Anti-inflammatory activity of niosomes entrapped with Plai oil (&lt;em&gt;Zingiber cassumunar&lt;/em&gt; Roxb.) by therapeutic ultrasound in a rat model

Leelarungrayub, Jirakrit; Manorsoi, Jiradej; Manorsoi, Aranya

doi:10.2147/ijn.s129131

Cited by 37 publications

(34 citation statements)

References 30 publications

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“…In recent years, some reports relate pathogen infection to the development and progression of chronic inflammation. In this systematic review, we found 9 studies reporting inflammatory conditions induced by microorganisms or their components, including LPS from E. coli , complete Freund's adjuvant, S. flexneri , and P. multocida [22, 31, 34, 36, 39, 40, 44, 50]. LPS is the major cause of endotoxemia and sepsis.…”

Section: Resultsmentioning

confidence: 99%

“…For this, isolated tests of in vitro antioxidant activity, such as DPPH, inhibition of β -carotene degradation, ABTS, NO, and FRAP tests, were used as initial screening of the pharmacological activity of EOs or isolated substances. Based on the satisfactory results obtained, some anti-inflammatory activity tests were subsequently conducted [24, 27, 29–31, 40, 48, 50]. In contrast, other studies, especially in vivo studies, assessed the anti-inflammatory activity and at the end of the experiment the animals were euthanized and blood collected for serum levels indicating enzymes of oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

“…The anti-inflammatory action of this oil is probably related to the presence of sabinene and terpinen-4-ol (major compounds) which reduce the expression of NF- κ B and interleukin-6. The antioxidant tests indicated antioxidant activity of the EO, which inhibited DPPH radical, demonstrating once again the relation of inflammatory processes and antioxidant mechanisms [50].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

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Fernandes

Teles

et al. 2018

Oxidative Medicine and Cellular Longevity

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Inflammatory diseases result from the body's response to tissue damage, and if the resolution is not adequate or the stimulus persists, there will be progression from acute inflammation to chronic inflammation, leading to the development of cancer and neurodegenerative and autoimmune diseases. Due to the complexity of events that occur in inflammation associated with the adverse effects of drugs used in clinical practice, it is necessary to search for new biologically active compounds with anti-inflammatory activity. Among natural products, essential oils (EOs) present promising results in preclinical studies, with action in the main mechanisms involved in the pathology of inflammation. The present systematic review summarizes the pharmacological effects of EOs and their compounds in in vitro and in vivo models for inflammation. The research was conducted in the following databases: PubMed, Scopus, BIREME, Scielo, Open Grey, and Science Direct. Based on the inclusion criteria, 30 articles were selected and discussed in this review. The studies listed revealed a potential activity of EOs and their compounds for the treatment of inflammatory diseases, especially in chronic inflammatory conditions, with the main mechanism involving reduction of reactive oxygen and nitrogen species associated with an elevation of antioxidant enzymes as well as the reduction of the nuclear factor kappa B (NF-κB), reducing the expression of proinflammatory cytokines. Thus, this review suggests that EOs and their major compounds are promising tools for the treatment of chronic inflammation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Lavor

Fernandes

Teles

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Encapsulation of compound D in niosomes enhanced its chemical stability and skin permeation with anti-inflammatory effects comparable to commercial anti-inflammatory drugs when applied on the skin of mice [90]. Z. cassumunar-encapsulated niosomes were also effective for local subcutaneous inflammation when used in combination with therapeutic ultrasound [91].…”

Section: Inflammationmentioning

confidence: 96%

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

et al. 2017

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Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes' structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

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“…The safety and efficacy of such systems prove to be its trademark and is attractive for formulations, diagnostics and vaccine preparations. It is custom-fit to wide requirements by considering the cost, toxicity due to treatments like ultrasound, efficacy, and stability including indications of a disease [36]. The advantages of such systems are extensive:…”

Section: Lipid-based Drug Carriersmentioning

confidence: 99%

Enzymosomes: A Rising Effectual Tool for Targeted Drug Delivery System

et al. 2017

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The study aims to develop enzymosomes as an emerging novel drug delivery system for site-specific action. Enzymosomes utilises the specific nature of an enzyme, which is binding to a specific substrate at a controlled rate and catalysing product production step. An enzyme is encapsulated by coupling covalently to the surface of liposomes/lipid vesicles to form enzymosomes. Enzymes links through acylation, direct conjugation, physical adsorption, encapsulation methods to prepare enzymosomes with targeted action. Such novel drug delivery systems prove effective drug release and concomitantly reduces undesirable side effects of conventional treatment methods and hence showcase improvement in the long-term therapy of the disease. They are a promising substitute to conventional treatment therapies of gout, antiplatelet activities etc. Enzymosomes are newly designed supramolecular vesicular delivery systems to be useful as a tool in pharmaceutics for the raising of drug targeting and physicochemical properties and hence bioavailability. It shows beneficial effects of drugs with a narrow precision because targeting of these drugs to their site of action improves the drugs overall pharmacodynamics and pharmacokinetic profile. It also minimizes alterations in the normal enzymatic activity, thus enhancing half-life and achieve enzyme activity on targeted sites such as cancerous cells.

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Anti-inflammatory activity of niosomes entrapped with Plai oil (<em>Zingiber cassumunar</em> Roxb.) by therapeutic ultrasound in a rat model

Cited by 37 publications

References 30 publications

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Essential Oils and Their Major Compounds in the Treatment of Chronic Inflammation: A Review of Antioxidant Potential in Preclinical Studies and Molecular Mechanisms

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Enzymosomes: A Rising Effectual Tool for Targeted Drug Delivery System

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