Anti-inflammatory and anti-ulcer properties of hypolaetin-8-glucoside, a novel plant flavonoid

Villar, A.; Gasco, Manuel; Alcaraz, M. J.

doi:10.1111/j.2042-7158.1984.tb04884.x

Cited by 84 publications

(52 citation statements)

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“…through oral route. The flavonoids are also known as a naturally occurring compounds having gastroprotective effect (Villar et al, 1984 andAlarcon et al, 1994). Several mechanisms have been proposed to explain their biological effects; including increase of mucosal prostaglandin content, decrease of histamine secretion from mast cells, inhibition of acid secretion and inhibition of Helicobacter pylori growth.…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots

Chellappan¹,

Joseph²,

Balasubramanian³

2011

Rev. bras. farmacogn.

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Cyclea peltata Hook. f. & Thomson, belongs to the family Menispermaceae commonly known as "paatha", is a climbing shrub found throughout South and East India. In Indian traditional medicine the tuberous roots are also used to treat jaundice, stomachache, fever and asthma. This study deals with the microscopic study of leafs and roots of C. peltata, along with the physico-chemical, preliminary phytochemical analyses and antioxidant properties. Acute oral toxicity study was conducted as per OECD-423 guidelines and the extract was found to be devoid of any conspicuous acute toxicity in extract treated animals and no mortality upto 2 g/kg by oral route. Hydroalcoholic extract of C. peltata in a dose dependant manner (125 and 250 mg/kg. p.o.) showed significant gastric protection against the ethanol-induced gastric ulcer model in rats.

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Section: Discussionmentioning

confidence: 99%

Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots

Chellappan¹,

Joseph²,

Balasubramanian³

2011

Rev. bras. farmacogn.

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“…Flavonoids exert anti-proliferative and anti-inflammatory properties (4)(5)(6). Apigenin (4,5,7-trihydroxyflavone) is a non-toxic and non-mutagenic flavone that exists abundantly in numerous herbs and vegetables, including chamomile, thyme, parsley and broccoli, and displays cytostatic and cytoprotective activity (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Apigenin protects against bleomycin-induced lung fibrosis in rats

Chen

Zhao

2015

Experimental and Therapeutic Medicine

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Abstract. Apigenin is a non-toxic and non-mutagenic flavone that exists abundantly in numerous herbs and vegetables. Apigenin exerts anti-proliferative and anti-inflammatory properties. The aim of the present study was to investigate the effects of apigenin on bleomycin-induced lung fibrosis in rats. A single intratracheal instillation of bleomycin (5 mg/kg) was administered and rats were sacrificed on 7 and 28 days post bleomycin instillation. The instillation of bleomycin resulted in decreased body weight and an increase in the lung index. In addition, bleomycin administration increased the hydroxyproline content, myeloperoxidase (MPO) activity, tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β levels and decreased the superoxide dismutase (SOD) activity in the rat lung tissues. Excessive collagen deposits were detected in the lung tissues in bleomycin-treated rats compared with normal control rats. Notably, the oral administration of apigenin (10, 15 and 20 mg/kg/day) appeared to prevent the fibrotic process. The treatment suppressed the increases in hydroxyproline content, MPO activity, TNF-α and TGF-β levels and attenuated the reduction of SOD activity that were induced by bleomycin. Furthermore, excessive collagen deposition was inhibited by the apigenin treatment. Collectively, these results suggest that apigenin may function as a potent anti-inflammatory and anti-fibrotic agent against bleomycin-induced lung fibrosis.

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“…Various flavonoids and terpenoids have been isolated from this genus. 1,2) We have recently reported the anti-inflammatory properties of a lipid fraction obtained from Sideritis javalambrensis and those of the diterpenoid (ent-13(16),14-labdadiene-6a,8a,18triol-andalusol-) isolated from the acetone extract of Sideritis foetens, an endemic plant of Southern Spain. 3,4,5) Inflammation is normally a localized protective response which serves to destroy, dilute, or wall-off both the injurious agent and the injured tissue.…”

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confidence: 99%

Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens Clem.

Navarro

Heras

Villar

2001

Biological & Pharmaceutical Bulletin

129

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Interest in the phytochemical study of species of the Sideritis genus (Lamiaceae) has been stimulated by their pharmacological activity and their wide range of medicinal folk uses in Spain such as vulnerary, anti-infectious, anti-inflammatory, anti-rheumatic and anti-ulcerous applications. Various flavonoids and terpenoids have been isolated from this genus. 1,2) We have recently reported the anti-inflammatory properties of a lipid fraction obtained from Sideritis javalambrensis and those of the diterpenoid (ent-13(16),14-labdadiene-6a,8a,18triol-andalusol-) isolated from the acetone extract of Sideritis foetens, an endemic plant of Southern Spain. 3,4,5) Inflammation is normally a localized protective response which serves to destroy, dilute, or wall-off both the injurious agent and the injured tissue. The inflammatory response is coordinated by cells such as macrophages, lymphocytes, leukocytes and mast cells. A large number of mediators produced by these cells play a key role, for example, arachidonic acid metabolites such as prostaglandins and leukotrienes, reactive oxygen species, hydrolytic enzymes, histamine, nitric oxide, cytokines, etc. [6][7][8] Acute inflammation is associated with a rapid, early infiltration of polymorphonuclear leukocytes and increased vascular permeability at the site of injury.In this paper, we have evaluated the in vivo anti-inflammatory properties of a sterol fraction obtained from S. foetens on different inflammatory responses in mice. In addition, the interaction of this fraction with the functional properties of leukocytes and mast cells was analyzed in vitro. Immunomodulating activity through interaction with complement activation was also investigated. MATERIALS AND METHODS Plant MaterialThe aerial parts of Sideritis foetens were collected in Sierra de Gádor, Almería province (Spain). A voucher specimen has been deposited in the Department of Botany, Faculty of Pharmacy, Complutense University, Madrid (Spain). Extraction and IdentificationThe carrageenan-induced mouse paw oedema model was used for a bioassay guidedfractionation based on the anti-inflammatory activity.Dried aerial parts of Sideritis foetens (3 kg) were macerated with 99.5% acetone (12 l) at room temperature. The acetone extract was evaporated in vacuo to yield 84.8 g of residue. This extract (11.8 g) was fractionated by flash column chromatography over a silica gel (450 g, 230-400 mesh) column (6ϫ80 cm) using cyclohexane: acetone 70/30 to yield nine fractions. The most active fraction (subfraction B) (1.5 g) was chromatographed over a silica gel column (80 g, 230-400 mesh) using cyclohexane/ethyl acetate 70/30 as solvent, yielding the sterol fraction as white needles (800 mg).Sterol identification was performed by GC analysis [Perkin Elmer Sigma 3B equipped with a SE-30 Sobrechromosob WHP 3/100 column (lenght 2 m, i.d. 0.32 mm). Experimental conditions were: injector temp., 295°C; oven temp., 270°C (isotherm); detection temp., 285°C)]. The relative retention times were compared to standard samples. Campester...

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Anti-inflammatory and anti-ulcer properties of hypolaetin-8-glucoside, a novel plant flavonoid

Cited by 84 publications

References 10 publications

Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots

Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots

Apigenin protects against bleomycin-induced lung fibrosis in rats

Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens Clem.

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