Anti-inflammatory and analgesic activity of the topical preparation of Glaucium grandiflorum

Morteza‐Semnani, Katayoun; Saeedi, Majid; Hamidian, Maliheh

doi:10.1016/j.fitote.2003.12.007

Cited by 35 publications

(13 citation statements)

References 10 publications

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“…The formalin test was performed according to the method described by Morteza-Semnani et al (2004). 0.3 g of cream containing 0.1-0.5% of kirenol were applied to the dorsal surface of the left hind paw by gently rubbing 50 times with the index finger.…”

Section: Formalin Testmentioning

confidence: 99%

Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis

Wang

Zhou

et al. 2011

Journal of Ethnopharmacology

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Section: Formalin Testmentioning

confidence: 99%

Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis

Wang

Zhou

et al. 2011

Journal of Ethnopharmacology

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“…However, only limited numbers of studies have been conducted to elucidate the action mechanisms of these products on inflammatory diseases [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Rutin and Quercetin Flavonoids in Glaucium corniculatum Methanol and Water Extracts

Koçanci¹,

Aslım²

2017

International Journal of Secondary Metabolite

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Neurodegenerative diseases (NDs) are characterized by loss of neurons. NDs are associated with development of inflammation. Existing drugs against NDs only delay the progression; however, they do not provide a cure. The studies for the treatment of NDs focused on to discover natural products that have the potential of anti-inhibition and anti-radical properties. The Papaveraceae family members are important for the synthesis of pharmaceutically compounds such as flavonoids which act like anti-inflammatory drugs. In this study, methanol and water extracts of Glaucium corniculatum, a member of the Papaveraceae family, were analysed for flavonoid compounds. The effects of extracts on neuronal PC12 cells viability was determined. The anti-inflammatory effects of extracts were assessed by measuring the levels of IL-6 and IL-10 cytokines on hydrogen peroxide (H2O2)-stimulated PC12 cells. As a result of our studies, Rutin and Quercetin flavonoids have been found to be as major. The amount of Rutin was higher in methanol (45 μg/ml) than water (41 μg/ml). Quercetin was better extracted with methanol (12 μg/ml) than water (10 μg/ml). None of the tested extracts were cytotoxic even to PC12 cells. Both extracts showed an anti-inflammatory effect in a dose dependent manner. The water extract showed the maximum anti-inflammatory effect, with IL-6 secretion decreased 79 fold according to the H2O2 treated group and IL-10 secretion increased to 87 fold according to the control group. This study is an evidence that the Rutin and Quercetin flavonoids detected in G. corniculatum methanol and water extracts have a neuroprotective effect through anti-inflammation.

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“…Earlier research suggests that the beneficial role of herbal medicine and natural products in various disease conditions is due to synergy of chemicals present in it (Wagner and -Merzenich, 2009;Morteza-Semnani et al, 2004). MC used in the present study was a mixture of momordicosides K and L, and momordicines I and II along with GA, which might have pharmacological actions.…”

Section: Effect Of Standardized MC Compared With Its Marker Compound mentioning

confidence: 94%

Standardized fruit extract of Momordica charantia L protect against vincristine induced neuropathic pain in rats by modulating GABAergic action, antimitotoxic, NOS inhibition, anti-inflammatory and antioxidative activity

Jain

Pareek

Ratan

et al. 2015

South African Journal of Botany

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In the present experimental work, we investigate the protective potential of standardized Momordica charantia L fruit extract [gallic acid (GA) 6%; N8% bitters {momordicosides K (3%) and L (2%); and momordicines I (2%) and II (3%)}] (MC) comparable to its marker compound gallic acid in chemo-toxic neuropathy induced by vincristine [75 μg/kg intra-peritoneal (i.p.) for 10 consecutive days] in rats. An array of behavioral examinations was carried out on days 1st, 12th and 21st, followed by various biochemical and histopathological studies at the end. Vincristine significantly induced cold and dynamic mechanical allodynia, mechanical and heat hyperalgesia; functional deficit in walking and a rise in the levels of TNF-α, IL 6, mitochondrial complexes, myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), and nitrite along with decrease in glutathione (GSH). Administration of MC [400 and 800 mg/kg, per oral (p.o.)], GA (30 mg/kg, p.o.) and gabapentin (100 mg/kg, p.o.) attenuated the vincristine induced behavioral and biochemical changes. MC demonstrated superior antinociceptive activity in comparison to GA. Histopathological evaluation also divulged defending the effects of MC. Pretreatment of saclofen (1 mg/kg, i.p.), picrotoxin (1 mg/kg, i.p.) upturned the antinociceptive action of MC, but ingestion of GABA (100 mg/kg, i.p.) potentiated the action of MC. Additionally, pretreatment with L-arginine [nitric oxide (NO) donor; 100 mg/kg, i.p.] inverted the antinociceptive action of MC; whereas, aminoguanidine (iNOS inhibitor) and 7-nitroindazole (nNOS inhibitor) potentiated it. Besides this a PPARγ antagonist BADGE did not amend the effect of MC. Corroboratively, the attenuating effect of MC in vincristine induced neuropathy is attributed to its modulating action on GABAergic system along with antimitotoxic, NOS inhibition, anti-inflammatory and anti oxidative activities.

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Anti-inflammatory and analgesic activity of the topical preparation of Glaucium grandiflorum

Cited by 35 publications

References 10 publications

Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis

Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis

Neuroprotective Effects of Rutin and Quercetin Flavonoids in Glaucium corniculatum Methanol and Water Extracts

Standardized fruit extract of Momordica charantia L protect against vincristine induced neuropathic pain in rats by modulating GABAergic action, antimitotoxic, NOS inhibition, anti-inflammatory and antioxidative activity

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