Anti-Inflammatory and Analgesic Activities of &lt;i&gt;Nothospondias staudtii&lt;/i&gt;

Owoyele, Bamidele Victor; Olaleye, Samuel Babafemi; Oke, JM; Elegbe, R.A.

doi:10.4314/njps.v19i1.32644

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…This was repeated every thirty minutes for 2 hours. The reaction time was taken as the time for the rats to remove their tail from the hot water in the water bath (Owoleye et al, 2004). The % inhibition in both cases was calculated using the following formula:…”

Section: Tail Immersion Testmentioning

confidence: 99%

Antinociceptive Effect of the Ethanol Leaf Extract of <i>Balanites aegyptiaca</i> Linn in Albino Rats

Sodipo¹,

Yakubu²,

Dungus³

et al. 2020

Nig J Bas App Sci

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Balanites aegyptiaca is a medicinal plant that has been used in a variety of folk medicines in India and Africa for the treatment of different ailments such as syphilis, jaundice, liver and spleen problems, epilepsy, yellow fever. This research aimed at investigating the phyt ochemical constituents, acute toxicity, anti inflammatory and antinociceptive activities of the ethanol extract of Balanites aegyptiaca (EEBA) leaves. The plant material was extracted using ethanol as solvent. The dried ethanol extract was screened for the presence of phytochemicals; Acute toxicity (LD50) was determined using Lorke’s method while anti inflammatory and antinociceptive activities were evaluated using hot plate and tail immersion methods in albino rats. Results of the study revealed that phyto chemical constituents such as flavonoids, carbohydrates, saponins and glycosides were found in the EEBA, intraperitoneal LD 50 of 2154 mg/kg shows the substance is non toxic. The EEBA produced significant (p <0.05) and dose dependent anti inflammatory and a ntinociceptive activities at all test doses (200, 400 and 600 mg/kg). The presence of the phytochemicals detected might be responsible for the demonstrated anti inflammatory and antinociceptive activities in the plant extract. Keywords: Phytochemical, Anti inflammatory, Antinociceptive , Balanites aegyptiaca

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Section: Tail Immersion Testmentioning

confidence: 99%

Antinociceptive Effect of the Ethanol Leaf Extract of <i>Balanites aegyptiaca</i> Linn in Albino Rats

Sodipo¹,

Yakubu²,

Dungus³

et al. 2020

Nig J Bas App Sci

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show abstract

“…The time period in which tail flicked out from water bath was recorded. The observations were made for 180 min at every 30 min interval (Owoyele et al, 2004). The reaction time was determined at 30, 60, 90, 120,150 and 180 min after treatment.…”

Section: Tail Flick Testmentioning

confidence: 99%

Anti-nociceptive and anti-inflammatory activities of Holoptelea intrigofolia (Roxb.) planch fruit extract on laboratory animals

Zahid¹,

Rizwani²,

Zahid³

2015

Afr. J. Pharm. Pharmacol.

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The methanolic extract of the fruit of Holoptelea integrifolia (Roxb) Planch was investigated for its antiinflammatory and analgesic activities in animal models. The extract at 100, 150 and 200 mg/kg body weight reduced significantly the formation of edema induced by carrageenan. In the acetic acid-induced writhing model, the extract showed a good analgesic effect characterized by reduction in the number of writhes when compared to the control. The analgesic effect of extract of H. integrifolia was also significant (P < 0.05) in tail immersion test and was dose dependent. These results were also comparable to those of diclofenac sodium (50 mg/kg), the reference drugs used in this study. Though the study has provided some justification for the folkloric use of the plant in several communities for conditions such as pain and inflammations but caution should be exercised in its use for medicinal purpose.

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“…(Junping, 2005) After the determination of baseline response latencies, hot-plate latencies were re-determined at 30min, 60min, and 90min after oral administration of tested drugs and positive-control in this experiment. The pain inhibition percentage was calculated (Wu et al, 2003;Owoyele, 2004) according to the following formula. % of (PIP) = Latency (test) -Latency (control) ×100)/Latency (control).…”

Section: Experimental Animalsmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models

Panda¹,

Panda²,

Panda³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMERYThe present study was carried out to elucidate the potential of, chloroform extract of Pandanus (P.) fascicularis Lamk (Family-Pandanaceae) leaves on antinociceptive, behavioral study and antiinflammatory effects using various animal models The dried, powdered leaves of, P. fascicularis were extracted successively with petroleum ether (60 -80°C) and chloroform in soxhlet apparatus. The chloroform extract (yield 21.6% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Two models were employed to investigate the effects on nociception, the tail immersion and hot plate method in Swiss albino mice and anti inflammatory effect were investigated by employing the carrageenan induced rat paw edema test in. adult Wister albino rats. Behavioral study was investigated by elevated plus maze method in Swiss albino mice. Results were revealed that the PFCE was found significant antinociceptive effect (P < 0.001) at the dose levels of 100, 200 and 400 mg/kg, orally in mice and produced remarkable antiinflammatory effect (P < 0.001) at the same dose levels used in the rats. Behavioral study of the PFCE has no significant anxiolysis effect when used orally. It concludes that, PFCE possessed remarkable antinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.

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Anti-Inflammatory and Analgesic Activities of <i>Nothospondias staudtii</i>

Cited by 9 publications

References 6 publications

Antinociceptive Effect of the Ethanol Leaf Extract of <i>Balanites aegyptiaca</i> Linn in Albino Rats

Antinociceptive Effect of the Ethanol Leaf Extract of <i>Balanites aegyptiaca</i> Linn in Albino Rats

Anti-nociceptive and anti-inflammatory activities of Holoptelea intrigofolia (Roxb.) planch fruit extract on laboratory animals

Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models

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