Anti‐Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from <i>Salvia lachnostachys</i> Leaves in Mice

Piccinelli, Ana Claudia; Aquino, Diana Figueiredo de Santana; Morato, Priscila Neder; Kuraoka-Oliveira, Ângela Midori; Strapasson, Regiane Lauriano Batista; Santos, Élide Pereira dos; Stefanello, Maria Élida Alves; Oliveira, Rodrigo Juliano; Kassuya, Cândida Aparecida Leite

doi:10.1155/2014/835914

Cited by 20 publications

(18 citation statements)

References 30 publications

(27 reference statements)

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“…Carrageenan-induced paw edema is a commonly used model for acute inflammation study [ 20 , 21 ]. The acute inflammatory response induced by carrageenan injection involves two phases [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models

Zhang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.

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Section: Discussionmentioning

confidence: 99%

Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models

Zhang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…Several reports have indicated a potent antimicrobial activity of essential oils against various microorganisms [3,4]. The antimicrobial potential of these oils has been attributed to the secondary metabolites [5,6]. Vitex agnus-castus L. (VAC) (Verbenaceae) is a deciduous shrub that is native to Mediterranean region, Europe, and Central Asia [7].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Essential Oils From Vitex Agnus-Castus L. Growing in Morocco and Its in Vitro Antibacterial Activity Against Clinical Bacteria Responsible for Nosocomial Infections

Kamari

Taroq

Atki

et al. 2018

Asian J Pharm Clin Res

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Objective: The aim of the current study is to determine the chemical composition and evaluate antibacterial activity of Vitex agnus-castus L. (VAC) essential oils against some bacteria causing nosocomial infections in the neonatal and intensive care rooms at the university hospital center of Fez Morocco. Methods: The phytochemical screening of essential oils was determined using gas chromatography (GC) and GC-mass spectrometry analysis. The antibacterial test was evaluated against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria species (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Proteus mirabilis) using disc diffusion method. Results: Twenty-nine components were identified in the fruits’ oil representing 93.1% of total oil. The major components in the fruits oil are 1,8-cineole (11.6%), α-thujene (9.3%), phyllocladene (8.2%), α-pinene (7.9%), caryophyllene (5.9%), and cubenol (5%). Furthermore, 28 components were identified in the leaf essential oil. The main component was caryophyllene (9.5%), followed by 1,8-cineole (8.7%), manoyl oxide (7.3%), eugenyl acetate (7.1%), phyllocladene (6.8%), and α-pinene (5.2%). Antibacterial activity of both oils showed a strong activity against nosocomial bacteria tested. Conclusion: Essential oils of Moroccan VAC could be exploited as natural drugs for bacteria, especially those who have acquired resistance to conventional antibiotics.

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“…for the ketamine group (1 mg/kg, positive control). The dose of SLEE was determined based on a previous study by our group [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…elegans have been reported [ 2 – 5 ]. Studies have demonstrated anti-inflammatory and antinociceptive effects in different Salvia species [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…SLEE and fruticuline A exhibited anti-inflammatory (paw edema and pleurisy induced by carrageenan injection) and antihyperalgesic inflammatory effects. Fruticuline A dose tested was evaluated in the yield in SLEE (3%) and with this dose relationship, the compound also prevented mechanical hyperalgesia, inhibiting tumor necrosis factor (TNF) [ 6 ]. These results prompted us to investigate the effects of SLEE in other types of pain, such as neuropathic pain-induced hyperalgesia (not only inflammatory pain), as well as related problems, such as depression.…”

Section: Introductionmentioning

confidence: 99%

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Antidepressive and antinociceptive effects of ethanolic extract and fruticuline A from Salvia lachnostachys Benth leaves on rodents

et al. 2017

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ObjectivesThis study investigated the antidepressant and antinociceptive effects of ethanolic extract (SLEE) and pure fruticuline A obtained from Salvia lachnostachys leaves on rats and mice.MethodsIn this study, SLEE (100 mg/kg, p.o. route) was evaluated for its effects on spared nerve injury (SNI) in rats. The animals were submitted to mechanical sensitivity, forced swim (FST) and cold sensitivity tests 10 and 15 days after surgery. SLEE (100 mg/kg, p.o.) and fruticuline A (3 mg/kg, p.o.) were also evaluated with respect to nociceptive behavior induced by formalin. In addition, clonidine-induced depressive-like behavior was also analyzed.ResultsThe oral administration of SLEE for up to 15 days and the subcutaneous injection of 10 mg/kg of ketamine (positive control) significantly inhibited SNI-induced mechanical hyperalgesia and decreased immobility in the FST. On the 15th day of oral treatment, SLEE prevented the SNI-induced increase in cold sensitivity. In the formalin test, SLEE and fruticuline A significantly reduced the frequency of paw licking during the first and second phases and decreased the formation of edema. In locomotor analysis (open field test without clonidine treatment), SLEE and fruticuline A did not alter the response. SLEE and fruticuline A significantly attenuated clonidine-induced suppression of spontaneous locomotor activity (squares invaded and licking) and emotionality (grooming and freezing) compared with controls, similar to the naive group.ConclusionSLEE exhibits antihyperalgesic, antidepressant, and antinociceptive effects, and fruticuline A appears to be at least partly responsible for the effects of SLEE. Together, these results demonstrate the antidepressive effects of SLEE and fruticuline A and indicate that both derivatives obtained from S. lachnostachys act against spontaneous neuropathic pain.

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Anti‐Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice

Cited by 20 publications

References 30 publications

Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models

Oral Administration of Escin Inhibits Acute Inflammation and Reduces Intestinal Mucosal Injury in Animal Models

Chemical Composition of Essential Oils From Vitex Agnus-Castus L. Growing in Morocco and Its in Vitro Antibacterial Activity Against Clinical Bacteria Responsible for Nosocomial Infections

Antidepressive and antinociceptive effects of ethanolic extract and fruticuline A from Salvia lachnostachys Benth leaves on rodents

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