Anti-inflammatory, analgesic and anti-lymphocytic activities of the aqueous extract of Crinum giganteum

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

“…Tannins also aid vasoconstriction, reducing vascular permeability and producing an anti-inflammatory action (Kapu et al, 2001;Mota et al, 1985). In addition, they have an antimicrobial effect (Schulz et al, 2002;Lopes et al, 2005).…”

“…This layer isolates the wound site from the environment, reducing the permeability and exudation of the wound (Brown, Dattner, 1998;Bedi, Shenefelt, 2002) and promoting tissue repair. Tannins also exhibit vasoconstrictor and anti-inflammatory properties (Mota et al, 1985;Kapu et al, 2001) and stimulate the growth of epidermis, aiding reepithelialization (Palermo et al, 2002;. Reepithelialization involves the proliferation and migration of cells from the edges of the wound, and is regulated by mechanisms involving genes, growth factors, integrins, extracellular matrices (ECM) and metalloproteinases (MMPs) (Santoro, Gaudino, 2005).…”

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“…The effects were comparable to aspirin. In addition, oral administration of the extract (200 mg/Kg) resulted in a marked dose-dependent antiinflammatory activity in cotton pellet-induced granuloma in rats 8 .…”

“…Their use extended from the ancient times to nowadays especially in Africa, tropical Asia and South America. Several Crinums are traditionally used as emetics, laxatives, expectorants, tonics, antipyretics, diuretics, diaphoretics, anti-asthmatics, anti-malarial, antiaging, anti-tumor and lactagogues [3][4][5][6][7][8][9][10] . In addition, they are commonly used in treatment of various painful and inflammatory disorders such as rheumatism, earache, lumbago, edema, headache, swelling, backache, wounds and haemorrhoids 3,5,[11][12][13] .…”

Phytochemical Screening and Oral Acute Toxicity Study of Aqueous Leaf Extract of Crinum giganteum (Gadalli) in Wister Rats

“…The plant is also known by other names in different ethnic groups across Africa (Keay 1989 (Keay, 1989). The bulb extract of C. giganteum has been found to possess alkaloids and tannins with intraperitoneal LD 50 of 627 ± 5.8 mg/kg and 520 ± 10.2 mg/kg in mice and rats, respectively and also oral LD 50 of 1486 ± 18.9 mg/kg and 1023 ± 4.3 mg/kg in mice and rats, respectively (Kapu et al, 2001). There is a paucity of information on the phytochemical agents and LD 50 of the aqueous leaf extract of C. giganteum despite the increasing rate of the consumption of the leaf and other parts of this plant as a …”