Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages

Jung, Hyun Ah; Jin, Seong Eun; Ahn, Bo Ra; Lee, Chan Mee; Choi, Jae Sue

doi:10.1016/j.fct.2013.05.061

Cited by 207 publications

(129 citation statements)

References 59 publications

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“…Seaweed polysaccharides have various biological activities, including anti-inflammation (Coura et al, 2012;Jung, Jin, Ahn, Lee, & Choi, 2013;Simpi, Nagathan, Karajgi, & Kalyane, 2013). NO is an inflammatory mediator induced by inflammatory cytokines or bacterial LPS in various cell types including macrophages (Swindle & Metcalfe, 2007).…”

Section: Effect Of the Seaweed Polysaccharides On No Secretionmentioning

confidence: 99%

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

et al. 2016

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Section: Effect Of the Seaweed Polysaccharides On No Secretionmentioning

confidence: 99%

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

et al. 2016

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“…The antioxidant activity of E. bicyclis phlorotannins, such as eckol (a trimer), phlorofucofuroeckol A (a pentamer), dieckol and 8,8′-bieckol (hexamers) have been previously described (Okada et al 2004). This brown alga has also been reported to exhibit several medicinal functions, such as anti-tumor (Ermakova et al 2013), anti-Alzheimer's disease (Ahn et al 2012), anti-atherosclerosis (Kang et al 2006), antiinflammatory (Jung et al 2013), anti-coagulant activities (Jeong et al 2009), anti-allergic disease and anti-cancer activities (Shibata et al 2003). In addition, phlorotannins have been known to show potent antimicrobial activity against several microorganisms (Eom et al 2013).…”

Section: Microorganism and Culturementioning

confidence: 99%

In vitro antibacterial and synergistic effect of phlorotannins isolated from edible brown seaweed Eisenia bicyclis against acne-related bacteria

Lee¹,

Eom²,

Lee³

et al. 2014

ALGAE

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To develop effective and safe acne vulgaris therapies with a continuing demand for new solutions, we investigated unique efficacy of an antibacterial agent from marine brown alga Eisenia bicyclis in treating acne vulgaris. The methanolic extract of E. bicyclis exhibited potential antibacterial activity against acne-related bacteria. The ethyl acetate fraction showed the strongest antibacterial activity against the bacteria among solvent fractions. Six compounds (1-6), previously isolated from the ethyl acetate fraction of E. bicyclis, were evaluated for antibacterial activity against acne-related bacteria. Among them, compound 2 (fucofuroeckol-A [FF]) exhibited the highest antibacterial activity against acne-related bacteria with a minimum inhibitory concentration (MIC) ranging from 32 to 128 μg mL -1 . Furthermore, FF clearly reversed the high-level erythromycin and lincomycin resistance of Propionibacterium acnes. The MIC values of erythromycin against P. acnes were dramatically reduced from 2,048 to 1.0 μg mL -1 in combination with MIC of FF (64 μg mL -1). The fractional inhibitory concentration indices of erythromycin and lincomycin were measured from 0.500 to 0.751 in combination with 32 or 64 μg mL -1 of FF against all tested P. acnes strains, suggesting that FF-erythromycin and FF-lincomycin combinations exert a weak synergistic effect against P. acnes. The results of this study suggest that the compounds derived from E. bicyclis can be a potential source of natural antibacterial agents and a pharmaceutical component against acnerelated bacteria.Key Words: acne-related bacteria; antimicrobial activity; Eisenia bicyclis; phlorotannins; synergistic effect INTRODUCTIONAcne vulgaris is a common skin disease affecting children and adolescents. The pathogenesis of acne is multifactorial and complex. There are four important factors that cause acne in humans, such as an increase in sebum secretion, keratinization of the follicle, bacteria, and inflammation (Farrar and Ingham 2004). Pro pionibacterium acnes, Staphylococcus epidermidis, S. aureus, and Pseudomonas aeruginosa are often involved in the development of abnormal follicular keratinization and inflammation (Yamaguchi et al. 2009 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 48 MATERIALS AND METHODS Raw materials and extractionIn late September 2010, E. bicyclis was purchased from Ulleung Trading Co. (Ulleung-gun, Korea). A voucher specimen has been deposited in the author's laboratory. Dried E. bicyclis was finely ground and powdered with a food mixer (HMF-1000A; Hanil Electronics, Seoul, Korea). The dried powder was vacuum-packed and kept at -20°C until use. The dried E. bicyclis powder (1.0 kg) was extracted with methanol (MeOH; 10 L × 3) at 70°C for 3 h (3 times) and the solvent was evaporated ...

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“…67 They also display anti-allergy, anti-coagulative, anti-hypertensive, anti-diabetic, immuno-modulatory, antimutagenic, anti-tumour and anti-cancer activity and can reasonably be categorised as gerosuppressants. [55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] In light of the above, it seems probable that many and perhaps all the health benefits associated with the tradition Inuit diet, and which were attributed to the o3 highly unsaturated fatty acids they consumed, were at least partly due to their co-ingestion of phlorotannins.…”

Section: Pluripotent Polyphenolsmentioning

confidence: 99%

“…The phlorotannins are potent anti-inflammatory agents [55][56][57][58][59][60][61][62][63] via mechanisms (including inter alia the inhibition and/or downregulation of COX-1 and -2, LIPOX-5 and -8, and the MMP group of enzymes) which complement those of the o3 fatty acids. They demonstrate vaso-protective properties in vitro 64 and in vivo;…”

Section: Pluripotent Polyphenolsmentioning

confidence: 99%

From alga to omega; have we reached peak (fish) oil?

Clayton

Ladi

2015

J R Soc Med

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While the Inuit diet was highly cardio-protective and consuming oily fish within a Western diet is to a lesser degree, the case for purified fish oil supplements is less convincing. Purification of fish oil removes lipophilic polyphenols which likely contribute to the health benefits of oily fish; leaving the o3 highly unsaturated fatty acids exposed and prone to conferring oxidative and inflammatory stress. The authors believe that due to such issues as dietary shift, it may now be inadvisable to prescribe or sell purified o3 highly unsaturated fatty acids supplements, unless the appropriate co-factors are included.

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Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages

Cited by 207 publications

References 59 publications

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

Anti-inflammatory activity of a sulfated polysaccharide from the brown alga Sargassum cristaefolium

In vitro antibacterial and synergistic effect of phlorotannins isolated from edible brown seaweed Eisenia bicyclis against acne-related bacteria

From alga to omega; have we reached peak (fish) oil?

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