Anti-inflammatory and anti-ulcerogenic properties of Stachytarpheta cayennensis (L.C. Rich) Vahl

Penido, Carmen; Costa, Karina A.; Futuro, D.O.; Paiva, Selma Ribeiro de; Kaplan, Maria Auxiliadora Coelho; Figueiredo, Maria Raquel; Henriques, Maria das Graças

doi:10.1016/j.jep.2005.09.006

Cited by 47 publications

(29 citation statements)

References 26 publications

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“…Moreover, compound 121 was found to be active in a carrageenan-induced hind paw edema model and in p-benzoquinone-induced writhing in mice [83]. Penido et al, revealed that 121 exhibited a potent inhibitory effect on LPS-induced total leucocyte, neutrophil and eosinophil accumulation in the pelural cavity along with a potent antiulcerogenic activity against diclofenac-induced gastric ulcers at 100 mg/kg [84]. Meanwhile, the histological scores indicated that treatment with 121 ameliorated intestinal inflammation in both acute and chronic dextran sulphate sodium-induced colitis in vivo through inhibition of oxidative burst activity [85].…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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Phenylethanoid glycosides (PhGs) are widely distributed in traditional Chinese medicines as well as in other medicinal plants, and they were characterized by a phenethyl alcohol (C 6 -C 2 ) moiety attached to a β-glucopyranose/β-allopyranose via a glycosidic bond. The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research. This review summarizes new findings on PhGs over the past 10 years, concerning the new structures, their bioactivities, including neuroprotective, anti-inflammatory, antioxidant, antibacterial and antivirus, cytotoxic, immunomodulatory, and enzyme inhibitory effects, and pharmacokinetic properties.

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Section: Anti-inflammatory Effectmentioning

confidence: 99%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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“…Vahl, Verbenaceae, is an herbaceous plant, popularly known as "gervão-roxo". Its leaves and roots are used in folk medicine in Brazil and other countries encompassing the Amazon rainforest to treat inflammation, varicose ulcers, fever, hepatic and renal disorders, hypertension and diabetes (Penido et al, 2006;Schapoval et al, 1998). Recently the anti-inflammatory, antinociceptive, gastroprotective and Leishmanicidal properties of ethanolic extracts were assessed (Moreira et al, 2007;Penido et al, 2006;Schapoval et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimicrobial, antioxidant and phototoxic activities of extracts and isolated compounds from Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae

Souza¹,

Silva²,

Machado³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Avalição da atividade antimicrobiana, antioxidante e fototóxica dos extratos e compostos isolados de Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae". Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, é uma planta utilizada na medicina popular brasileira contra úlceras e lesões de pele. Internamente é usada contra inflamações, febre, doenças renais e aterosclerose. Essa planta foi estudada com o objetivo de identificar os compostos bioativos majoritários que possam justificar seu uso terapêutico contra lesões de pele e arteriosclerose. A atividade antioxidante do extrato bruto etanólico, partições e os compostos majoritários isolados das raízes de S. cayennesis foi avaliada através de testes in vivo e in vitro. In vitro a atividade antioxidante foi avaliada pelo teste fotocolorimétrico do radical 2,2-difenil-1-picrilidrazil (DPPH•). In vivo, Saccharomyces cerevisiae, um modelo de célula eucariótica, foi utilizado tanto para avaliar a fototoxicidade quanto a capacidade antioxidante contra as espécies reativas de oxigênio (EROS) menadiona e peróxido de hidrogênio. O extrato, partições e os dois compostos majoritários isolados, verbascosídeo e ácido betulínico foram capazes de aumentar a sobrevivência e diminuir a peroxidação lipídica de S. cerevisiae contra EROS. Verbascosídeo apresentou atividade antimicrobiana moderada contra Streptococcus pyogenes, S.epidermidis e Staphylococcus aureus. O extrato etanólico e as partições testadas não apresentaram fototoxicidade, indicando que S. cayennensis é uma planta segura para o tratamento de lesões de pele e como possível ingrediente em cosméticos.Unitermos: Stachytarpheta cayennensis, antioxidante, antimicrobial, fototoxicidade, arilpropanoide glicosilado, ácido betulínico.ABSTRACT: Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, plant extract, is a Brazilian medicinal plant externally used in folk medicine for purulent ulcers, skin lesions and internally for inflammations, fever, renal disorders and atherosclerosis. S. cayennesis was studied to identify potential bioactive compounds that may justify their therapeutic use against skin lesions and atherosclerosis. The antioxidant, antimicrobial and phototoxicity capacities of the crude ethanolic extract, fractions and isolated compounds from roots of S. cayennesis were evaluated through in vivo and in vitro tests. Strains of Saccharomyces cerevisiae, an eukaryotic cell model, were used to assess both the phototoxicity and the capacity to protect against the lethal oxidative stress caused by menadione and hydrogen peroxide. The extract, fractions and the two major isolated compounds, verbascoside and betulinic acid, of S. cayennensis were able to increase the tolerance and decrease the lipid peroxidation of S. cerevisiae to reactive oxygen species (ROS). The antioxidant activity was also evaluated by scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH•). Verbascoside exhibited a moderate antimicrobial activity against Streptococcus pyogenes, S.epidermidis and Staphylococcus aureus. Neither the ethanol...

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“…Vahl, Verbenaceae, is a Brazilian medicinal plant, commonly known as "gervao-roxo", "verbena" and "gerbao". The roots of this plant are used in Brazilian folk medicine for purulent ulcers and to treat sore skin wounds by topical application (De Souza., 2004;Penido et al, 2006;Schapoval et al, 1998). The most frequent ethnomedical usages of roots and leaves of S. cayennensis are as inflammations, ulcers, fever and diuretics (Penido et al, 2006;Schapoval et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…The roots of this plant are used in Brazilian folk medicine for purulent ulcers and to treat sore skin wounds by topical application (De Souza., 2004;Penido et al, 2006;Schapoval et al, 1998). The most frequent ethnomedical usages of roots and leaves of S. cayennensis are as inflammations, ulcers, fever and diuretics (Penido et al, 2006;Schapoval et al, 1998). The anti-inflammatory activity of S. cayennensis has been demonstrated in rats by and Penido et al (2006).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant activity of natural compounds of Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, by scavenger of mitochondrial reactive oxygen species

Souza¹,

Rodrigues²,

Santiago³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The etiology of a range of diseases is associated with an excessive generation of reactive oxygen species (ROS). Exacerbated ROS production leads to mitochondrial dysfunction, cellular damage and apoptosis. Nowadays, many strategies are being developed for the targeted delivery of antioxidants compounds to mitochondria, trying to minimize the damages. Production of ROS was investigated by the molecular probes CM-H 2 DCFDA and Amplex Red. The purpose of this work is to evaluate the antioxidant capacity of verbascoside, martinoside, betulinic acid from the Stachytarpheta cayennensis and quercetin by an in vitro assay with isolated mitochondria from mice's brain The results showed that all compounds tested exhibited a scavenger effect on the ROS generated by the isolated mitochondria, which displayed a dependent dose increase.

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Anti-inflammatory and anti-ulcerogenic properties of Stachytarpheta cayennensis (L.C. Rich) Vahl

Cited by 47 publications

References 26 publications

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Evaluation of antimicrobial, antioxidant and phototoxic activities of extracts and isolated compounds from Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae

Antioxidant activity of natural compounds of Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, by scavenger of mitochondrial reactive oxygen species

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