Anti-Inflammatory Activity of Selected Plants from Saudi Arabia

Abdallaha, Hossam M.; Abdel-Naimc, Ashraf B.; Ashourd, Osama M.; Shehataa, Ibrahim A.; Abdel-Sattarb, Essam A.

doi:10.5560/znc.2012-0168

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…Classical anti-inflammatory drugs (non-steroidal; selective and non-selective) showed severe side effects including renal failure and showed harmful effect on GIT and cardiovascular system [1,3]. In this context; drugs of natural origin are widely used due to their effectiveness, lesser side effects and their relative economic cost [4]. Several plants and plant-derived active compounds demonstrated anti-inflammatory activity [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory Activity and Chemical Characterisation of Opuntia ficus-indica Seed Oil Cultivated in Saudi Arabia

et al. 2020

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The fruits of Opuntia ficus-indica (L.) Mill. (OFI), a member of the family Cactaceae, is cultivated in Saudi Arabia and considered as a functional food with anti-inflammatory activity.The aim of current study was to chemically characterise OFI growing in Saudi Arabia by GC-MS and evaluate its anti-inflammatory activity in rat models via carrageenan-induced paw oedema and croton oil-induced ear oedema at two doses 100 and 200 mg/kg. Palmitic acid (10.68%), linoleic acid (5.9%), oleic acid (8.16%) and β-sitosterol (24.98%) are the major constituents in OFI seed oil. In carrageenan-induced rats, the OFI seed oil (100 and 200 mg/kg) produced significant inhibition of oedema by approximately 46% and 62%, respectively, and reduced PGE2 concentrations in exudates by 54% and 67%, respectively. Also, it significantly decreased the weight of punch from challenged ears by 20% and 33%, and myeloperoxidase (MPO) activity by 54% and 62% of the induced ear respectively. This was accompanied by amelioration of croton oil induced histopathological changes. In conclusion, the antiinflammatory activity of the OFI seed oil might be attributed to the presence of USFA such as oleic acid (omega-9) in addition to β-sitosterol through decreasing PGE2 and MPO activity in the inflamed tissues which was supported by histopathological examination.

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Section: Introductionmentioning

confidence: 99%

“…Plant-based drugs are widely used due to their proven effectiveness, reduced side effects and their relative economic cost [4]. The kingdom of Saudi Arabia is rich in plants; including about 2250 in a different region of Saudi Arabia [10].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Activity and Chemical Characterisation of Opuntia ficus-indica Seed Oil Cultivated in Saudi Arabia

et al. 2020

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“…The TFC of the TME was estimated by the AlCl 3 complex assay [17]. A calibration curve for quercetin (standard) was drawn.…”

Section: Determination Of the Tfcmentioning

confidence: 99%

Pulicaria petiolaris effectively attenuates lipopolysaccharide (LPS)-induced acute lung injury in mice

Ahmed

Aljuhani

Salamah

et al. 2018

ARCH BIOL SCI BELGRA

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Members of the genus Pulicaria have been used in traditional medicine for alleviating several complaints as they have a rich pool of biometabolites. Acute lung injury (ALI) is a serious disease with an elevated mortality rate. The present investigation aimed to evaluate the total phenolic and flavonoid contents and antioxidant capacity of the methanolic extract of P. petiolaris Jaub. and Spach. (PP) (Asteraceae). Moreover, the potential protective potential of PP against lipopolysaccharide-(LPS)-induced ALI was assessed. PP is a rich source of phenolics and flavonoids. The total phenolic content (TPC) was 68.05 mg gallic acid equivalent (GAE)/g dried extract, and the total flavonoid content (TFC) was 45.86 mg quercetin equivalent (QE)/g dried extract. Additionally, PP possessed a promising DPPH-scavenging activity, with an IC 50 =27 μg/mL. Our results showed that PP lessened LPS-induced lung injury. PP effectively reduced pulmonary edema as it lowered total protein and the lung wet/dry weight (W/D) ratio in the bronchoalveolar lavage fluid (BALF). It also significantly ameliorated the level of lactate dehydrogenase (LDH) in the BALF and improved the histopathological lesions in the lung tissue. LPS-induced inflammatory cell infiltration was greatly depressed in PP-treated animals. PP showed antioxidant capacity as it reduced the LPS-induced increase in the lipid peroxidation marker, malondialdehyde (MDA). It also increased the activity of superoxide dismutase (SOD) and the content of reduced glutathione (GSH). This study indicates that PP significantly decreased LPS-induced inflammation in the LPS-mediated ALI murine model, suggesting that it may become a significant preventive strategy for treating nonspecific inflammation of the lungs.

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“…The plant is used traditionally to treat warts, and it 44 has also been used as an emetic and cathartic and for the treatment 45 of fever (Gamble, 1923;Ugurlu and Secmen, 2008;Viegi et al, 46 2003). 47 In the course of our interest in isolating anti-inflammatory 48 compounds from natural resources (Abdallah et al, 2014) and 49 based on the anti-inflammatory activity of flavonoids, which 50 represent a major constituent in C. tinctoria, the current study was performed. The study aimed to isolate and identify the major (1 !…”

Section: Introductionmentioning

confidence: 99%