Anti-inflammatory, analgesic and antipyretic activities of <i>Physalis minima</i> Linn

Khan, Murad Ali; Khan, Haroon; Khan, Sarwar; Mahmood, T. A.; Khan, Pir Mohammad; Jabar, Abdul

doi:10.1080/14756360802321120

Cited by 68 publications

(42 citation statements)

References 18 publications

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“…Edema formation in rat paw due to carrageenan injection is a biphasic event of 1-5h; the initial phase of 1-1.5h is predominately a non-phagocytic edema followed by a second phase of 2-5h with increased formation of edema that may remain up to 5h. 22,23 The initial phase edema induction is due to the action of mediators such as serotonin, histamine and bradykinin on vascular permeability. 24 The late phase edema is the result of over production of prostaglandins.…”

Section: Discussionmentioning

confidence: 99%

Toxicity Assessment and Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Activities on Cordia obliqua Leaf Methanol Extract

Gupta¹,

Gupta²

2017

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Background: Cordia obliqua Willd. Plant belongs to genus Cordia and family Boraginaceae. Commonly it is known as Clammy Cherry and in Hindi Lasora. Earlier very few researches were carried out to explore its medicinal importance as compared with other Cordia species. Objective: To determine maximum safe dose and explore analgesic, anti-inflammatory and antipyretic activities of Cordia obliqua leaf methanol extract. Materials and Methods: As per our previous study report, the leaf methanol extract is rich in phyto-constituents and has good antioxidant effect; so only methanol extract was studied here. The maximum safe dose of methanol extract was found by acute oral toxicity study according to OECD guidelines 423. For analgesic effect, hot plate and tail flick method, for anti-inflammatory, Carageenan induced rat paw edema and for antipyretic study, yeast induced pyrexia method were used. Results: The extract dose up to 2000mg/Kg was found safe with no any side effects. Three dose levels were tested for all activities. The medium (250 mg/Kg) and high (500 mg/Kg) dose of methanol extract was found effective in all activities when compared with standard. The result for antipyretic activity was found better than other activities. Conclusion: It can be concluded that Cordia obliqua leaf is safe and effective drug for relief of pain, fever and inflammation.

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Section: Discussionmentioning

confidence: 99%

Toxicity Assessment and Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Activities on Cordia obliqua Leaf Methanol Extract

Gupta¹,

Gupta²

2017

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“…Anti-mutagens and radical scavengers (Kilani et al 2005), Antimalarial (Thebtaranonth et al 1995), Antidiarrheal (Uddin et al 2006b), Antibacterial activity (Nima et al 2008), Antioxidant activity (Nagulendran et al 2007), wound healing activity (Puratchikody et al 2006) 13 Physalis minima Urinary tract infection Earache, stomach pain, pain (Islam et al 2014), urinary track, diuretic, joint inflammation, blood purifier, skin disease, pimples, liver tonic (Parul and Vashistha 2015) Analgesic activity (Anand et al 2014), Diuretic activity Antiulcer Activity (Tammu et al 2013), CNS depressant activity (Dharamveer et al 2009), Antibacterial Potential , Antioxidant Activity (Gupta et al 2010), Antifertility (Sudhakaran et al 1999) (Devi et al 2012) 15 Cynodon dactylon Menstruation, milk yield enhancer Scanty, irregular periods (Yadav et al 2006), piles, irritation of urinary tract, vomiting, wounds (Khan et al 2013b) Antioxidant activity (Sies 1997), Anticancer activity (AlbertBaskar and Ignacimuthu 2010), Anticonvulsant activity (Pal 2009), Hypoglycemic activity , Immunomodulatory activity (Mangathayaru et al 2009), Hepatoprotective activity (Surendra et al...…”

Section: Syzygium Cuminimentioning

confidence: 99%

Connecting corporations and communities: Towards a theory of social inclusive open innovation

Gupta¹,

Dey

Singh

2017

Journal of Open Innovation: Technology, Market, and Complexity

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Despite pervasiveness of the market forces and supplementary role of the state and in some cases, even civil society organisations, there are unmet social needs which remain unaddressed by the existing institutions. With industrial growth becoming jobless, the need for new models of social innovation is being felt all around the world to provide jobs to the youth, skills for the new economy and entrepreneurial opportunities for transforming resources and skills. The persistence of some of these unmet needs (also referred as wicked problems sometimes) or unaddressed problems for a long time shows that the existing institutional arrangements are inadequate for the purpose. Innovations are imperative. A socio-ecological system that recognizes and rewards innovation can withstand many external shocks, provided it is agile and innovates quickly to remain responsive to emergent challenges (Anderies, Janssen, & Ostrom. Ecology and society, 9 (1)

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“…Carrageenan model of inflammation is also said to be biphasic. Generally, in the first phase, histamine, serotonin and kinnins are released and form nonphagocytic edema in the first hour while the second phase is attributed to the release of prostaglandins and lysosome enymes in the second to the third hour (Khan et al, 2009;Muhammad et al, 2012). The second phase is sensitive to most clinically effective anti-inflammatory drugs (Muhammad et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

Jain

Hossain²,

Fatema³

et al. 2014

American Journal of Pharmacology and Toxicology

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Allophylus cobbe L. Raeuschel (Family-Sapindaceae) is a medicinal plant used traditionally for the treatment of various health risks like pain, inflammation, ulcers and wounds in Bangladesh. This study determined the polyphenolic compounds and evaluated the analgesic, anti-inflammatory and antioxidant effects of the ethanol extract of Allophylus cobbe leaves. High Performance Liquid Chromatography (HPLC) analysis was used to determine the polyphenolic compounds present in the extract. The analgesic activity was evaluated by hot plate and acetic acid induced writhing in mice at two different doses of 250 and 500 mg kg −1 body weight. The extract was also investigated for the anti-inflammatory effect on rats at above mentioned doses using carrageenan induced rat paw edema method. The antioxidant potential of the extract was determined in terms of radical scavenging ability of the stable 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH) free radical. Preliminary phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins and glycosides in the extract. High Performance Liquid Chromatography (HPLC) analysis also confirmed the presence of polyphenolic compounds such as (+)-catechin hydrate, (-)-epicatechin, caffeic acid, p-coumaric acid and quercetin. The extract increased the licking time of hind paw when placed on a hot plate by 35.31% at 250 mg kg −1 dose which is comparable to the increase shown by diclofenac sodium (42.73%) at the 3rd h of study in hot plate test. Moreover, the extract also showed good analgesic effect in acetic acid induced writhing test. The percent inhibition of writhing response by the extract was 85.96 and 78.07% at 250 and 500 mg kg −1 doses respectively while that of the standard drug was 66.67%. Furthermore, the extract also reduced carrageenan induced paw edema formation; the most prominent inhibition was found to be 58.88% (250 mg kg −1 ) at the 3rd h of study. The DPPH radical scavenging activity of the extract increased markedly with increasing concentrations. At a concentration of 200 µg mL −1 , the scavenging activity of the ethanol extract (91.53% inhibition) was comparable to that of the standard ascorbic acid (99.3% inhibition). Our results suggest that Allophylus cobbe extract possesses significant antinociceptive, anti-inflammatory and free radical scavenging activities which may justify the folkloric use of the plant in several communities for conditions such as colic, fever, inflammatory rheumatic pains and other oxidative stress associated disorders.

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Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn

Cited by 68 publications

References 18 publications

Toxicity Assessment and Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Activities on Cordia obliqua Leaf Methanol Extract

Toxicity Assessment and Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Activities on Cordia obliqua Leaf Methanol Extract

Connecting corporations and communities: Towards a theory of social inclusive open innovation

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

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