Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells

Abstract

Abstract:The inhibitory effect of three chromones 1-3 and two coumarins 4-5 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In addition, heterocarpin suppressed prostaglandin E2 (PGE2) production and expression of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6).

Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts

“…The MeOH fractions which were suggested to be a phenol-rich extract (Seo et al 2004;Shipeng et al 2015), therefore, were suggested to inhibit the enzymatic activity of MMPs through direct interaction. The n-BuOH fractions which were reported to be rich in chromones and coumarins (Kim et al 2015), however, were able to regulate the intracellular pathways of MMP expression while having little to no effect on enzymatic activity. Fig.…”

Evaluation of the Nano-TiO2 as a Novel Deswelling Material

“…The endothelium of blood vessels uses NO to signal the surrounding smooth muscle to relax, thus resulting in vasodilation [3,4,5]. Recent studies have shown that NO is also essential for host innate immune responses to pathogens such as viruses, bacteria, fungi, and parasites, which is mainly generated by macrophages [6,7,8,9]. However, excessive production of NO is a common feature of most diseases associated with infection and acute or chronic inflammation, which contributes to edema formation and pain sensitization [10,11].…”

Chromones: A Promising Ring System for New Anti‐inflammatory Drugs

“…The anti‐inflammatory effect of three natural chromones isolated from the plant Corydalis heterocarpa Siebold & Zucc., was assessed by measuring . NO production in LPS‐stimulated RAW 264.7 cells . The results showed that only one of the tested chromones, heterocarpin ( 31 ; Figure ), inhibited .…”