Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model

The effect of silver nanoparticles on splenocyte activity and selected cytokine levels in the mouse serum at early stage of experimental endotoxemia

“…On the other hand, in experiments investigating the effect of silver nanoparticle dressing or cream in the treatment of allergic contact dermatitis or chronic and infected wounds in animals, the authors have demonstrated satisfactory clinical results, including a fast reduction of swelling and hyperemia, accelerated healing and correct histological images of the tissue affected (Wright et al 2002, Bhol et al 2004, Bhol and Schechter 2005, Tian et al 2007, Nadworny et al 2008. In studies describing the humoral immune response, silver nanoparticles were shown to lower the serum level of acute-phase proteins, reduce collagenase activity, lower tissue metalloproteinase levels and proinflammatory cytokine expression or modulate cytokine expression -a drop in IL-6 mRNA levels, an increase in TGF-β1 mRNA expression at the beginning of healing, followed by a successive drop, and an increase in IL-10, VEGF and IFN-γ mRNA levels (Wright et al 2002, Bhol and Schechter 2005, Tian et al 2007, Nadworny et al 2008).…”

“…In studies describing the humoral immune response, silver nanoparticles were shown to lower the serum level of acute-phase proteins, reduce collagenase activity, lower tissue metalloproteinase levels and proinflammatory cytokine expression or modulate cytokine expression -a drop in IL-6 mRNA levels, an increase in TGF-β1 mRNA expression at the beginning of healing, followed by a successive drop, and an increase in IL-10, VEGF and IFN-γ mRNA levels (Wright et al 2002, Bhol and Schechter 2005, Tian et al 2007, Nadworny et al 2008). This beneficial effect could result from differences in the manner of AgNP administration and the direct application of silver nanoparticles to the site of inflammation, which does not rule out a completely different model of activity of orally administered AgNPs.…”

Synergistic effects between silver nanoparticles and antibiotics and the mechanisms involved

“…Nano-Ags are a non-toxic and safe antibacterial agent for the human body. In addition, nano-Ags are also reported to possess antifungal activity (Kim et al, 2009), antiinflammatory properties (Nadworny et al, 2008), antiviral activity (Rogers et al, 2008) and anti-angiogenic activity (Gurunathan et al, 2009). Nano-Ags can be applied safely in therapy when the effective concentrations against various types of organisms have been determined.…”

Investigation of lichen based green synthesis of silver nanoparticles with response surface methodology

“…Among the metal nanoparticles, silver (Ag) nanoparticles have attracted considerable attention due to their wide applicability [2][3][4][5]. In addition to their antibacterial activity which has been known since ancient times [6], various attributes of Ag nanoparticles have been determined such as antifungal activity [7], antiinflammatory effects [8] antiviral activity [9] antiangiogenesis activity [10] and antiplatelet activity [11]. There is a variety of chemical and physical techniques to prepare metal nanoparticles, such as chemical reduction [12,13], electrochemical reduction [14,15], photochemical reduction [16,17] and heat evaporation [18,19].…”