Anti-inflammatory analgesics and drugs used in rheumatism and gout

Prescott, L. F.

doi:10.1016/s0378-6080(78)80013-0

Cited by 5 publications

(5 citation statements)

References 267 publications

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“…Headache is a common symptom, particularly during treatment with indomethacin, and it has been reported t o occur in 20 t o 60 per cent of the patients (1,19). This side-effect is not conspicuous after ibuprofen or naproxen (5, 10) nor is it common after administration of fenamates, but it can be seen in up t o 15 per cent of patients treated with tolmetin (4).…”

Section: Side-effects Common To the Whole Groupmentioning

confidence: 99%

“…Considering the fact that symptoms from the gastrointestinal tract and from the central Table IV. Rashes and other allergic manifestations can be serious complications of treatment with phenylbutazone and oxyphenbutazone ( 19). They are infrequent but occur also after indomethacin, aryl propionic acids, and fenamates (19).…”

Section: Side-effects Common To the Whole Groupmentioning

confidence: 99%

“…Rashes and other allergic manifestations can be serious complications of treatment with phenylbutazone and oxyphenbutazone ( 19). They are infrequent but occur also after indomethacin, aryl propionic acids, and fenamates (19). On the other hand the most frequent side-effect of the aryl acetic acid, alclofenac, is rashes (3,14).…”

Section: Side-effects Common To the Whole Groupmentioning

confidence: 99%

“…Phenylbutazone can probably damage the liver, even in therapeutic dosage and it has a potential nephrotoxic effect (19). Indomethacin, ibuprofen, and naproxen have been reported t o cause liver damage, but this action has seldom been serious.…”

Section: Side-effects Of Pgsi's 103mentioning

confidence: 99%

“…Fenamates seem to be potentially nephrotoxic and acute renal insufficiency has been observed after treatment with mefenamic acid (19).…”

Section: Side-effects Of Pgsi's 103mentioning

confidence: 99%

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Side‐effects of Prostaglandin Synthetase Inhibitors

Andersson

1979

Acta Obstet Gynecol Scand

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A short review is given of some of the adverse reactions to prostaglandin synthetase inhibitors. Broadly, these sideeffects can be divided into those common to the whole group, and those more or less characteristic of the individual drugs. Among the former, symptoms from the gastrointestinal tract and from the central nervous system are the most conspicuous. Skin reactions, bronchospasm, and serious blood dyscrasias have been reported for several of these drugs and the list of more rare sideeffects is long. It is concluded that drugs like phenylbutazone and oxyphenbutazone should not be used for treatment of dysmenorrhea because of the risks of serious adverse reactions. However, even if among the newly introduced compounds none can be said to be free from risks, some seem to have an acceptable ratio between therapeutic efficacy and sideeffects.

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Section: Side-effects Common To the Whole Groupmentioning

confidence: 99%

Section: Side-effects Common To the Whole Groupmentioning

confidence: 99%