Anti-Inflammatory and Analgesic Activities of Topical Formulations of Pterocarpus Santalinus Powder in Rat Model of Chronic Inflammation

Dhande, Priti; Gupta, Amit O; Jain, Sourav; Dawane, Jayshree

doi:10.7860/jcdr/2017/25081.10257

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…Anti-inflammatory effect may be due to savinin, a lignan, which inhibited inflammatory markers such as tumor necrosis factor-α (TNF-α) and T-cell proliferation. P. santalinus gel was effective in chronic inflammation and could be used in arthritis-like conditions [18].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Phytochemistry and Pharmacology of Pterocarpus Santalinus and Its Role in Dermatology

Kuchekar¹,

Navghare

Kulkarni³

et al. 2021

Asian J Pharm Clin Res

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The review provides an updated overview of the phytochemical and pharmacological studies on Pterocarpus santalinus. It briefs on the synergistic interactions of P. santalinus with other medicinal plants and its use in Ayurvedic formulations. Phytochemical analysis suggests the presence of triterpenoids, steroids, flavonoids, and phenolic acids. The phytoconstituents and related pharmacological activities of various parts of P. santalinus include antifungal, anticholinesterase, antidiabetic, antibacterial, antipyretic, anti-inflammatory, anticancer, and antiulcer. Literature survey highlights the dermatological applications of the phytoconstituents such as pterostilbene, savinin, and betulin as potential leads for anti-aging, ultraviolet rays (UV-B) protective, and wound healing effects. Undoubtedly, P. santalinus has wide therapeutic value. The dermatologically significant phytoconstituents, namely, pterostilbene, cedrol, savinin, lupeol, betulin, β-eudesmol, and α-bisabolol, if isolated and used in dermatological formulations, can show promising skin protective effect. The data were compiled using scientific databases, namely, Google Scholar and PubMed, the data made available specifically from 2010 to 2021.

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Section: Antibacterial Activitymentioning

confidence: 99%

Phytochemistry and Pharmacology of Pterocarpus Santalinus and Its Role in Dermatology

Kuchekar¹,

Navghare

Kulkarni³

et al. 2021

Asian J Pharm Clin Res

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“…Pancreatic lipase and α-amylase inhibition [100]; anti-urease activity [101] Heartwood of Pterocarpus santalinus (Red sanders) India and Korea; Inflammation, mental aberrations, cancer and ulcer [102,103] Antioxidant properties; anti-microbial [104] and anti-inflammatory activities [103,105].…”

Section: Herbs Of Potentilla Aurea (Goldfinger Herb)mentioning

confidence: 99%

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

et al. 2020

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Twenty natural remedies traditionally used against different inflammatory diseases were probed for their potential to suppress the expression of the inflammatory markers E-selectin and VCAM-1 in a model system of IL-1 stimulated human umbilical vein endothelial cells (HUVEC). One third of the tested extracts showed in vitro inhibitory effects comparable to the positive control oxozeaenol, an inhibitor of TAK1. Among them, the extract derived from the roots and rhizomes of Peucedanum ostruthium (i.e., Radix Imperatoriae), also known as masterwort, showed a pronounced and dose-dependent inhibitory effect. Reporter gene analysis demonstrated that inhibition takes place on the transcriptional level and involves the transcription factor NF-κB. A more detailed analysis revealed that the P. ostruthium extract (PO) affected the phosphorylation, degradation, and resynthesis of IκBα, the activation of IKKs, and the nuclear translocation of the NF-κB subunit RelA. Strikingly, early effects on this pathway were less affected as compared to later ones, suggesting that PO may act on mechanism(s) that are downstream of nuclear translocation. As the majority of cognate NF-κB inhibitors affect upstream events such as IKK2, these findings could indicate the existence of targetable signaling events at later stages of NF-κB activation.

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“…over 180million people affected by it. 11 It is associated with joint inflammation with immune cell infiltration, pain, swelling and synovial hyperplasia. Chronic inflammation leads to joint deformity and compromises the activities of daily living.…”

Section: Introductionmentioning

confidence: 99%

A pilot clinical study to manifest theefficacy of Pankajakasthuri orthoherb cream/thermagel in the treatment of patients diagnosed with osteoarthritis

Sasidharan¹,

J²,

GS³

et al. 2022

IJCAM

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Osteoarthritis (OA) is a major form of arthritis associated with severe joint pain that reduces the quality of life. Various pharmacological interventions may be utilized for arthritis treatment when non-pharmacological therapy is insufficient. However, pharmacological treatment can have serious side effects and high costs. Therefore, alternative therapies have been under investigation to manage this condition. Medicinal plants and their secondary metabolites are significant as alternative treatments available for inflammatory diseases. In the current study, we investigated the efficacy of Pankajakasthuri orthoherb cream/thermagel in managing OA. A total of thirty patients over 18 years of age diagnosed with osteoarthritis were enrolled from July 1 st , 2021 to August 31 st , 2021 for the clinical trial. All subjects were applied with Pankajakasthuri Orthoherb cream/thermagel 1gm (pea size) at a time, externally, thrice daily with an interval of 6 hours. The following clinical parameters, viz. pain, swelling, stiffness, tenderness, pain on movement, were used for evaluating the effect of Pankajakasthuri Orthoherb cream/thermagel in managing osteoarthritis conditions. The intervention was continued for one month and assessments were done before treatment and on the 10 th , 20 th and 30 th days after treatment. The study results showed that Pankajakasthuri orthoherb cream/thermagel recorded significant improvement in the clinical condition associated with osteoarthritis within 30 days of intervention when analyzed using t-test. This clinical study proved that Pankajakasthuri orthoherb cream/thermagel is highly effective in managing the clinical conditions associated with osteoarthritis.

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Anti-Inflammatory and Analgesic Activities of Topical Formulations of Pterocarpus Santalinus Powder in Rat Model of Chronic Inflammation

Cited by 5 publications

References 14 publications

Phytochemistry and Pharmacology of Pterocarpus Santalinus and Its Role in Dermatology

Phytochemistry and Pharmacology of Pterocarpus Santalinus and Its Role in Dermatology

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-κB Signaling

A pilot clinical study to manifest theefficacy of Pankajakasthuri orthoherb cream/thermagel in the treatment of patients diagnosed with osteoarthritis

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