Anti-Inflammatory Activity of Four Triterpenoids Isolated from Poriae Cutis

Zhang, Lijia; Yin, M.; Feng, Xi; Ibrahim, Salam A.; Liu, Ying; Huang, Wen

doi:10.3390/foods10123155

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…Previous study found that poricoic acid A could protect against acute kidney injury-to-chronic kidney disease transition in rats and attenuate fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis (Chen DQ et al, 2019;Chen DQ et al, 2020). Poricoic acid B could decrease the production of cytokines (TNF, IL-1B, and IL-6) (Zhang et al, 2021). And our data showed that poricoic acid C might interact with TNF and thus ameliorate renal injury of DKD.…”

Section: Discussionmentioning

confidence: 53%

Using network pharmacology to explore the mechanism of Danggui-Shaoyao-San in the treatment of diabetic kidney disease

Yang

Liu

et al. 2022

Front. Pharmacol.

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Danggui-Shaoyao-San (DSS) is one of traditional Chinese medicine, which recently was found to play a protective role in diabetic kidney disease (DKD). However, the pharmacological mechanisms of DSS remain obscure. This study would explore the molecular mechanisms and bioactive ingredients of DSS in the treatment of DKD through network pharmacology. The potential target genes of DKD were obtained through OMIM database, the DigSee database and the DisGeNET database. DSS-related targets were acquired from the BATMAN-TCM database and the STITCH database. The common targets of DSS and DKD were selected for analysis in the STRING database, and the results were imported into Cytoscape to construct a protein-protein interaction network. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analysis and Gene Ontology (GO) enrichment analysis were carried out to further explore the mechanisms of DSS in treating DKD. Molecular docking was conducted to identify the potential interactions between the compounds and the hub genes. Finally, 162 therapeutic targets of DKD and 550 target genes of DSS were obtained from our screening process. Among this, 28 common targets were considered potential therapeutic targets of DSS for treating DKD. Hub signaling pathways including HIF-1 signaling pathway, TNF signaling pathway, AMPK signaling pathway, mTOR signaling pathway, and PI3K-Akt signaling pathway may be involved in the treatment of DKD using DSS. Furthermore, TNF and PPARG, and poricoic acid C and stigmasterol were identified as hub genes and main active components in this network, respectively. In this study, DSS appears to treat DKD by multi-targets and multi-pathways such as inflammatory, oxidative stress, autophagy and fibrosis, which provided a novel perspective for further research of DSS for the treatment of DKD.

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Section: Discussionmentioning

confidence: 53%

Using network pharmacology to explore the mechanism of Danggui-Shaoyao-San in the treatment of diabetic kidney disease

Yang

Liu

et al. 2022

Front. Pharmacol.

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“…In this study, we identified poricoic acid B and polyporenic acid C as 6.7% and 28.1% of EPC, respectively. Pharmacological studies showed that porcine acid B has a strong anti-inflammatory effect ( Zhang et al, 2021 ). Polyporenic acid C potentiates insulin and induces differentiation of ST-13 preadipocytes ( Yang et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway

Zhang

et al. 2022

Front. Pharmacol.

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Despite the increase in the global prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD), no approved drug currently exists for the disease. Poria cocos (Schw.) Wolf (P. cocos) is a medicinal mushroom belonging to a family of polyporaceae widely used in TCM clinics to protect the liver and treat obesity. However, its efficacy, practical components, and underlying mechanism against MAFLD are yet to be determined. In this study, we evaluated the effects of Poria cocos (P. cocos) ethanol extract (EPC) on hepatic dyslipidemia, steatosis, and inflammation by both bioinformatics analysis and MAFLD rats induced by HFD feeding. We found EPC treatment dramatically reduced lipid accumulation, inflammatory cell infiltration, and liver injury. EPC reduced serum TC, TG levels, and hepatic TG, TBA, and NEFA contents. UHPLC Q-Trap/MS examination of BA profiles in serum and feces showed that EPC increased fecal conjugated BAs, decreased free BAs, and improved BA metabolism in HFD-fed rats. Western blot and RT-qPCR analysis showed that EPC could activate hepatic FXR and PPARα expression and reduce CYP7A1 and SREBP-1c expression. Systemic pharmacology combined with molecular docking suggested that poricoic acid B and polyporenic acid C, the major active compounds in EPC, could ameliorate lipid homeostasis by activating the nuclear receptor PPARα. We further confirmed their inhibition effects of lipid droplet deposition in steatized L-02 hepatocytes. In summary, EPC alleviated HFD-induced MAFLD by regulating lipid homeostasis and BA metabolism via the FXR/PPARα-SREBPs signaling pathway. P. cocos triterpenes, such as poricoic acid B and polyporenic acid C, were the characteristic substances of P. cocos for the treatment of MAFLD.

