Anti-inflammatory activity of Indonesian polyherbal product containing <i>Curcuma zanthorrhiza</i> and <i>Vitex trifolia</i> as the main ingredients in carrageenan- and histamine-induced inflammation in Wistar rats

Ikawati, Zullies; Hertiani, Triana; Hartanti, Yesiska Kristina; Sigalih, Niken Laras

doi:10.52547/jmp.21.84.39

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…The calculation of anti-inflammatory potency followed the method of Ikawati et al [26] with slight modifications, where antiinflammatory potency was determined by the volume of edema (Ve) obtained from the formula Ve = Vt-Vo. The area under the curve (AUC) represents the amount of inflammation obtained from Ve versus time.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Ibuprofen Injectable Microemulsion Preparation Coated by Chitosan: Formulation, Characterization, in Vitro Performance, Anti-Inflammation Activity, and Hematology Assessment

UL HAFIZAH,

SUGITA,

KHOTIB

et al. 2024

Int J App Pharm

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Objective: This study aimed to develop, characterize, and conduct stability evaluations to ensure compliance with intravenous administration for microemulsion ibuprofen injection. In addition, hematology assessment and profile of drug release kinetics were analyzed. Methods: The formulation process commenced by introducing various chitosan concentrations into microemulsion ibuprofen injection, following a method established in a previous study. Formulation parameters studied include particle size, polydispersity index (PDI), zeta potential, kinetic of drug release, anti-inflammation activity using the 1% carrageenin induction method, and hematology assessment. Results: The results showed that the addition of 1% chitosan solution allowed for the development of the ideal microemulsion formula, with droplet size, zeta potential, and PDI of 19.37±0.32 nm,-1.53±0.12 mV, and 0.38±0.02, respectively. Kinetics of chitosan-coated ibuprofen microemulsion (MK) were governed by the squared root of time paradigm, suggesting that drug release proceeded by diffusion and was influenced by the carrier. Compared to the other groups, the paw injected with MK indicated a strong anti-inflammatory effect and did not differ significantly from the control group (p>0.05). However, Hematology analysis showed no statistically significant variations in leukocyte and erythrocyte profiles between the treatment and control groups (p>0.05). Conclusion: MK met the criteria as an intravenous preparation based on the characteristics and safety.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Ibuprofen Injectable Microemulsion Preparation Coated by Chitosan: Formulation, Characterization, in Vitro Performance, Anti-Inflammation Activity, and Hematology Assessment

UL HAFIZAH,

SUGITA,

KHOTIB

et al. 2024

Int J App Pharm

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Antiedematogenic and Anti‐Inflammatory Effects of the Essential Oil from the Fruits of Piper tuberculatum Jacq. (Piperaceae) in Animal Models

Santos da Silva,

Torres Pessoa,

Sousa Alcântara

et al. 2024

Chemistry & Biodiversity

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Piper tuberculatum, traditionally known as 'pimenta‐d'arda,' 'pimenta‐longa,' or 'pimenta de macaco,' has been used in Brazilian folk medicine to treat inflammatory symptoms, It is used for its sedative effects in pain relief. Considering this species' significant essential oil content, the present study aimed to evaluate the anti‐edematogenic and anti‐inflammatory effects of the essential oil Piper tuberculatum (EOPT) in vivo. To this end, Swiss mice (Mus musculus) of both sexes were treated orally with the EOPT at 50, 100, and 250 mg/Kg. The rotarod and open field evaluated the potential activity in the central nervous system. At the same time, formalin and abdominal writhing tests were carried out to perform the pharmacological screening of the essential oil. Next, the anti‐edematogenic effect was assessed using paw edema models induced by carrageenan, dextran, histamine, and arachidonic acid. The anti‐inflammatory activity was then characterized in peritonitis (acute) and granuloma (chronic) models. All the EOPT doses (50, 100, and 250 mg/kg) had analgesic effects associated with anti‐inflammatory mechanisms in screening models. Accordingly, the treatment (EOPT 100 mg/Kg) inhibited the inflammatory process in acute and chronic models. In conclusion, EOPT has analgesic, antiedematogenic, and anti‐inflammatory effects, highlighting its potential use in developing anti‐inflammatory drugs.

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Anti-inflammatory activity of Indonesian polyherbal product containing Curcuma zanthorrhiza and Vitex trifolia as the main ingredients in carrageenan- and histamine-induced inflammation in Wistar rats

Cited by 2 publications

References 27 publications

Ibuprofen Injectable Microemulsion Preparation Coated by Chitosan: Formulation, Characterization, in Vitro Performance, Anti-Inflammation Activity, and Hematology Assessment

Ibuprofen Injectable Microemulsion Preparation Coated by Chitosan: Formulation, Characterization, in Vitro Performance, Anti-Inflammation Activity, and Hematology Assessment

Antiedematogenic and Anti‐Inflammatory Effects of the Essential Oil from the Fruits of Piper tuberculatum Jacq. (Piperaceae) in Animal Models

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