Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Porto, Cínthia R.C.; Soares, Luiz Alberto Lira; Souza, Tatiane Pereira de; Petrovick, Pedro Ros; Lyra, Ibson L.; Júnior, Raimundo F. Araújo; Langassner, Silvana Maria Zucolotto; Ferreira, Aurigena A. A.; Guerra, Gerlane Coelho Bernardo

doi:10.1590/s0102-695x2013005000004

Cited by 16 publications

(8 citation statements)

References 30 publications

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“…However, other rat studies suggest that the hydroalcoholic and spray‐dried standardized extracts may exert both significant peripheral and central analgesia. Hence, there remains a need for the further study of the effect of P. niruri extracts on major pain pathways to clarify the ambiguity that surrounds its analgesic mechanism.…”

Section: Anti‐inflammatory Antinociceptive and Analgesic Activitymentioning

confidence: 99%

The pharmacological potential of Phyllanthus niruri

Lee

Khoo

Adnan

et al. 2016

Journal of Pharmacy and Pharmacology

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Introduction Phyllanthus niruri is a traditional shrub of the genus Phyllanthaceae with long-standing Ayurvedic, Chinese and Malay ethnomedical records. Preliminary studies from cell and animal model have provided valuable scientific evidence for its use. Aim This review aims to summarize selected scientific evidence on the pharmacological properties of P. niruri over the past 35 years while identifying potential areas of further development of this herb as an economical adjunct. Methods The review covers literature pertaining to the evidence base therapeutic potential of P. niruri spanning from 1980 to 2015 available on PubMed.Results Evidence suggests that the extracts of P. niruri possess hepatoprotective, antiviral, antibacterial, hypolipidaemic, hypoglycaemic, analgesic, anti-inflammatory, cardioprotective, anti-urolithiatic and antihyperuricaemic properties due its novel bioactive compounds. Conclusion Scientific evidence suggests that there is strong pharmacological potential in developing P. niruri as a drug to be used in liver disorders and in antiviral therapy. Despites this, large-scale heterogeneity in study protocol and unstandardized reporting standards limit the ability for valuable comparison and may mask the ability to replicate these studies. Thus interpretation of findings should be performed with caution and further studies should be performed in line with best practices. More cheminformatics, toxicological and mechanistic studies would aid the progress to clinical trial studies.

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Section: Anti‐inflammatory Antinociceptive and Analgesic Activitymentioning

confidence: 99%

The pharmacological potential of Phyllanthus niruri

Lee

Khoo

Adnan

et al. 2016

Journal of Pharmacy and Pharmacology

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“…Research by Porto at al., 2013, showed that Phyllanthus niruri spray-dried standardized extract has anti-inflammatory effect on mus musculus Swiss male mice (18-30 g) induced by carrageenan (1% w/v, 50 μL). 10 Methanol extract of Phyllanthus niruri decreased edema in Swiss albino rats induced by carrageenan. This extract showed a reduction of 46.80%; 55.32% and 69.14% at doses of 100; 200 and 400 mg/kg respectively.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Effect of Phyllanthus niruri L. from Indonesia (Pre-clinical Study)

Sutrisna¹,

Maryati²,

Wahyuni³

et al. 2019

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At the present, the treatment of inflammation using NSAIDs (non-steroidal anti-inflammatory drugs). Research by Teslim et al, that published in 2014, found there are many side effect of this drugs, among others: high blood pressure, low blood pressure, indigestion, gastro-intestinal bleeding, ulcer, vomiting, diarrhea, abdominal pain, heart attack, kidney disorders, dizziness, comma/ unconsciousness, nausea, constipation, gastric pain and liver problems. 7 Due to many side effects of NSAIDs, many people used medicinal traditional plant to treat pain and inflammation. Currently, there is no study which is reporting on anti-inflammatory effect of effect ethyl acetate fraction of ethanol extract P. niruri L.

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“…In addition, administration of the P. niruri extract to mice has successfully regulated serum levels of primary and secondary antibodies (Eze, 2014). Another study conducted by Porto et al (2013) revealed that spray-dried standardized extracts of P. niruri have potentially inhibited carrageen-induced edema and thioglycolate-induced neutrophil migration in Mus musculus Swiss male mice. Another study evaluated the effects of the plant extract on leukocyte profile of broiler chickens infected with Mycoplasma gallisepticum .…”

Section: Immunomodulatory Effects Of Phyllanthus Species and Their Bimentioning

confidence: 99%

An Insight Into the Modulatory Effects and Mechanisms of Action of Phyllanthus Species and Their Bioactive Metabolites on the Immune System

et al. 2019

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Phyllanthus species (family; Euphorbiaceae ) have been intensively studied for their immunomodulating effects due to their wide-ranging uses to treat immune-related diseases in indigenous medicine, which are primarily lack of scientific basis. The focuses of this review are on the significance of Phyllanthus species and their bioactive metabolites particularly corilagin ( 1 ), geraniin ( 2 ), gallic acid ( 3 ), phyllanthin ( 4 ), hypophyllanthin ( 5 ), ellagic acid ( 6 ), phyltetralin ( 7 ), niranthin ( 8 ), catechin ( 9 ), quercetin ( 10 ), astragalin ( 11 ), and chebulagic acid ( 12 ) in the modulation of both innate and adaptive immune systems through various mechanisms and their possible therapeutic benefits for treatment of immune-related diseases. We have compiled all significant findings published in the literature, and the data were analyzed critically to provide perspectives and directions for future research for the plants as a prospective source of novel immunomodulating agents. Various Phyllanthus species particularly Phyllanthus amarus , Phyllanthus emblica , Phyllanthus niruri , and Phyllanthus urinaria have been documented to possess significant immunomodulatory effects. However, the possible challenges encountered by the application of extracts of various Phyllanthus species and their bioactive constituents as immunomodulators need to be addressed. Most reports on the biological and pharmacological studies of the plants were based on crude extracts. The extracts were not chemically characterized, and the contributions of their chemical constituents to the bioactivities were not identified. The underlying mechanisms involved in the immunomodulatory effects of the Phyllanthus species were not indepthly studied due to limitations in terms of design, conduct, and interpretation. Extensive experimental and preclinical studies on the immunomodulating potential of Phyllanthus species should be carried out to provide sufficient data to prove that their traditional uses are inherently effective and safe and will allow clinical trials to be pursued for their further development as therapeutic agents to treat immune-related disorders.

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Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Cited by 16 publications

References 30 publications

The pharmacological potential of Phyllanthus niruri

The pharmacological potential of Phyllanthus niruri

Anti-inflammatory Effect of Phyllanthus niruri L. from Indonesia (Pre-clinical Study)

An Insight Into the Modulatory Effects and Mechanisms of Action of Phyllanthus Species and Their Bioactive Metabolites on the Immune System

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