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“…PAA appears to modulate multiple important signaling pathways, including NF-kB, PI3K/Akt (phosphatidylinositol-3-kinase/protein kinase B), and TGF-b, exerting anti-fibrotic effects in vivo and in vitro [10,11]. In addition, our laboratory study showed that PAB had higher anti-inflammatory activity than PAA by inhibiting NO production in RAW 264.7 cells induced by lipopolysaccharide (LPS) [12]. Studies have also found that PAA has an inhibitory effect on colon, kidney, prostate and breast cancer cells [13].…”

Section: X For Peer Review 2 Of 18mentioning

confidence: 79%

“…In our previous studies, it was shown that triterpenes promote the production of TNF-alpha, which plays a role in cell death and tumor progression [12]. It has been shown that tumor necrosis factor alpha can act directly on tumor cells and induce ROS within them, which is the rationale behind the use of cellular immunotherapy for targeted elimination of cancer cells [34].…”

Section: Effect Of Paa and Pab On Ros Production In Hepg2 Cellsmentioning

confidence: 99%

Regulation of Tumor Apoptosis of Poriae cutis-Derived Lanostane Triterpenes by AKT/PI3K and MAPK Signaling Pathways In Vitro

Yue,

Feng,

Cai

et al. 2023

Nutrients

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Poria cocos is traditionally used as both food and medicine. Triterpenoids in Poria cocos have a wide range of pharmacological activities, such as diuretic, sedative and tonic properties. In this study, the anti-tumor activities of poricoic acid A (PAA) and poricoic acid B (PAB), purified by high-speed counter-current chromatography, as well as their mechanisms and signaling pathways, were investigated using a HepG2 cell model. After treatment with PAA and PAB on HepG2 cells, the apoptosis was obviously increased (p < 0.05), and the cell cycle arrested in the G2/M phase. Studies showed that PAA and PAB can also inhibit the occurrence and development of tumor cells by stimulating the generation of ROS in tumor cells and inhibiting tumor migration and invasion. Combined Polymerase Chain Reaction and computer simulation of molecular docking were employed to explore the mechanism of tumor proliferation inhibition by PAA and PAB. By interfering with phosphatidylinositol-3-kinase/protein kinase B, Mitogen-activated protein kinases and p53 signaling pathways; and further affecting the expression of downstream caspases; matrix metalloproteinase family, cyclin-dependent kinase -cyclin, Intercellular adhesion molecules-1, Vascular Cell Adhesion Molecule-1 and Cyclooxygenase -2, may be responsible for their anti-tumor activity. Overall, the results suggested that PAA and PAB induced apoptosis, halted the cell cycle, and inhibited tumor migration and invasion through multi-pathway interactions, which may serve as a potential therapeutic agent against cancer.

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Anti-Inflammatory Activity of Four Triterpenoids Isolated from Poriae Cutis

Cited by 11 publications

References 30 publications

Using network pharmacology to explore the mechanism of Danggui-Shaoyao-San in the treatment of diabetic kidney disease

Using network pharmacology to explore the mechanism of Danggui-Shaoyao-San in the treatment of diabetic kidney disease

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway

Regulation of Tumor Apoptosis of Poriae cutis-Derived Lanostane Triterpenes by AKT/PI3K and MAPK Signaling Pathways In Vitro

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