Anti-inflammatory activity of Tetragronula species from Indonesia

Abstract

Anti-inflammatory drugs inhibit inflammation, particularly those classified as nonsteroidal anti-inflammatory drugs (NSAIDs). Several studies have reported that propolis has both anti-ulcerogenic and anti-inflammatory effects. In this study, we investigated the bioactive compound and in vivo anti-inflammatory properties of both smooth and rough propolis from Tetragronula sp. To further identify anti-inflammatory markers in propolis, LC-MS/MS was used, and results were analyzed by Mass Lynx 4.1. Rough and smooth propolis of Tetragonula sp. were microcapsulated with maltodextrin and arabic gum. Propolis microcapsules at dose 25–200 mg/kg were applied for carrageenan-induced rat’s paw-inflammation model. Data were analyzed by one-way ANOVA and Kruskal–Wallis statistical tests. LC-MS/MS experiments identified seven anti-inflammatory compounds, including [6]-dehydrogingerdione, alpha-tocopherol succinate, adhyperforin, 6-epiangustifolin, deoxypodophyllotoxin, kurarinone, and xanthoxyletin. Our results indicated that smooth propolis at 50 mg/kg inhibited inflammation to the greatest extent, followed by rough propolis at a dose of 25 mg/kg. SPM and RPM with the dose of 25 mg/kg had inflammatory inhibition value of 62.24% and 58.12%, respectively, which is comparable with the value 70.26% of sodium diclofenac with the dose of 135 mg/kg. This study suggests that propolis has the potential candidate to develop as a non-steroid anti-inflammatory drug.

Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study

“…Our previous study has shown that Sulawesi propolis may perform an antifungal activity to Candida albicans, C. tropicalis, C. krusei, C. parapsilosis, C. glabrata, and Cryptococcus neoformans ( Pratami et al, 2020 , Sahlan et al, 2020 ). It also exhibits antioxidant and anti-inflammatory activity due to the high phenolic content ( Christina et al, 2018 , Pratami et al, 2018 , Sahlan et al, 2019 ). The pharmacological potency of Sulawesi propolis should be further explored.…”

Molecular interaction analysis of Sulawesi propolis compounds with SARS-CoV-2 main protease as preliminary study for COVID-19 drug discovery

“…Propolis compounds are diverse according to the region ( Alday et al, 2016 ). Beforehand, Sulawesi propolis compounds from North Luwu have been identified by several research ( Mahadewi et al, 2018 , Miyata et al, 2019 , 2020a Miyata et al, 2020b , Sahlan et al, 2019 ). Sulawesi propolis previously was known to be produced by Tetragonula aff.…”

“…Sulawesi propolis exhibits antifungal activity to Candida albicans, C. tropicalis, C. krusei, C. parapsilosis, C. glabrata and Cryptococcus neoformans ( Sahlan et al, 2020 ). Other study showed that Sulawesi propolis is potential to be developed as a non-steroid anti-inflammatory drug and antioxidant agent ( Christina et al, 2018 , Sahlan et al, 2019 ). These facts encourage us to do more investigations regarding the health benefits of Sulawesi propolis.…”

Optimizing Anti-inflammatory Activities of Arabica Coffee Ground (Coffea arabica L.) Nanoparticle Gel

“…Inflammation is an immune response against the invasion of foreign objects, tissue damage, or both (1,2). The causes of inflammation include mechanical trauma, microorganism, physical effects, and chemical substances (3). The symptoms of anti-inflammatory response consist of swelling (tumor), heat (calor), pain (dolor), and redness (rubor) that inflammatory mediators such as prostaglandin, histamine, leukotriene, and serotonin, are being released (3,4).…”