Side‐effects of Prostaglandin Synthetase Inhibitors

Abstract

A short review is given of some of the adverse reactions to prostaglandin synthetase inhibitors. Broadly, these sideeffects can be divided into those common to the whole group, and those more or less characteristic of the individual drugs. Among the former, symptoms from the gastrointestinal tract and from the central nervous system are the most conspicuous. Skin reactions, bronchospasm, and serious blood dyscrasias have been reported for several of these drugs and the list of more rare sideeffects is long. It is concluded that drugs like phenylbutazone and oxyphenbutazone should not be used for treatment of dysmenorrhea because of the risks of serious adverse reactions. However, even if among the newly introduced compounds none can be said to be free from risks, some seem to have an acceptable ratio between therapeutic efficacy and sideeffects.

Molecular aspects of development and regulation of endometriosis

“…PGSIs are effective in the early stages of endometriosis, but lose efficacy when symptoms become more severe [212]. Nevertheless a lot of side effects such as skin reactions, bronchospasm, and serious blood dyscrasias have been reported for several of these drugs [213]. …”

Endometriosis diagnosis and medical treatment: Present and future

“…PGSIs are effective in the early stages of endometriosis, but lose efficacy when symptoms become more severe (130). Nevertheless, a lot of side effects such as skin reactions, bronchospasm, and serious blood dyscrasias have been reported for several of these drugs (131).…”

“…The most common side effects of OCP treatment are acne, weight gain, and irregular withdrawal bleeding. The continuous use of oral contraceptives has been found to increase the risk of thromboembolism in some patients, for example, smokers aged more than 35 years or those who have a history of cardiovascular disease, and women trying to conceive (131).…”