Anti-inflammatory and antibacterial activity study of some novel quinazolinones

Nanthakumar, R.; Muthumani, P.; Girija, K.

doi:10.1016/j.arabjc.2010.12.035

Cited by 14 publications

(8 citation statements)

References 9 publications

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“…Our attempt was to investigate the potential of deep eutectic solvents in the synthesis of quinazolinone derivatives from anthranilic acid and different amines, using two different synthetic approaches. The first approach was intended to use anthranilic acid, amines and trimethyl orthoformate to form 3-substituted-quinazolin-4(3H )-ones (1-4), and the second was the reaction of anthranilic acid, acetic anhydride (AAA) and amine to form 3-substituted-2methyl-quinazolin-4(3H )-ones (5)(6)(7)(8)(9)(10). All our efforts to use DESs in synthesis of compounds 1-4 were not successful, therefore we applied a different method.…”

Section: Resultsmentioning

confidence: 99%

“…Quinazolinones are a group of heterocyclic compounds exhibiting a range of significant biological and pharmacological activities. Their structural diversity greatly affects their biological activity and they are proven to possess antitubercular (1,2), antibacterial (3,4), antitumor (5,6), anticonvulsant (7,8), anti-inflammatory (9,10) and antiviral (11) activities (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Green chemistry approach to the synthesis of 3-substituted-quinazolin-4(3H)-ones and 2-methyl-3-substituted-quinazolin-4(3H)-ones and biological evaluation

Komar

Molnar

Jukić

et al. 2020

Green Chemistry Letters and Reviews

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green chemistry approach to the synthesis of 3-substituted-quinazolin-4(3H)-ones and 2-methyl-3-substituted-quinazolin-4(3H)-ones and biological evaluation

Komar

Molnar

Jukić

et al. 2020

Green Chemistry Letters and Reviews

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“…10 Various researchers have reported the antibacterial activity of quinazolinone derivatives. [11][12][13][14] Subramaniam et al 15…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, antitubercular and antibacterial activity, and molecular docking of 2,3-disubstituted quinazolinone derivatives

Rajasekhar¹,

Nd²,

Surur³

et al. 2016

RRMC

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Quinazolinone derivatives, which are known for their versatile biological activities, have been reported to show significant antibacterial and antitubercular activities. Fourteen compounds that belong to either 2-methyl substituted quinazolinone or 2-phenyl substituted quinazolinones were synthesized. Compounds 5a-e and 8a-c showed a minimum inhibitory concentration value between 6.25 and 100 µg/mL against Mycobacterium tuberculosis. Compounds 5g and 8d, on the other hand, showed significant antibacterial activity against Staphylococcus albus and Strepto coccus pyogenes. The use of amido, thioamido, imidamido, N,N-dimethyl guanidinyl, or N-pyridoyl substituents at 3-position of quinazolinone was found to increase antitubercular activity. A binding affinity prediction by autodock vina was higher for the 2-phenyl series, which may be due to increased hydrophobic interactions within the binding site of enoyl-acyl carrier protein reductase.

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“…Sulfonamides are known to represent a class of medicinally important compounds because of their significant biological properties and their role as pharmacophores . Recently, researchers have shown that sulfonamides can be used as antibacterial agents , anticancer , anti‐inflammatory, analgesic agents , antifungal , and antiviral agents . Before the discovery of antibiotics in the 1940s, sulfonamides were the first efficient compounds used to treat microbial infections .…”

Section: Introductionmentioning

confidence: 99%

4‐Toluenesulfonamide as a Building Block for Synthesis of Novel Triazepines, Pyrimidines, and Azoles

Khodairy

Ali

El‐Wassimy

2015

Journal of Heterocyclic Chem

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N‐{(E)‐(dimethylamino)methylidenearbamothioyl}‐4‐toluenesulfonamide (2) was obtained by reaction of N‐carbamothioyl‐4‐toluenesulfonamide (1) with dimethylformamide dimethylacetal or alternatively by the reaction of 1‐(dimethylamino)methylidenethiourea with tosyl chloride. Compound 2 was reacted with substituted anilines to yield anilinomethylidine derivatives 3a, 3b, 3c, 3d, 3e, 3f, 3g. Treatment of 3a, 3b, 3c, 3d, 3e, 3f, 3g with phenacyl bromide gave triazepines 4a, 4b, 4c, 4d, 4e, 4f, 4g and imidazoles 5a, 5b, 5c, 5d, 5e, 5f, 5g. Esterification of compound 3e afforded ester derivative 6, which was subjected to react with hydrazine to yield hydrazide derivative 7. Oxadiazole 8 was obtained by reaction of 7 with CS2/KOH. Compound 3e was treated with o‐aminophenol or o‐aminothiophenol to give benzazoles 9a, 9b. N‐(Diaminomethylidene)‐4‐toluenesulfonamide (10) reacted with enaminones to yield pyrimidines 11, 12, 13, respectively. The structures of the compounds were elucidated by elemental and spectral analyses. Some selected compounds were screened for their in vitro antifungal activity. In general, the newly synthesized compounds showed good antifungal activity.

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Anti-inflammatory and antibacterial activity study of some novel quinazolinones

Cited by 14 publications

References 9 publications

Green chemistry approach to the synthesis of 3-substituted-quinazolin-4(3H)-ones and 2-methyl-3-substituted-quinazolin-4(3H)-ones and biological evaluation

Green chemistry approach to the synthesis of 3-substituted-quinazolin-4(3H)-ones and 2-methyl-3-substituted-quinazolin-4(3H)-ones and biological evaluation

Synthesis, characterization, antitubercular and antibacterial activity, and molecular docking of 2,3-disubstituted quinazolinone derivatives

4‐Toluenesulfonamide as a Building Block for Synthesis of Novel Triazepines, Pyrimidines, and Azoles

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