Anti-inflammatory, analgesic activity and acute toxicity of Glaucium grandiflorum extract

Morteza‐Semnani, Katayoun; Saeedi, Majid; Hamidian, Maliheh; Vafamehr, Hamid; Dehpour, Ahmad Reza

doi:10.1016/s0378-8741(02)00027-2

Cited by 26 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies on G. grandiflorum methanol extract showed significant anti-inflammatory and analgesic activity in the carrageenan, hot-plate and formalin tests (18). Also, another study on the methanol extracts and total alkaloids of G. paucilobum showed graded inhibition of both phases of formalin-induced pain.…”

Section: Discussionmentioning

confidence: 87%

Antinociceptive Effect of the Endemic Species Glaucium vitellinum Boiss and Buhse

Rangriz

Mousavi

Najafizadeh

et al. 2016

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

Background: Glaucium vitellinum is an endemic species and is extensively exploited as an anti-inflammatory agent in Iranian traditional medicine. Objectives: This study was designed to evaluate the antinociceptive activities of G. vitellinum methanol extract in male mice. Materials and Methods:The formalin and hot-plate methods were used for pain evaluation in mice. Glaucium vitellinum extract (50, 100, 200 and 400 mg/kg body weight IP), saline and morphine (2 mg/kg, IP) were administered 15 minutes prior to the formalin test. The nociceptive responses were divided to two phases; phase І (0 -15 minutes) and phase ІІ (15 -60 minutes) were compared to the control and morphine. In the hot-plate test, G. vitellinum extract (80, 160, 200 and 250 mg/kg IP), saline and morphine (5 mg/kg, IP) were administered and, behavioral responses were immediately tested, 15, 30, 45 and 60 minutes after the injection. Comparisons between the groups were carried out using the analysis of variance (ANOVA), and post hoc Tukey's test. Results: All doses of G. vitellinum extract induced anti-nociception activity during the first and second phases of the formalin test. The extract showed a significant (P < 0.05) dose-related inhibition during the first phase compared to the control group. In the second phase of the formalin test, the extract showed analgesic activity comparable to the effect of morphine. In pre-treatment with non-selective opioid receptor antagonist, naloxone could reverse the anti-nociceptive effect of the extract in the formalin test. In the hot-plate method, with the highest dose of 250 mg/kg, the anti-nociceptive activity of the studied extract was comparable to the standard drug, morphine. Conclusions: This study revealed that G. vitellinum extract possessed a significant anti-nociceptive activity in formalin pain models and hot-plate test in mice and might have a potent role against pain.

show abstract

Section: Discussionmentioning

confidence: 87%

Antinociceptive Effect of the Endemic Species Glaucium vitellinum Boiss and Buhse

Rangriz

Mousavi

Najafizadeh

et al. 2016

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

show abstract

“…Formalin produced a different biphasic response where analgesics may act differently in the first and second trial phases [47]. The first phase of the formalin model lasts a few minutes and begins immediately after the injection of formalin in the plantar surface of the animal and is due to release of the substance P and direct chemical stimulation of afferents, especially C fibers [48, 49].…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Activity of the Chloroform Fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in Mice

Mota

Carvalho

Morais

et al. 2011

BioMed Research International

View full text Add to dashboard Cite

Acute treatment with the chloroform fraction of Dioclea virgata (Rich.) Amshoff (CFDv) in mice produced decreased ambulation and sedation in the behavioral pharmacological screening. Doses of 125 and 250 mg/kg CFDv decreased latency of sleep onset in the test of sleeping time potentiation. In the open field, animals treated with CFDv reduced ambulation and rearing (250 mg/kg), as well as defecation (125; 250 mg/kg). Regarding the antinociceptive activity, CFDv (125, 250, 500 mg/kg) increased latency to first writhing and decreased the number of writhings induced by acetic acid. In the formalin test, CFDv (250 mg/kg) decreased paw licking time in the first and second phases indicating antinociceptive activity that can be mediated both peripherally and at the central level. CFDv did not affect motor coordination until 120 minutes after treatment. CFDv shows psychopharmacological effects suggestive of CNS-depressant drugs with promising antinociceptive activity.

show abstract

“…[13][14][15] The first phase results from direct chemical stimulation of the nociceptive afferent fibers, mainly C fibers, and may be inhibited by centrally acting analgesics such as morphine. The second phase results from the action of inflammatory mediators released locally, such as prostaglandins, serotonin, histamine, and bradykinin, and also from enhanced synaptic transmission in the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Effect of the Extract of Morus nigra Leaves in Mice

Padilha

Vilela

Silva

et al. 2009

Journal of Medicinal Food

View full text Add to dashboard Cite

Morus nigra has been used to relieve pain in Brazilian folk medicine. This study was conducted to establish the antinociceptive properties of dichloromethane extract from leaves of M. nigra. The formalin, hot plate, and tail immersion tests as well as acetic acid-induced writhing were used to investigate the antinociceptive activity in mice. The extract at test doses of 100 and 300 mg/kg, p.o. clearly demonstrated antinociceptive activity in all tests. The extract administered at 300 mg/kg, p.o. had a stronger antinociceptive effect than indomethacin (5 mg/kg, p.o.) and morphine (10 mg/kg, p.o.), which supports previous claims for its traditional use.

show abstract

Anti-inflammatory, analgesic activity and acute toxicity of Glaucium grandiflorum extract

Cited by 26 publications

References 17 publications

Antinociceptive Effect of the Endemic Species Glaucium vitellinum Boiss and Buhse

Antinociceptive Effect of the Endemic Species Glaucium vitellinum Boiss and Buhse

Antinociceptive Activity of the Chloroform Fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in Mice

Antinociceptive Effect of the Extract of Morus nigra Leaves in Mice

Contact Info

Product

Resources

About