Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice

Chao, Pei-Chun; Hsu, Cheng‐Chin; Yin, Mei‐chin

doi:10.1186/1743-7075-6-33

Cited by 222 publications

(173 citation statements)

References 28 publications

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“…The E. foetidum leaf extract contains kaempferol, chlorogenic acid, caffeic acid, lutein, and β-carotene. All components have been previously reported to have anti-inflammatory activities, and some also have antioxidant activities (Ching et al, 2002;Lee et al, 2004;Shin et al, 2004;Bai et al, 2005;Kowalski et al, 2005;dos Santos et al, 2006;Hamalainen et al, 2007;Chao et al, 2009;Shan et al, 2009;Zhang et al, 2010). Several bioactive compounds in E. foetidum leaves were recently reported (Paul et al, 2010) to play a role in anti-inflammatory and antioxidant activities.…”

Section: Discussionmentioning

confidence: 97%

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora

Muangnoi²,

Chingsuwanrote

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 97%

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora

Muangnoi²,

Chingsuwanrote

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Moreover, caffeic acid and ellagic acid (phenolic acids), which exist naturally in many plants, such as carrot, tomato, strawberry, and blueberry, can significantly inhibit the mRNA expression of inflammatory cytokines (including IL-6, TNF-α, and IL-1β) in diabetic mice (44). The aquatic extract of stevia (eg, stevioside) and metformin could reduce the level of IL-6.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

et al. 2017

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Background: Diabetes, as a common chronic disorder, is the seventh leading cause of death in the world. This disorder is classified into two major types: type I and type II diabetes mellitus. Recently, researchers have identified a higher level of inflammatory cytokines in patients with type II diabetes, compared to the normal population. Today, plant-based therapies, given their anti-diabetic properties, have attracted the researchers' attention. One of the medicinal plants with anti-diabetic effects is Stevia rebaudiana Bertoni. Various hypotheses have been proposed to explain how stevioside, as a derivative of Stevia rebaudiana, can cause such a significant decline in blood glucose level. To the best of our knowledge, the exact anti-inflammatory and immunomodulatory effects of the aquatic extract of stevia are not fully understood. Therefore, the current research aimed to evaluate whether stevia can improve the interleukin-6 (IL-6) level in streptozotocin-nicotinamide-induced diabetic rats. Methods:In the present study, a cohort of rats was divided into five groups, each containing 11 rats: (1) normoglycemic group, receiving 1 mL of water; (2) diabetic control group, receiving 1 mL of water; (3) and (4) diabetic groups treated with the aquatic extracts of stevia (400 mg/kg) and metformin (500 mg/kg), respectively; and (5) healthy group treated with the aquatic extract of stevia (400 mg/kg). At the end of the experiment, the rats were sacrificed and blood samples were collected from the heart for evaluating serum IL-6 changes. Statistical analysis was performed, using one-way analysis of variance (ANOVA), followed by the least significant difference (LSD) post-hoc multiple comparison test. Results:The present results showed that IL-6 (P = 0.001) and fasting blood sugar (FBS) (P < 0.001) levels significantly increased in all diabetic groups, compared to healthy rats. Surprisingly, treatment with stevia could significantly reduce FBS (P < 0.001), as well as IL-6 level (P = 0.001) in comparison with the diabetic group.Conclusions: Based on the findings, inflammation can be ameliorated with the whole aquatic extract of stevia, as an anti-diabetic compound. Therefore, by considering IL-6 level as an indicator of insulin resistance, stevia can lead to a decline in IL-6 level and thereby reduce insulin resistance in diabetic patients.

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“…Over the last few years, a number of in vivo and in vitro studies have provided evidence of important pharmacological properties including antioxidant, anti-inflammatory [7,8,9,10,11] and anticarcinogenic activities [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Rosillo

Sánchéz-Hidalgo

Cárdeno

et al. 2011

Biochemical Pharmacology

153

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 37A c c e p t e d M a n u s c r i p t

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Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice

Abstract: Background: Caffeic acid (CA) and ellagic acid (EA) are phenolic acids naturally occurring in many plant foods. Cardiac protective effects of these compounds against dyslipidemia, hypercoagulability, oxidative stress and inflammation in diabetic mice were examined.

Cited by 222 publications

References 28 publications

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Effect of the Aquatic Extract of Stevia on the Serum Level of Interleukin-6 in Streptozotocin-Nicotinamide Induced Diabetic Rats

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

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