting NO synthesis and suppressing iNOS and COX-2 expression and so could potentially be exploited as a potential plant-based medication against inflammatory disorders.

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Section: Discussionmentioning

confidence: 65%

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Sakthivel

Guruvayoorappan

2015

Journal of Immunotoxicology

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“…Chrysanthemum (Asteraceae) is a large genus of about 300 species (Kumar et al, 2005) from which Chrysanthemum fontanesii growing in algeria. A series of studies have demonstrated that Chrysanthemum species possesses antioxidants (Duh et al, 1999;Lin et al, 2010;Liu et al, 2012;, anticancer (Bi et al, 2008;Jin et al, 2009) (Shunying et al, 2005), anti-inflammatory (Lee et al, 2009;Kim et al, 2012), immunomodulatory (Cheng et al, 2005), Hepatoprotective (Amrani et al, 2013 b ) and neuroprotective effects (Chun et al, 2008).Many chemical compounds have been isolated and identified from species of the Chrysanthemum (Benaissa et al, 2011, Lograda et al, 2013. Based on these effects this study was designed to determine the possible protective effect of the n-butanol extract obtained from flowers of Chrysanthemum fontanesii against oxidative damage of kidneys induced by VPA.…”

Section: Introductionmentioning

confidence: 99%

Impact of Chrysanthemum fontanesii extract on sodium valproate mediated oxidative damage in mice kidney

Amrani

Benaissa²,

Boubekri³

et al. 2016

J App Pharm Sci

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The objective of this study was to evaluate the potential of n-butanol extract obtained from flowers of Chrysanthemum fontanesii (Cf) and vitamin E against kidney oxidant injury induced by sodium valproate in mice. The evaluation was made through Histopathological examination and measuring kidney lipid peroxidation (LPO) and antioxidant parameters: reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase. Severe alterations in all biomarkers were observed after injury with VPA. Treatment with Cf extract and vitamin E resulted in markedly decreased levels of LPO while increased levels of GSH and antioxidant enzymes activities were observed. In conclusion, n-butanol extract of Cf may be an interesting candidate for the treatment of kidney injury induced by VPA through enhancing endogenous antioxidant defenses and normalizing the kidney histopathological architecture.

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“…Several investigators are working to develop effective cytokine-modulating anti-inflammatory therapies for treating sepsis (Surh, 2002;Byun, 2005;Yoon et al, 2007;Yun et al, 2008), and numerous natural products (e.g., Scutellariae radix, chrysanthemum indicum L., Pulsatilla koreana, and Allium victorialis) have been investigated for their anti-inflammatory effects in this laboratories (Lee, 2007;Lee, 2009;Lee et al, 2012;Lee, 2014), but no satisfactory results have been reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of Trifoliate Orange (Poncirus trifoliata) Extract on Inflammatory Responses in LPS-induced Shock Rats and RAW 264.7 Cells

Lee¹

2016

Korean Journal of Plant Resources

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-This study examined the effects of trifoliate orange extract (TOE) on inflammatory reactions at the time of an LPS shock by performing experiments on rats injected with trifoliate orange extract and in Raw 264.7 cell cultures, with the aim of developing a new anti-inflammatory medicine. The IL-1β, IL-6, and TNF-α concentrations were lower in all of the groups treated with TOE than in the control group after 5 h of LPS treatment. The IL-10 concentration was higher in the 300-㎎/㎏ TOE group than in the control group after 2 h and 5 h of LPS treatment. The liver concentrations of cytokines IL-1β and IL-6 decreased more in the groups treated with TOE than in the control group and the IL-6 concentration did not differ significantly between the 100-㎎/㎏ TOE group than in the control group. The TNF-α and IL-10 concentrations did not differ significantly between the TOE groups and the control group. In the experiments involving Raw 264.7 macrophage cultures subjected to LPS shock, the productions of IL-1β, IL-6, and TNF-α decreased in all of the groups treated with TOE compared to the control group. The IL-10 concentration did not differ significantly between the groups treated with TOE and the control group. Together the findings of this study suggest that TOE contains functional substances that can influence inflammatory reactions.

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Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation

Cited by 97 publications

References 21 publications

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

Impact of Chrysanthemum fontanesii extract on sodium valproate mediated oxidative damage in mice kidney

Effects of Trifoliate Orange (Poncirus trifoliata) Extract on Inflammatory Responses in LPS-induced Shock Rats and RAW 264.7 Cells

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